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Intravascular Fluorescence
Intravascular fluorescence is a catheter-based molecular imaging technique that uses near-infrared fluorescence to detect artery wall autofluorescence (NIRAF) or fluorescence generated by molecular agents injected intravenously (NIRF) . No commercial systems based on intravascular fluorescence are currently on the market, however, significant steps forwards in intravascular fluorescence imaging technology have been made between 2010-2016. It is typically used to detect functional state of artery wall including some known high-risk features of atherosclerosis (e.g., inflammation). It is usually combined with structural imaging modalities such as Intravascular ultrasound and/or Intracoronary optical coherence tomography, to provide functional information in a morphological context. Methods Intravascular fluorescence typically used laser-induced fluorescence to stimulate fluorescence emission of particular vessel wall and plaque components or previously injected molecular agents (i.e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intracoronary Optical Coherence Tomography
Endoscopic optical coherence tomography, also intravascular optical coherence tomography is a catheter-based imaging application of optical coherence tomography (OCT). It is capable of acquiring high-resolution images from inside a blood vessel using optical fibers and laser technology. One of its main applications is for coronary arteries, which are often treated by endoscopic, minimally invasive surgical procedures. Other applications for peripheral arteries and for neurovascular procedures have been proposed and are being investigated. Neurovascular applications required significant technological developments, due to the highly tortuous anatomy of the cerebrovasculature. Intravascular OCT rapidly creates three-dimensional images at a resolution of approximately 15 micrometers, an improved resolution with respect to intravascular ultrasound and coronary angiogram, the other imaging techniques. This offers additional information that can be used to optimize the treatment an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optical Fiber
An optical fiber, or optical fibre, is a flexible glass or plastic fiber that can transmit light from one end to the other. Such fibers find wide usage in fiber-optic communications, where they permit transmission over longer distances and at higher Bandwidth (computing), bandwidths (data transfer rates) than electrical cables. Fibers are used instead of metal wires because signals travel along them with less Attenuation, loss and are immune to electromagnetic interference. Fibers are also used for illumination (lighting), illumination and imaging, and are often wrapped in bundles so they may be used to carry light into, or images out of confined spaces, as in the case of a fiberscope. Specially designed fibers are also used for a variety of other applications, such as fiber optic sensors and fiber lasers. Glass optical fibers are typically made by Drawing (manufacturing), drawing, while plastic fibers can be made either by drawing or by extrusion. Optical fibers typically incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guillermo J
Guillermo () is the Spanish form of the male given name William. The name is also commonly shortened to 'Guille' or, in Latin America, to nickname 'Memo'. People * Guillermo Amador (born 1974), American musician *Guillermo Amor (born 1967), Spanish football manager and former player *Guillermo Arévalo (born 1952), a Shipibo shaman and ''curandero'' (healer) of the Peruvian Amazon; among the Shipibo he is known as Kestenbetsa *Guillermo Barros Schelotto (born 1973), Argentine former football player * Guillermo Bermejo (born 1975), Peruvian politician * Guillermo C. Blest (1800–1884), Anglo-Irish physician settled in Chile *Guillermo Cañas, Argentine tennis player * Guillermo Chong, Chilean geologist *Guillermo Coria, another Argentine tennis player *Guillermo Dávila, Venezuelan actor and singer *Guillermo Díaz (actor) (born 1975), American actor of Cuban descent *Guillermo Diaz (basketball), Puerto Rican basketball player for the Los Angeles Clippers *Guillermo del Toro, Mexic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ughi GJ
Giovanni J. Ughi (born Padova, Italy), engineer and scientist, contributed to the invention of multimodality optical coherence tomography (OCT) and Laser-induced fluorescence molecular imaging, pioneering a first-in-man study of coronary arteries during his work at Massachusetts General Hospital and Harvard Medical School. The results of his work, combining two imaging technologies, may better identify dangerous coronary plaques, responsible for coronary artery disease and myocardial infarction. He also contributed to the development of targeted molecular imaging of human atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by development of abnormalities called lesions in walls of arteries. This is a chronic inflammatory disease involving many different cell types and is driven by eleva ..., determining the use of molecular agents (e.g., indocyanine green (ICG)-enhanced near-infrared fluorescence) to illuminate high-risk features of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thrombosis
Thrombosis () is the formation of a Thrombus, blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot, or a piece of the clot, that breaks free and begins to travel around the body is known as an embolus. Thrombosis can cause serious conditions such as stroke and heart attack. Thrombosis may occur in veins (venous thrombosis) or in arteries (arterial thrombosis). Venous thrombosis (sometimes called DVT, deep vein thrombosis) leads to a blood clot in the affected part of the body, while arterial thrombosis (and, rarely, severe venous thrombosis) affects the blood supply and leads to damage of the tissue supplied by that artery (ischemia and necrosis). A piece of either an arterial or a v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrin
