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JNJ-7925476
JNJ-7925476 is a triple reuptake inhibitor antidepressant discovered by Johnson & Johnson, but never marketed. These molecules were first prepared by Bruce E. Maryanoff and coworkers during the late 1970s–1980s. The structure is a pyrroloisoquinoline core, with an overlaid benzhydryl motif. Incorporating the pyrrolidine, pyrrolidino ring onto the tetrahydroisoquinoline scaffolding markedly improves potency, although this only works for one of the available stereoisomers. JNJ-7925476 is a racemic preparation of the more potent diastereomer. Of these enantiomers, the eutomer is the (6''R'',10b''S'') stereoisomer, known as JNJ-39836966, and the distomer, (6''S'',10b''R''), is JNJ-39836732 There is some confusion over the nomenclature and Cis–trans isomerism, ''cis''/''trans'' isomeric relationship at the piperidine ring. The compounds as depicted have the carbon of the pyrrolidine carbon and the phenyl ''cis'', but Maryanoff and coworkers are of the opinion that the compound ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzhydryl
The benzhydryl compounds are a group of organic compounds whose parent structure, parent structural formula, structures include diphenylmethane (which is two benzene rings connected by a single substituent#Methane substituents, methane), with any number of attached substituents, including bridge (chemical), bridges. This group typically excludes compounds in which either benzene is fused to another ring (bicyclic molecule, bicyclic, tricyclic, polycyclic compound, polycyclic) or includes a heteroatom, or where the methane connects to triphenylmethane, three or tetraphenylmethane, four benzenes. The benzhydryl ''radical (chemistry), radical'' can be abbreviated or Bzh. Carboaromatic Alcohols *''Acyclic:'' pridinol *''Pyrolidino:'' diphenylprolinol *''2-Piperidine:'' pipradrol *''4-Piperidine:'' terfenadine, fexofenadine *''Benzilic ester:'' 3-Quinuclidinyl benzilate, QNB, N-Methyl-3-piperidyl benzilate, JB-336, N-ethyl-3-piperidyl benzilate, JB-318, benactyzine Alkenes *''Tricyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triple Reuptake Inhibitor
Triple is used in several contexts to mean "threefold" or a " treble": Sports * Triple (baseball), a three-base hit * A basketball three-point field goal * A figure skating jump with three rotations * In bowling terms, three strikes in a row * In cycling, a crankset with three chainrings Places * Triple Islands, an uninhabited island group in Nunavut, Canada * Triple Island, British Columbia, Canada * Triple Falls (other), four waterfalls in the United States & Canada * Triple Glaciers, in Grand Teton National Park, Wyoming * Triple Crossing, Richmond, Virginia, believed to be the only place in North America where three Class I railroads cross * Triple Bridge, a stone arch bridge in Ljubljana, Slovenia Transportation * Kawasaki triple, a Japanese motorcycle produced between 1969 and 1980 * Triumph Triple, a motorcycle engine from Triumph Motorcycles Ltd * A straight-three engine * A semi-truck with three trailers Science and technology * Triple (mathematics) (3- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amfonelic Acid
Amfonelic acid (AFA; WIN 25,978) is a research chemical and dopaminergic stimulant with antibiotic properties. Limited clinical trials have been conducted, and it is primarily used in scientific research. History The stimulant properties of AFA were discovered incidentally at Sterling-Winthrop during research on the antibiotic nalidixic acid. In addition to behaving as an antibiotic, it was found that many derivatives of nalidixic acid have either stimulant or depressant effects on the central nervous system. Researchers at Sterling-Winthrop found that AFA had a higher potency and therapeutic index than cocaine or amphetamine, leading to further study of the drug. A small number of clinical trials were held in the 1970s, but clinical evaluation of AFA was discontinued after it was found that AFA exacerbated psychotic symptoms in schizophrenic patients and produced undesirable stimulant properties in geriatric depressives. AFA remains a widely used pharmacological tool for study o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethynyl Compounds
In organic chemistry, an ethynyl group is a functional group with the formula −C≡CH, representing an acetylene molecule with one fewer hydrogen atom. * Ethynyl group (HC≡C–), also designated as an acetylenic group (from acetylene), is referred to in IUPAC chemical nomenclature with the -yne suffix. It is sometimes designated as ''ethinyl'' in compounds such as ethinylestradiol and ethisterone (ethinyltestosterone). See main page alkynes. See also * Ethynylation * Ethynyl radical * Propynyl (H3C–C≡C–R, 1-propynyl group; or HC≡C–CH2–R, 2-propynyl group, Propargyl In organic chemistry, the propargyl group is a functional group of 2- propynyl with the structure . It is an alkyl group derived from propyne (). The term propargylic refers to a saturated position ( ''sp''3-hybridized) on a molecular framework ...) Alkynyl groups {{hydrocarbon-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amide
