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Isabelle Dinoire
Isabelle Dinoire (3 February 1967 – 22 April 2016) was a French woman who was the first person to undergo a partial face transplant, after her Labrador retriever cross breed mauled her in May 2005. She underwent a 15-hour operation in November 2005 in which surgeons transplanted the nose, lips and chin from a brain-dead donor at a hospital in Amiens. She died at age 49 in April 2016, though her death was not announced until more than four months later. Personal life Dinoire lived in Valenciennes, northern France, and she was the mother of two children. Mutilation incident Dinoire's dog mauled her face after she passed out from an overdose of sleeping pills.suicide attempt, and that Dinoire wrote about her suicidal feelings in her own memoir. The hospital denied this, saying that she said she had taken a pill to go to sleep after a family argument and was bitten by her Labrador during the night. In a statement made on 6 February 2006, Dinoire said that "after a very upsetting w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maubeuge
Maubeuge (; historical nl, Mabuse or nl, Malbode; pcd, Maubeuche) is a commune in the Nord department in northern France. It is situated on both banks of the Sambre (here canalized), east of Valenciennes and about from the Belgian border. History Maubeuge (ancient ''Malbodium'', from Latin, derived from the Old Frankish name ''Malboden'', meaning "assizes of Boden") owes its origin to Maubeuge Abbey, a double monastery, for men and women, founded in the 7th century by Saint Aldego, the relics of whom are preserved in the church. It subsequently belonged to the territory of Hainaut. The town was part of the Spanish Netherlands and changed hands a number of times before it was finally ceded to France in the 1678 Treaty of Nijmegen. As part of Vauban's ''pré carré'' plan that protected France's northern borders with a double line of fortresses, it was extensively fortified as directed by Louis XIV of France. Besieged in 1793 by Prince Josias of Saxe-Coburg-Saa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain-dead
Brain death is the permanent, irreversible, and complete loss of brain function which may include cessation of involuntary activity necessary to sustain life. It differs from persistent vegetative state, in which the person is alive and some autonomic functions remain. It is also distinct from comas as long as some brain and bodily activity and function remain, and it is also not the same as the condition locked-in syndrome. A differential diagnosis can medically distinguish these differing conditions. Brain death is used as an indicator of legal death in many jurisdictions, but it is defined inconsistently and often confused by the public. Various parts of the brain may keep functioning when others do not anymore, and the term "brain death" has been used to refer to various combinations. For example, although one major medical dictionary considers "brain death" to be synonymous with "cerebral death" (death of the cerebrum), the US National Library of Medicine Medical Subject Hea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Connie Culp
Connie Culp (March 26, 1963 – July 29, 2020) was the first United States recipient of a partial face transplant, performed at the Cleveland Clinic in December 2008. Facial disfigurement Culp was shot in the face by her husband Thomas G. "Tom" Culp in a failed murder–suicide on September 21, 2004 inside their bar in Hopedale, Ohio. He also survived and was convicted in 2005 of aggravated attempted murder with a seven-year prison sentence.Kroenig, Julie (April 13, 2005)Man Shoots Wife in Face...Sentenced to 7 Years. WTRF Culp forgave her husband at the sentencing and said she would be waiting when he gets out of prison,Mazure, Steve (April 14, 2005Gunman Sentenced--Wife Forgives Him. WBOYStaff report (February 25, 2008)Woman Speaks Out After Husband Shoots Her In Face. WTOV but on September 22, 2009, Culp said on an episode of ''Oprah'' that she no longer planned to wait for her former husband after her daughter asked her, "Mom, what kind of example would you be setting for m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunosuppressive Drug
Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent activity of the immune system. Classification Immunosuppressive drugs can be classified into five groups: * glucocorticoids * cytostatics * antibodies * drugs acting on immunophilins * other drugs Glucocorticoids In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. Nevertheless, they do not prevent an infection and also inhibit later reparative processes. Immunosuppressive mechanism Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types of transplant rejection Transplant |
