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INCOVACC
iNCOVACC (codenamed BBV154) is an intranasal COVID-19 vaccine candidate developed by Bharat Biotech, American company Precision Virologics and the Washington University School of Medicine in St Louis, Missouri, United States. History Clinical trials Phase I trials On recommendation by the Subject Expert Committee (SEC) under the Indian drug regulator, the company conducted phase 1 clinical trials using 75 volunteers and submit safety and immunogenicity data for the committee's consideration before it proceeds to the second phase of the trial. Phase II and III trials On 12 August 2021, after evaluating the results of phase I trial data, the drug regulator approved for phase II/III randomized trials that involves evaluation of the immunogenicity and safety of Covaxin Covaxin (list of pharmaceutical compound number prefixes, development name, BBV152) is a Inactivated vaccine, whole inactivated virus-based COVID-19 vaccine developed by Bharat Biotech in collaboration wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Vaccine
A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 ( COVID19). Knowledge about the structure and function of previous coronaviruses causing diseases like severe acute respiratory syndrome ( SARS) and Middle East respiratory syndrome ( MERS) accelerated the development of various vaccine platforms in early 2020. In 2020, the first COVID19 vaccines were developed and made available to the public through emergency authorizations and conditional approvals. However, immunity from the vaccines wanes over time, requiring people to get booster doses of the vaccine to maintain protection against COVID19. The COVID19 vaccines are widely credited for their role in reducing the spread of COVID19 and reducing the severity and death caused by COVID19. Many countries implemented phased distribution plans that prioritized those at highest risk of comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional name 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is Contagious disease, contagious in humans. SARS‑CoV‑2 is a strain of the species ''Betacoronavirus pandemicum'' (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of Zoonosis, z ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasal Administration
Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs, such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, rescue medications for overdose and seizure emergencies, hormone treatments, nicotine nasal spray, and nasal vaccines such as live attenuated influenza vaccine. Risks Nasal septum perforation A nasal septum perforation is a medical condition in which the nasal septum, the bony/cartilaginous wall dividing the nasal cavities, develops a hole or fissure. Nasal administration may cause nasal septum perforation by gradually injuring and ulcerating the epit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasal Vaccine
A nasal vaccine is a vaccine administered through the nose that stimulates an immune response without an injection. It induces immunity through the Nasal mucosa, inner surface of the nose, a surface that naturally comes in contact with many Airborne transmission, airborne microbes. Nasal vaccines are emerging as an alternative to injectable vaccines because they do not use needles and can be introduced through the mucosal route. Nasal vaccines can be delivered through nasal sprays to prevent respiratory infections, such as influenza. History Nasal inoculation dates as far back as the 17th century in China during the Kangxi Emperor’s reign. Documentation during this period indicates that the Kangxi Emperor vaccinated his family, army, and others for mild smallpox. Manuals detailing vaccination techniques at the time all focused on sending smallpox up the nose of the individual being vaccinated. Although other vaccination techniques were developed using an infected individual’s sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bharat Biotech
Bharat Biotech International Limited (BBIL) is an Indian multinational biotechnology company based in Hyderabad, which is engaged in drug discovery, drug development, and the manufacture of vaccines, biotherapeutics, pharmaceuticals and healthcare products. Overview Bharat Biotech has its manufacturing facility situated at Genome Valley, Hyderabad, India. As of July 2020, the company has over 700 employees and has a presence worldwide. The company has been responsible for developing an eco-friendly recombinant and a naturally attenuated strain derived Rotavirus vaccine called ROTAVAC. They were one of the first to develop vaccines for viral diseases like Chikungunya and Zika. The company also produces vaccines for Japanese Encephalitis, influenza H1N1, Rabies. Bharat Biotech has biosafety level 3 (BSL3) laboratories. It has developed the world's first tetanus-toxoid conjugated vaccine for Typhoid. Bharat Biotech has delivered over nine billion doses of vaccines globally ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washington University School Of Medicine
