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Isometamidium Chloride
Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine. It consists of a single ethidium bromide like subunit linked to a fragment of the diminazene molecule. Resistance The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, '' T. congolense'' isolated from Boran cattle Boran cattle are a popular Zebu beef breed in eastern Africa. Through DNA sampling, Hanotte et al. have analyzed the genetic make-up of the Boran and it consists of the following genetic proportions—64% ''Bos indicus'', 24% European ''Bos tau .... References Amidines Antiparasitic agents Quaternary ammonium compounds Triazenes {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triazene
Triazene is an unsaturated inorganic compound having the chemical formula N3 H3. It has one double bond and is the second-simplest member of the azene class of hydronitrogen compounds, after diimide. Triazenes are a class of organic compounds containing the functional group −N(H)−N=N−. Triazene, possibly along with its isomer triimide (HNNHNH), has been synthesized in electron-irradiated ices of ammonia and ammonia/dinitrogen and detected in the gas phase after sublimation. References External links *IUPAC Gold Book The International Union of Pure and Applied Chemistry (IUPAC) publishes many books which contain its complete list of definitions. The definitions are divided initially into seven IUPAC Colour Books: Gold, Green, Blue, Purple, Orange, White, and R ...br>definition {{Hydrides by group Nitrogen hydrides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanocidal Agent
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: * Aminoquinuride * benzonidazole * blasticidin S * DAPI * diminazene * diminazene aceturate * eflornithine * ethidium * isometamidium chloride * lonidamine * melaminylthioarsenate * melarsoprol * nifurtimox * pentamidine * posaconazole * puromycin * quinapyramine * salicylhydroxamic acid * suramin * tetraphenylporphine sulfonate Resistance , 17 or 18 African countries had confirmed resistant parasite populations, and that was up to 21. Multiply resistant populations are an increasing problem in the Adamawa Region of Cameroon and south east Mali. The Gibe River Valley in southwest Ethiopia showed universal resistance (in '' T. congolense'' isolated from Boran cattle) between July 1989 and February 1993. This likely indicates a permanent loss of function in this area for the tested trypanocides, diminazene aceturate, isometamidium chloride, and homidium chloride. See als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethidium Bromide
Ethidium bromide (or homidium bromide, chloride salt homidium chloride) is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. It is commonly abbreviated as EtBr, which is also an abbreviation for bromoethane. To avoid confusion, some laboratories have used the abbreviation EthBr for this salt. When exposed to ultraviolet light, it will fluoresce with an orange colour, intensifying almost 20-fold after binding to DNA. Under the name homidium, it has been commonly used since the 1950s in veterinary medicine to treat trypanosomiasis in cattle. The high incidence of antimicrobial resistance makes this treatment impractical in some areas, where the related isometamidium chloride is used instead. Despite its reputation as a mutagen, tests have shown it to have low mutagenicity without metabolic activation. Structure, chemistry, and fluorescence As with most fluoresc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diminazene
Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against certain protozoa such as ''Babesia'', ''Trypanosoma'', and '' Cytauxzoon''. The drug may also be effective against certain bacteria including ''Brucella'' and ''Streptococcus''. Chemically it is a di-amidine and it is formulated as its aceturate salt, diminazene aceturate. The mechanism is not well understood; it probably inhibits DNA replication, but also has affinity to RNA. Side effects Acute side effects include vomiting, diarrhea, and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; camels are especially susceptible to these effects. Resistance The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, '' T. c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gibe River
The Gibe River (also Great Gibe River) is by far the largest tributary of the Omo River in southwestern Ethiopia and flows generally south-southeast. The confluence of the Gibe River with the smaller Wabe River forms the Omo River. The whole drainage basin is sometimes referred to as the ''Omo-Gibe River Basin'' with the Gibe and the Omo draining the (respectively) upper and lower reaches. In common with most of Ethiopia's rivers, the Gibe is not navigable. Overview The Gibe rises at an elevation of more than 2,000 m north of Bila town, west of the Chomen swamp from Gudeya Bila woreda, which is located in the East Welega Zone, Oromia Region. The river then flows generally to the southeast towards its confluence with the Wabe River. Its tributaries include the Amara, Alanga, and Gilgel Gibe rivers. The southern drainage area of the Gibe includes the Gibe region, site of a number of historic kingdoms of the Oromo and the Sidama people. The Gibe River terminates at an el ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethiopia
Ethiopia, officially the Federal Democratic Republic of Ethiopia, is a landlocked country located in the Horn of Africa region of East Africa. It shares borders with Eritrea to the north, Djibouti to the northeast, Somalia to the east, Kenya to the south, South Sudan to the west, and Sudan to the northwest. Ethiopia covers a land area of . , it has around 128 million inhabitants, making it the List of countries and dependencies by population, thirteenth-most populous country in the world, the List of African countries by population, second-most populous in Africa after Nigeria, and the most populous landlocked country on Earth. The national capital and largest city, Addis Ababa, lies several kilometres west of the East African Rift that splits the country into the African Plate, African and Somali Plate, Somali tectonic plates. Early modern human, Anatomically modern humans emerged from modern-day Ethiopia and set out for the Near East and elsewhere in the Middle Paleolithi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma Congolense
