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J. F. A. McManus
Joseph Forde Anthony McManus, (July 13, 1911 – March 4, 1980) was a Canadian pathologist who is best known for his formulation of one of the most frequently used stains in histopathology; the McManus Periodic acid-Schiff stain. Joe McManus was a pioneer in the field of Histochemistry during its period of expanding growth and application in the 1940s and 1950s. He was, furthermore, an exceptionally observant microscopist. The term he coined "Juxtaglomerular Complex" was used to denote the relationship of the renal tubular macula densa to the arteriolar granular cells. It was derived from his observations that the golgi of the distal tubular cells were reversed to a position beneath the nuclei in the macula densa and that the basement membrane between the macula densa and arteriolar cells was absent. His publications on glomerular obsolescence and late in his career on the dialysis kidney were based upon the same meticulous study of renal morphology. Education Dr. J.F.A. McM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathologist
Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area that includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"). The suffix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomyopathy) and psychological conditions (such as ps ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical University Of South Carolina
The Medical University of South Carolina (MUSC) is a public medical school in Charleston, South Carolina. It opened in 1824 as a small private college aimed at training physicians and has since established hospitals and medical facilities across the state. It is one of the oldest continually operating schools of medicine in the United States and the oldest in the Deep South. The school has expanded into a state university with a medical center and six colleges for the education of health professionals, biomedical scientists, and other health care personnel. It also operates as a center for research and has a public hospital. Colleges College of Medicine History The College of Medicine began in 1823 with the incorporation of the Medical College of South Carolina, a private institution of the Medical Society of South Carolina. Seven Charleston physicians formed the initial faculty with 30 students enrolled in 1824. The first graduation was on April 4, 1825. With the excepti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Northumberland County, New Brunswick
The term "the people" refers to the public or common mass of people of a polity. As such it is a concept of human rights law, international law as well as constitutional law, particularly used for claims of popular sovereignty Popular sovereignty is the principle that the leaders of a state and its government A government is the system or group of people governing an organized community, generally a State (polity), state. In the case of its broad associativ .... In contrast, a people is any plurality of Person, persons considered as a whole. Used in politics and law, the term "a people" refers to the collective or community of an ethnic group or nation. Concepts Legal Chapter One, Article One of the Charter of the United Nations states that "peoples" have the right to self-determination. Though the mere status as peoples and the right to self-determination, as for example in the case of Declaration on the Rights of Indigenous Peoples, Indigenous peoples (''p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1980 Deaths
Events January * January 4 – U.S. President Jimmy Carter proclaims a grain embargo against the USSR with the support of the European Commission. * January 6 – Global Positioning System time epoch begins at 00:00 UTC. * January 9 – In Saudi Arabia, 63 Islamist insurgents are beheaded for their part in the siege of the Great Mosque in Mecca in November 1979. * January 14 – Congress (I) party leader, Indira Gandhi returns to power as the Prime Minister of India. * January 20 – At least 200 people are killed when the Corralejas Bullring collapses at Sincelejo, Colombia. * January 21 – The London Gold Fixing hits its highest price ever of $843 per troy ounce ($2,249.50 in 2020 when adjusted for inflation). * January 22 – Andrei Sakharov, Soviet scientist and human rights activist, is arrested in Moscow. * January 26 – Israel and Egypt establish diplomatic relations. * January 27 – Canadian Caper: Six United States diplomats, posing as Canadians, mana ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1911 Births
Events January * January 1 – A decade after federation, the Northern Territory and the Australian Capital Territory are added to the Commonwealth of Australia. * January 3 ** 1911 Kebin earthquake: An earthquake of 7.7 Moment magnitude scale, moment magnitude strikes near Almaty in Russian Turkestan, killing 450 or more people. ** Siege of Sidney Street in London: Two Latvian people, Latvian anarchists die, after a seven-hour siege against a combined police and military force. Home Secretary Winston Churchill arrives to oversee events. * January 4 – Comparison of the Amundsen and Scott expeditions, Amundsen and Scott expeditions: Robert Falcon Scott's British Terra Nova Expedition, ''Terra Nova'' Expedition to the South Pole arrives in the Antarctic and establishes a base camp at Cape Evans on Ross Island. * January 5 – Egypt's Zamalek SC is founded as a general sports and Association football club by Belgian lawyer George Merzbach as Q ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sialidase
