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Ian Wilmut
Sir Ian Wilmut (7 July 1944 – 10 September 2023) was a British embryologist and the chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He was the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. Wilmut was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. He, Keith Campbell and Shinya Yamanaka jointly received the 2008 Shaw Prize for Medicine and Life Sciences for their work on cell differentiation in mammals. Early life and education Wilmut was born in Hampton Lucy, Warwickshire, England, on 7 July 1944. Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years, which eventually caused him to become blind. The younger Wilmut attended the Boys' High School in Scarborough, where his father taught. His early desire was to embark on a naval career, but he was unabl ...
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Professor
Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a 'person who professes'. Professors are usually experts in their field and teachers of the highest rank. In most systems of List of academic ranks, academic ranks, "professor" as an unqualified title refers only to the most senior academic position, sometimes informally known as "full professor". In some countries and institutions, the word ''professor'' is also used in titles of lower ranks such as associate professor and assistant professor; this is particularly the case in the United States, where the unqualified word is also used colloquially to refer to associate and assistant professors as well, and often to instructors or lecturers. Professors often conduct original research and commonly teach undergraduate, Postgraduate educa ...
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Finnish Dorset
The Finn-Dorset or Finn Dorset is a British and Irish sheep, a cross-breed of the Finnsheep with the Dorset Horn.Finn Dorsets and related cross-breeds have been bred for the properties of the Finnsheep's prolificacy and the Dorset's meat conformation. Dolly the sheep, first mammal to be cloned from an adult somatic cell In cellular biology, a somatic cell (), or vegetal cell, is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Somatic cells compose the body of an organism ..., was a Finn Dorset. References Sheep breeds Mammal hybrids Crossbreeds {{sheep-stub ...
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Doctor Of Philosophy
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original research. The name of the degree is most often abbreviated PhD (or, at times, as Ph.D. in North American English, North America), pronounced as three separate letters ( ). The University of Oxford uses the alternative abbreviation "DPhil". PhDs are awarded for programs across the whole breadth of academic fields. Since it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and, in some cases, defend their work before a panel of other experts in the field. In many fields, the completion of a PhD is typically required for employment as a university professor, researcher, or scientist. Definition In the context o ...
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Cryopreservation
Cryopreservation or cryoconservation is a process where biological material - cells, tissues, or organs - are frozen to preserve the material for an extended period of time. At low temperatures (typically or using liquid nitrogen) any cell metabolism which might cause damage to the biological material in question is effectively stopped. Cryopreservation is an effective way to transport biological samples over long distances, store samples for prolonged periods of time, and create a bank of samples for users. Molecules, referred to as cryoprotective agents (CPAs), are added to reduce the osmotic shock and physical stresses cells undergo in the freezing process. Some cryoprotective agents used in research are inspired by plants and animals in nature that have unique cold tolerance to survive harsh winters, including: trees, wood frogs, and tardigrades. The first human corpse to be frozen with the hope of future resurrection was James Bedford's, a few hours after his c ...
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Agriculture
Agriculture encompasses crop and livestock production, aquaculture, and forestry for food and non-food products. Agriculture was a key factor in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that enabled people to live in the cities. While humans started gathering grains at least 105,000 years ago, nascent farmers only began planting them around 11,500 years ago. Sheep, goats, pigs, and cattle were domesticated around 10,000 years ago. Plants were independently cultivated in at least 11 regions of the world. In the 20th century, industrial agriculture based on large-scale monocultures came to dominate agricultural output. , small farms produce about one-third of the world's food, but large farms are prevalent. The largest 1% of farms in the world are greater than and operate more than 70% of the world's farmland. Nearly 40% of agricultural land is found on farms larger than . However, five of every six farm ...
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Color Blindness
Color blindness, color vision deficiency (CVD) or color deficiency is the decreased ability to color vision, see color or differences in color. The severity of color blindness ranges from mostly unnoticeable to full absence of color perception. Color blindness is usually a Sex linkage, sex-linked Heredity, inherited problem or variation in the functionality of one or more of the three classes of cone cells in the retina, which mediate color vision. The most common form is caused by a genetic condition called congenital red–green color blindness (including protan and deutan types), which affects ''up to'' 1 in 12 males (8%) and 1 in 200 females (0.5%). The condition is more prevalent in males, because the opsin genes responsible are located on the X chromosome. Rarer genetic conditions causing color blindness include congenital blue–yellow color blindness (tritan type), blue cone monochromacy, and achromatopsia. Color blindness can also result from physical or chemical dam ...