''Trypanosoma congolense'' is a species of trypanosomes and is the major pathogen responsible for the disease nagana in cattle and other animals including sheep, pigs, goats, horses and camels, dogs, as well as laboratory mice. It is the most common cause of nagana in east Africa, but is also a major cause of nagana in west Africa. This parasite is spread by tsetse flies. In its mammalian host, ''Trypanosoma congolense'' only lives in blood vessels, and causes in particular anaemia. , USAHA gray book, 6th ed. (1998). Infection process ''T. congolense'' causes . Nok ''et al.'', 2003 find ''T. congolense'' to alter the surf ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boran Cattle
Boran cattle are a popular Zebu beef breed in eastern Africa. Through DNA sampling, Hanotte et al. have analyzed the genetic make-up of the Boran and it consists of the following genetic proportions—64% ''Bos indicus'', 24% European ''Bos taurus'' and 12% African ''Bos taurus''. History Kenyan Boran cattle were developed from the native shorthorned Zebu cattle of the Borana Oromo people of southern Ethiopia. They are usually white or fawn, with the bulls being darker with black point. Their great similarity to the American Brahman cattle is not without basis, they are also descended from cattle from the western coast of India, only much earlier. Since 1951, the Boran Cattle Breeders' Society has been managed and strategically breeding Boran cattle in Kenya. As of 2008, there were approximately 454 beef ranches in the country, which can be classified based on ownership as one of five categories: group ranches, private company ranches, co-operative ranches, public company ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elsevier
Elsevier ( ) is a Dutch academic publishing company specializing in scientific, technical, and medical content. Its products include journals such as ''The Lancet'', ''Cell (journal), Cell'', the ScienceDirect collection of electronic journals, ''Trends (journals), Trends'', the ''Current Opinion (Elsevier), Current Opinion'' series, the online citation database Scopus, the SciVal tool for measuring research performance, the ClinicalKey search engine for clinicians, and the ClinicalPath evidence-based cancer care service. Elsevier's products and services include digital tools for Data management platform, data management, instruction, research analytics, and assessment. Elsevier is part of the RELX Group, known until 2015 as Reed Elsevier, a publicly traded company. According to RELX reports, in 2022 Elsevier published more than 600,000 articles annually in over 2,800 journals. As of 2018, its archives contained over 17 million documents and 40,000 Ebook, e-books, with over one b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amidines
Amidines are organic compounds with the functional group RC(NR)NR2, where the R groups can be the same or different. They are the imine derivatives of amides (RC(O)NR2). The simplest amidine is formamidine, HC(=NH)NH2. Examples of amidines include: * DBU * diminazene * benzamidine * Pentamidine * Paranyline Preparation A common route to primary amidines is the Pinner reaction. Reaction of the nitrile with alcohol in the presence of acid gives an iminoether. Treatment of the resulting compound with ammonia then completes the conversion to the amidine. Instead of using a Bronsted acid, Lewis acids such as aluminium trichloride promote the direct amination of nitriles, or, in certain exceptional cases, of amides. Dimethylformamide acetal reacts with primary amines to give amidines: :Me2NC(H)(OMe)2 + RNH2 → Me2NC=NHR + 2 MeOH Catalysis is likewise not required for direct amination of an imidoyl chloride. Amidines are also prepared by the addition of organolithi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiparasitic Agents
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases, such as those caused by helminths, amoeba, ectoparasites, parasitic fungi, and protozoa, among others. Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually effective against a limited number of parasites within a particular class. Antiparasitics are one of the antimicrobial drugs which include antibiotics that target bacteria, and antifungals that target fungi. They may be administered orally, intravenously or topically. Overuse or misuse of antiparasitics can lead to the development of antimicrobial resistance. Broad-spectrum antiparasitics, analogous to broad-spectrum antibiotics for bacteria, are antiparasitic drugs with efficacy in treating a wide range of parasitic infections caused by parasites from different classes. Types Broad-spectrum * Nitazoxanide Antiprotozoals * Melarsoprol (for treatment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quaternary Ammonium Compounds
In organic chemistry, quaternary ammonium cations, also known as quats, are positively-charged polyatomic ions of the structure , where R is an alkyl group, an aryl group or organyl group. Unlike the ammonium ion () and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution. Quaternary ammonium salts or quaternary ammonium compounds (called quaternary amines in oilfield parlance) are salts of quaternary ammonium cations. Polyquats are a variety of engineered polymer forms which provide multiple quat molecules within a larger molecule. Quats are used in consumer applications including as antimicrobials (such as detergents and disinfectants), fabric softeners, and hair conditioners. As an antimicrobial, they are able to inactivate enveloped viruses (such as SARS-CoV-2). Quats tend to be gentler on surfaces than bleach-based disinfectants, and are generally fabric-safe. Synthesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