Washington University School of Medicine (WashU Medicine) is the medical school of Washington University in St. Louis, located in the Central West End neighborhood of St. Louis, Missouri. Founded in 1891, the School of Medicine shares a campus with Barnes-Jewish Hospital, St. Louis Children's Hospital, and the Alvin J. Siteman Cancer Center. The clinical service is provided by Washington University Physicians, a comprehensive medical and surgical practice providing treatment in more than 75 medical specialties. Washington University Physicians are the medical staff of the school's two teaching hospitals – Barnes-Jewish Hospital and St. Louis Children's Hospital. They also provide inpatient and outpatient care at the St. Louis Veteran's Administration Hospital, hospitals of the BJC HealthCare system, and 35 other office locations throughout the greater St. Louis region. History Medical classes were first held at Washington University in 1891 after the St. Louis Medi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
St Louis
St. Louis ( , sometimes referred to as St. Louis City, Saint Louis or STL) is an Independent city (United States), independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi River, Mississippi and the Missouri River, Missouri rivers. In 2020, the city proper had a population of 301,578, while Greater St. Louis, its metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is the List of metropolitan areas of Missouri, largest metropolitan area in Missouri and the second-largest in Illinois. The city's combined statistical area is the 20th-largest in the United States. The land that became St. Louis had been occupied by Native Americans in the United States, Native American cultures for thousands of years before European colonization of the Americas, European settlement. The city was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. Maxent, Pierre Laclède, and Auguste Choute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Missouri
Missouri (''see #Etymology and pronunciation, pronunciation'') is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. At 1.5 billion years old, the St. Francois Mountains are among the oldest in the world. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the List of U.S. states and territories by population, 19th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Missouri, Kansas City, Springfield, Missouri, Springfield, and Columbia, Missouri, Columbia. The Cap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phase 1 Clinical Trial
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for drug safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Description Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. When expressed specifically, a clinical trial phase is capitalized both in name and Roman numeral, such as "Phase I" clinical trial. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory auth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunogenicity
Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or other animal. It may be wanted or unwanted: * Wanted immunogenicity typically relates to vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen, protecting the organism from future exposure. Immunogenicity is a central aspect of vaccine development. * Unwanted immunogenicity is an immune response by an organism against a therapeutic antigen. This reaction leads to production of anti-drug-antibodies (ADAs), inactivating the therapeutic effects of the treatment and potentially inducing adverse effects. A challenge in biotherapy is predicting the immunogenic potential of novel protein therapeutics. For example, immunogenicity data from high-income countries are not always transferable to low-income and middle-income countries. Another challenge is considering how the immunogenicity of vaccines changes wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Covaxin
Covaxin (list of pharmaceutical compound number prefixes, development name, BBV152) is a Inactivated vaccine, whole inactivated virus-based COVID-19 vaccine developed by Bharat Biotech in collaboration with the Indian Council of Medical Research - National Institute of Virology. On 3 November 2021, the World Health Organization (WHO) validated the vaccine for emergency use, as the first Indian-developed covid vaccine to be approved. By 31 January 2022, Covaxin had been granted emergency use approval in 13 countries. Medical uses Effectiveness A vaccine is generally considered effective if the estimate is ≥50% with a >30% lower limit of the 95% confidence interval. Effectiveness is generally expected to slowly decrease over time. Efficacy A phase 3 clinical trial with 25,798 participants found that the vaccine is effective against asymptomatic cases, effective against symptomatic disease, effective against severe disease, and effective against the Delta variant. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Tribune (Chandigarh)
''The Tribune'' is an Indian English-language daily newspaper published from Amritsar, Jalandhar, Ludhiana, Bathinda, Chandigarh and Gurgaon, Gurugram. It was founded on 2 February 1881, in Lahore, Punjab Province (British India), Punjab (now in Pakistan), by Sardar Dyal Singh Majithia, a philanthropist, and is run by a trust comprising five persons as trustees. It is a major Indian newspaper with a worldwide circulation. In India, it is among the leading English daily for Punjab, India, Punjab, Haryana, Himachal Pradesh, and the Chandigarh, Union Territory of Chandigarh. Overview The present Editor-in-Chief of ''The Tribune'' is Jyoti Malhotra. ''The Tribune'' has two sister publications: ''Dainik Tribune'' (in Hindi) and ''Punjabi Tribune'' (in Punjabi language, Punjabi). Naresh Kaushal is the Editor of ''Dainik Tribune'' and Arvinder Kaur Johal is the Officiating Editor of the ''Punjabi Tribune''. The online edition of ''The Tribune'' was launched in July 1998, and the onlin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