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Scarborough, North Yorkshire
Scarborough () is a seaside town and civil parish in North Yorkshire District, the district and North Yorkshire, county of North Yorkshire, England. With a population of 61,749, Scarborough is the largest town on the Yorkshire Coast and the North Yorkshire#Settlements, fourth-largest settlement in the county. It is located on the North Sea coastline. Historic counties of England, Historically in the North Riding of Yorkshire, the town lies between 10 and 230 feet (3–70 m) above sea level, from the harbour rising steeply north and west towards limestone cliffs. The older part of the town lies around the harbour and is protected by a rocky headland which extends into the North Sea. The town has fishing and service industries, including a growing digital and creative economy, as well as being a tourist destination. Residents of the town are known as Scarborians. Etymology Scarborough was founded by Danes in the 10th century, when Thorgil (also known as Skarthi, meaning 'hare ...
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Graham School (Scarborough, England)
Graham School is a coeducational secondary school in Scarborough, England. It is situated to the west of the town within of grounds. The school is on Woodlands Drive. The lower site on Lady Edith's Drive closed on 23 June 2017. Graham School provides for pupils aged 11 to 16 (year 7 to year 11) History The school is named after Mr C C Graham, Mayor of Scarborough between 1913 and 1919. Grammar school Prior to 1973, the buildings were used by Scarborough High School for Boys, a boys' grammar school. The present building designed by Keith Scott of Building Design Partnership's Preston office, was built by the North Riding Education Committee in the late 1950s, around the same time as Scarborough Technical College (now called Yorkshire Coast College). It had around 700 boys in the early 1970s. Comprehensive Only the first year was all-ability when it opened. Gradually over four years from 1973 it became a comprehensive. The former site of the Scarborough Girls' High School on ...
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Diabetes
Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of the body becoming unresponsive to insulin's effects. Classic symptoms include polydipsia (excessive thirst), polyuria (excessive urination), polyphagia (excessive hunger), weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Diabetes accounts for approximately 4.2 million deaths every year, with an estimated 1.5 million caused by either untreated or poorly treated diabetes. The major types of diabetes are type 1 and type 2. The most common treatment for type 1 is insulin replacement therapy (insulin injections), while anti-diabetic medications (such as metformin and semaglutide) and lifestyle modificatio ...
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Warwickshire
Warwickshire (; abbreviated Warks) is a Ceremonial counties of England, ceremonial county in the West Midlands (region), West Midlands of England. It is bordered by Staffordshire and Leicestershire to the north, Northamptonshire to the east, Oxfordshire and Gloucestershire to the south, and Worcestershire and the West Midlands (county), West Midlands county to the west. The largest settlement is Nuneaton and the county town is Warwick. The county is largely rural; it has an area of and a population of 571,010. After Nuneaton (88,813), the largest settlements are Rugby, Warwickshire, Rugby (78,125), Leamington Spa (50,923), Warwick (36,665), Bedworth (31,090) and Stratford-upon-Avon (30,495). For Local government in England, local government purposes, Warwickshire is a non-metropolitan county with five districts. The county Historic counties of England, historically included the city of Coventry and the area to its west, including Royal Town of Sutton Coldfield, Sutton Coldfield ...
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Cell Differentiation
Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of Tissue (biology), tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated Cell division, daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolism, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Metabolic composition, however ...
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Shinya Yamanaka
is a Japanese stem cell researcher and a Nobel Prize laureate. He is a professor and the director emeritus of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application, Kyoto University; as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR). He received the 2010 BBVA Foundation Frontiers of Knowledge Award in the biomedicine category, the 2011 Wolf Prize in Medicine with Rudolf Jaenisch, and the 2012 Millennium Technology Prize together with Linus Torvalds. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work. Education Yamanaka was born in Higa ...
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