Hp53int1
Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans. Gene The Hp53int1 gene is located on chromosome 17p.13, encoded by a DNA sequence 1125 base pairs in length, covering region 7,685,260 bp-7,686,371 bp. The Hp53int1 gene has two aliases, WRAP53int1 and TP53int1, in accordance to its overlap with the WRAP53 and TP53int1 genes on chromosome 17. Hp53int1 is located downstream of the p53p2 start site. Hp53int1 does not have multiple exons, and therefore has no isoforms. Important relationship to TP53 The Hp53int1 gene is transcribed in the same direction as TP53 and is present in TP53 protein-rich myeloid leukemia cells HL-60 and U937. This suggests a strong relationship to the TP53 gene and subsequent protein, including a share of transcription factors, promoter signals, tissue expression, and subcellular localization. While these genes are not identical, this relationship may give clues to function, structure, and expression. mRNA trans ...
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