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a chemical compound, compound with the general formula , where R, R', and R″ represent any group, typically organyl functional group, groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the Polymer backbone, main chain of a protein, and an isopeptide bond when it occurs in a side chain, as in asparagine and glutamine. It can be viewed as a Derivative (chemistry), derivative of a carboxylic acid () with the hydroxyl group () replaced by an amino group (); or, equivalently, an acyl group, acyl (alkanoyl) group () joined to an amino group. Common amides are formamide (), acetamide (), benzamide (), and dimethylformamide (). Some uncommon examples of amides are ''N''-chloroacetamide () and chloroformamide (). Amides are qualified as primary (chemistry), primary, secondary (chemistry), secondary, and tertiary (chemistry), tertiary according to the number of acyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Styrene Oxide
Styrene is an organic compound with the chemical formula C6H5CH=CH2. Its structure consists of a vinyl group as substituent on benzene. Styrene is a colorless, oily liquid, although aged samples can appear yellowish. The compound evaporates easily and has a sweet smell, although high concentrations have a less pleasant odor. Styrene is the precursor to polystyrene and several copolymers, and is typically made from benzene for this purpose. Approximately 25 million tonnes of styrene were produced in 2010, increasing to around 35 million tonnes by 2018. Natural occurrence Styrene is named after storax balsam (often commercially sold as ''styrax''), the resin of Liquidambar trees of the Altingiaceae plant family. Styrene occurs naturally in small quantities in some plants and foods (cinnamon, coffee beans, balsam trees and peanuts) and is also found in coal tar. History In 1839, the German apothecary Eduard Simon isolated a volatile liquid from the resin (called ''storax ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mandelic Acid
Mandelic acid is an aromatic alpha hydroxy acid with the molecular formula C6H5CH(OH)CO2H. It is a white crystalline solid that is soluble in water and polar organic solvents. It is a useful precursor to various drugs. The molecule is chiral. The racemic mixture is known as ''paramandelic acid''. Isolation, synthesis, occurrence Mandelic acid was discovered in 1831 by the German pharmacist Ferdinand Ludwig Winckler (1801–1868) while heating amygdalin, an extract of bitter almonds, with diluted hydrochloric acid. The name is derived from the German "Mandel" for "almond". Mandelic acid is usually prepared by the acid-catalysed hydrolysis of mandelonitrile, which is the cyanohydrin of benzaldehyde. Mandelonitrile can also be prepared by reacting benzaldehyde with sodium bisulfite to give the corresponding adduct, forming mandelonitrile with sodium cyanide, which is then hydrolyzed: : Alternatively, it can be prepared by base hydrolysis of phenylchloroacetic acid as well as dibrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Impotent
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity. It is the most common sexual problem in males and can cause psychological distress due to its impact on self-image and sexual relationships. The majority of ED cases are attributed to physical risk factors and predictive factors. These factors can be categorized as vascular, neurological, local penile, hormonal, and drug-induced. Notable predictors of ED include aging, cardiovascular disease, diabetes mellitus, high blood pressure, obesity, abnormal lipid levels in the blood, hypogonadism, smoking, depression, and medication use. Approximately 10% of cases are linked to psychosocial factors, encompassing conditions such as depression, stress, and problems within relationships. The term ''erectile dysfunction ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Piperidine
Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor described as objectionable, typical of amines. The name comes from the genus name '' Piper'', which is the Latin word for pepper. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Production Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: : C5H5N + 3 H2 → C5H10NH Pyridine can also be reduce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Citalopram
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and social phobia. The antidepressant effects may take one to four weeks to occur. It is typically taken oral administration, orally (swallowed by mouth). In some Europe, European countries, it is sometimes given intravenous, intravenously (injected into a vein) to initiate treatment, before switching to the oral route of administration for continuation of treatment. It has also been used intravenously in other parts of the world in some other circumstances. Common side effects include nausea, trouble sleeping, sexual problems, shakiness, feeling tired, and sweating. Serious side effects include an increased risk of suicide in those under the age of 25, serotonin syndrome, glaucoma, and QT prolongation. It should not be used in persons who take o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