Fibrin (also called Factor Ia) is a fibrous protein, fibrous, non-globular protein involved in the Coagulation, clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerization, polymerize. The polymerized fibrin, together with platelets, forms a hemostasis, hemostatic plug or clot over a wound site. When the lining of a blood vessel is broken, platelets are attracted, forming a platelet plug. These platelets have thrombin receptors on their surfaces that bind serum thrombin molecules, which in turn convert soluble fibrinogen in the serum into fibrin at the wound site. Fibrin forms long strands of tough insoluble protein that are bound to the platelets. Factor XIII completes the cross-linking of fibrin so that it hardens and contracts. The cross-linked fibrin forms a mesh atop the platelet plug that completes the clot. Fibrin was discovered by Marcello Malpighi in 1666. Role in disease Excessive generation of fibrin due ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stroke
Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly. Signs and symptoms of stroke may include an hemiplegia, inability to move or feel on one side of the body, receptive aphasia, problems understanding or expressive aphasia, speaking, dizziness, or homonymous hemianopsia, loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than 24 hours, the stroke is a transient ischemic attack (TIA), also called a mini-stroke. subarachnoid hemorrhage, Hemorrhagic stroke may also be associated with a thunderclap headache, severe headache. The symptoms of stroke can be permanent. Long-term complications may include pneumonia and Urinary incontinence, loss of b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indocyanine Green
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, liver and gastric blood flow, and for ophthalmic and cerebral angiography.Definition of indocyanine green It has a peak spectral absorption at about 800 nm. These frequencies penetrate |
Percutaneous Coronary Intervention
Percutaneous coronary intervention (PCI) is a minimally invasive non-surgical procedure used to treat stenosis, narrowing of the coronary artery, coronary arteries of the heart found in coronary artery disease. The procedure is used to place and deploy coronary stents, a permanent wire-meshed tube, to open narrowed coronary arteries. PCI is considered 'non-surgical' as it uses a small hole in a peripheral artery (leg/arm) to gain access to the arterial system; an equivalent surgical procedure would involve the opening of the chest wall to gain access to the heart area. The term 'coronary angioplasty with stent' is synonymous with PCI. The procedure visualises the blood vessels via Fluoroscopy, fluoroscopic imaging and contrast dyes. PCI is performed by an interventional cardiologists in a catheterization laboratory setting. Patients who undergo PCI broadly fall into two patient groups. Those who are suffering from a heart attack and are in a critical care emergency room setting an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lumen (anatomy)
In biology, a lumen (: lumina) is the inside space of a tubular structure, such as an artery or intestine. It comes . It can refer to: *the interior of a vessel, such as the central space in an artery, vein or capillary through which blood flows *the interior of the gastrointestinal tract *the pathways of the bronchi in the lungs *the interior of renal tubules and urinary collecting ducts *the pathways of the female genital tract, starting with a single pathway of the vagina, splitting up in two lumina in the uterus, both of which continue through the fallopian tubes *the fluid-filled cavity forming in the blastocyst during pre-implantation development called the blastocoel In cell biology, lumen is a membrane-defined space that is found inside several organelles, cellular components, or structures, including thylakoid, endoplasmic reticulum, Golgi apparatus, lysosome, mitochondrion, and microtubule. Transluminal procedures ''Transluminal procedures'' are procedures occur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catheters
In medicine, a catheter ( ) is a thin tube made from medical grade materials serving a broad range of functions. Catheters are medical devices that can be inserted in the body to treat diseases or perform a surgical procedure. Catheters are manufactured for specific applications, such as cardiovascular, urological, gastrointestinal, neurovascular and ophthalmic procedures. The process of inserting a catheter is called ''catheterization''. In most uses, a catheter is a thin, flexible tube (''soft'' catheter) though catheters are available in varying levels of stiffness depending on the application. A catheter left inside the body, either temporarily or permanently, may be referred to as an "indwelling catheter" (for example, a peripherally inserted central catheter). A permanently inserted catheter may be referred to as a "permcath" (originally a trademark). Catheters can be inserted into a body cavity, duct, or vessel, brain, skin or adipose tissue. Functionally, they allow dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Imaging
Molecular imaging is a field of medical imaging that focuses on imaging molecules of medical interest within living patients. This is in contrast to conventional methods for obtaining molecular information from preserved tissue samples, such as histology. Molecules of interest may be either ones produced naturally by the body, or synthetic molecules produced in a laboratory and injected into a patient by a doctor. The most common example of molecular imaging used clinically today is to inject a contrast agent (e.g., a microbubble, metal ion, or radioactive isotope) into a patient's bloodstream and to use an imaging modality (e.g., ultrasound, MRI, CT, PET) to track its movement in the body. Molecular imaging originated from the field of radiology from a need to better understand fundamental molecular processes inside organisms in a noninvasive manner. The ultimate goal of molecular imaging is to be able to noninvasively monitor all of the biochemical processes occurring inside ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