Exo-α-sialidase (, sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycoside hydrolase that cleaves the glycosidic linkages of neuraminic acids: : Hydrolysis of α-(2→3)-, α-(2→6)-, α-(2→8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. Viral neuraminidase was the first neuraminidase to be identified. It was discovered in 1957 by Alfred Gottschalk at the Walter and Eliza Hall Institute in Melbourne. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologues are found in mammalian cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyaluronidase
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct groups, a scheme based on the enzyme reaction products. The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase. In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). The genes for HYAL1-3 are clustered in chromosome 3, while HYAL4-6 are clustered in chromosome 7. HYAL1 and HYAL2 are the major hyaluronidases in most tissues. GPI-anchored HYAL2 is responsible for cleaving high-molecular weight hyaluronic acid, which is mostly bound to the CD44 receptor. The resulting hyaluronic acid fragments of variable size are then further hydrolyzed by HYAL1 after being internalized into endo-lysosomes; this generates hyaluronic acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diastase
A diastase (; from Greek διάστασις, "separation") is any one of a group of enzymes that catalyses the breakdown of starch into maltose. For example, the diastase α-amylase degrades starch to a mixture of the disaccharide maltose; the trisaccharide maltotriose, which contains three α (1-4)-linked glucose residues; and oligosaccharides, known as dextrins, that contain the α (1-6)-linked glucose branches. Diastase was the first enzyme discovered. It was extracted from malt solution in 1833 by Anselme Payen and Jean-François Persoz, chemists at a French sugar factory. The name "diastase" comes from the Greek word διάστασις (''diastasis'') (a parting, a separation), because when beer mash is heated, the enzyme causes the starch in the barley seed to transform quickly into soluble sugars and hence the husk to separate from the rest of the seed. Today, "diastase" refers to any α-, β-, or γ-amylase (all of which are hydrolases) that can break down carbohydra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraffin Wax
Paraffin wax (or petroleum wax) is a soft colorless solid derived from petroleum, coal, or oil shale that consists of a mixture of hydrocarbon molecules containing between 20 and 40 carbon atoms. It is solid at room temperature and melting point, begins to melt above approximately , and its boiling point is above . Common applications for paraffin wax include lubrication, electrical insulation, and candles; dyed paraffin wax can be made into crayons. Un-dyed, unscented paraffin candles are odorless and bluish-white. Paraffin wax was first created by Carl Reichenbach#Scientific contributions, Carl Reichenbach in Germany in 1830 and marked a major advancement in candlemaking technology, as it burned more cleanly and reliably than tallow candles and was cheaper to produce. In chemistry, ''paraffin'' is used synonymously with ''alkane'', indicating hydrocarbons with the general formula C''n''H2''n''+2. The name is derived from Latin ''parum'' ("very little") + ''affinis'', meaning ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuskegee University
Tuskegee University (Tuskegee or TU; formerly known as the Tuskegee Institute) is a private, historically black land-grant university in Tuskegee, Alabama, United States. It was founded as a normal school for teachers on July 4, 1881, by the Alabama Legislature. The campus was designated as the Tuskegee Institute National Historic Site by the National Park Service in 1974. The university has been home to a number of important African American figures, including founder and first principal/president Booker T. Washington, scientist George Washington Carver, and World War II's Tuskegee Airmen. Tuskegee University offers 43 bachelor's degree programs, including a five-year accredited professional degree program in architecture, 17 master's degree programs, and 5 doctoral degree programs, including the Doctor of Veterinary Medicine. Tuskegee is home to nearly 3,000 students from around the U.S. and over 30 countries. Tuskegee's campus was designed by architect Robert Robin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indiana University
Indiana University (IU) is a state university system, system of Public university, public universities in the U.S. state of Indiana. The system has two core campuses, five regional campuses, and two regional centers under the administration of IU Indianapolis. The flagship campus of Indiana University is Indiana University Bloomington. Campuses Core campuses *Indiana University Bloomington (IU Bloomington) is the flagship campus of Indiana University. The Bloomington campus is home to numerous premier Indiana University schools, including the College of Arts and Sciences, the Hutton Honors College, the Jacobs School of Music, an extension of the Indiana University School of Medicine, the Indiana University School of Informatics, Luddy School of Informatics, Computing, and Engineering, which includes the former School of Library and Information Science (now Department of Library and Information Science), School of Optometry, the Indiana University School of Public and Enviro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histopathology
Histopathology (compound of three Greek words: 'tissue', 'suffering', and '' -logia'' 'study of') is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks "). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buffered saline). Preparation for h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
