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Homofenazine
Homofenazine is an antipsychotic drug of the phenothiazines class. It was synthesized by Wilhelm Schuler and colleagues at Degussa.. In 1966, it was released in Belgium under the brand name Pasaden. At some point, it was quietly discontinued and is no longer marketed. Synthesis The alkylation between 2-(Trifluoromethyl)Phenothiazine 2-30-8(1) and 1-(3-bromopropyl)-1,4-diazepane (2) led to 10- -(1,4-diazepan-1-yl)propyl2-(trifluoromethyl)phenothiazineCID:110174391(3). Further alkylation with 2-Chloroethanol 2-Chloroethanol (also called ethylene chlorohydrin or glycol chlorohydrin) is an organic chemical compound with the chemical formula HOCH2CH2Cl and the ''simplest'' beta-halohydrin (chlorohydrin). This colorless liquid has a pleasant ether-like od ... 07-07-3(4) completed the synthesis of homofenazine (5). References {{reflist Typical antipsychotics Phenothiazines Diazepanes Trifluoromethyl compounds Ethanolamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jornal Do Brasil
''Jornal do Brasil'', widely known as ''JB'', is a daily newspaper published by Editora JB in Rio de Janeiro, Brazil. The paper was founded in 1891 and is the third oldest extant Brazilian paper, after the ''Diário de Pernambuco'' and ''O Estado de S. Paulo''. On 31 August 2010 it became a digital newspaper, folding its print edition until 25 February 2018, when it was printed again. History It is often believed that the newspaper was founded by former supporters of the deposed monarchy and sported conservative views in its early decades. However at the time, the monarchy was leading the fight for the end of slavery so can be considered liberal for the period. Many important Brazilian writers and journalists eventually worked for ''Jornal do Brasil'', especially after the 1964 coup d'état. ''Jornal do Brasil'' was an important opponent for challenging censorship although it never was radically against the dictatorship and its editors did not follow a rebellious line against th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diário Oficial Da União
The ''Diário Oficial da União'' (literally ''Official Diary of the Union''), abbreviated DOU, is the government gazette, official gazette of the Federal Government of Brazil, Federal Government of Brazil. It is published since 1 October 1862 and was created via the Imperial Decree 1,177 of its 9 September as the ''Official Journal of the Empire of Brazil''. Its current name was adopted after Brazil became a federal republic, and the "Union" came into being as the legal personality of the new federal government. The official journal is published by the Imprensa Nacional, Brazilian National Press. Though the journal has been published since 1862, it had many predecessors, as follows: # Gazeta do Rio de Janeiro (10/9/1808 – 29.12.1821) # Gazeta do Rio (1/1/1822 – 31/12/1822) # Diário do Governo (2/1/1823 – 28/6/1833) # Diário Fluminense (21/5/1824 – 24/4/1831) # Correio Oficial (1/7/1833 – 30/6/1836) e (2/1/1830 – 30/12/1840) # Without proper journal (31/12/1840 – ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipsychotic Drug
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay, together with mood stabilizers, in the treatment of bipolar disorder. Moreover, they are also used as adjuncts in the treatment of Treatment-resistant depression, treatment-resistant major depressive disorder. The use of antipsychotics may result in many unwanted side effects such as Extrapyramidal symptoms, involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce List of long term side effects of antipsychotics, adverse effects such as tardive dyskinesia, tardive dystonia, Akathisia, tardive akathisia, and brain tissue volume reduction. The long term use of antipsychotics often changes the bra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenothiazine
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivatives chlorpromazine and promethazine revolutionized the fields of psychiatry and allergy treatment, respectively. An earlier derivative, methylene blue, was one of the first antimalarial drugs, and derivatives of phenothiazine are currently under investigation as possible anti-infective drugs. Phenothiazine is a prototypical pharmaceutical lead structure in medicinal chemistry. Uses Phenothiazine itself is only of theoretical interest, but derivatives of it revolutionized psychiatry, other fields of medicine, and pest management. Other derivatives have been studied for possible use in advanced batteries and fuel cells. Phenothiazine-derived drugs In 1876, methylene blue, a derivative of phenothiazine, was synthesized by H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wilhelm Schuler
Wilhelm Alfons Schuler (27 December 1914 in Ulm, Germany – 5 June 2010 in Bad Homburg vor der Höhe, Germany) was a chemist, inventor and entrepreneur in the second half of the 20th century. Biography Schuler studied chemistry at the Königliche Technische Hochschule zu Danzig from 1934 onwards. After he obtained the title of Diplomchemiker (~Master of Chemistry) in 1939 he was drafted to the Wehrmacht. Just after 6 months of service he was discharged after Paul Rabe (Universität Hamburg) requested Schuler for important research projects in the field of pharmaceutical ingredients at the University of Danzig. Schuler worked in the research group of Henry Albers studying organic phosphorus compounds. In 1941 he received his PhD. He remained at the University of Danzig as assistant to Henry Albers, working on alkaloids.Paul Rabe and Wilhelm Schuler: ''Die Synthese der 6'-Methoxy-9-oxy-rubane – ein Beitrag zur Wirkungsweise des Chinins und der Chinidine'', Berichte der deutschen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Degussa
{{Infobox company , name = Evonik Industries AG , logo = Logo Evonik 2020.svg , image = RellingHaus II, Essen.jpg , image_caption = Evonik's headquarters in Essen, Germany , type = Aktiengesellschaft , traded_as = {{Frankfurt Stock Exchange, EVK MDAX Component , industry = Specialty chemicals , key_people = {{plainlist , * Christian Kullmann {{small, (CEO, Chairman) * Bernd Tönjes (Chairman of the supervisory board) , products = Chemicals , revenue = {{Decrease €15.2 billion (2024){{cite web , url= https://www.evonik.com/en/investor-relations/Reporting.html#tabs-b118b10b7a-item-2d4ab0c2ad-tab , title=Evonik Financial Report 2024 , publisher=Evonik Industries AG , access-date=1 April 2025 , net_income = {{Decrease €222 million (2024) , num_employees = 31,930 (2024) , foundation = {{start date and age, df=yes, 2007 , location = Essen, Germany , homepage = www.evonik.c Evonik Industries AG is a publicly-listed German specialty Chemical substance, chemicals compa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Belgium
Belgium, officially the Kingdom of Belgium, is a country in Northwestern Europe. Situated in a coastal lowland region known as the Low Countries, it is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to the south, and the North Sea to the west. Belgium covers an area of and has a population of more than 11.8 million; its population density of ranks List of countries and dependencies by population density, 22nd in the world and Area and population of European countries, sixth in Europe. The capital and Metropolitan areas in Belgium, largest metropolitan region is City of Brussels, Brussels; other major cities are Antwerp, Ghent, Charleroi, Liège, Bruges, Namur, and Leuven. Belgium is a parliamentary system, parliamentary constitutional monarchy with a complex Federation, federal system structured on regional and linguistic grounds. The country is divided into three highly autonomous Communities, regions and language areas o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-Chloroethanol
2-Chloroethanol (also called ethylene chlorohydrin or glycol chlorohydrin) is an organic chemical compound with the chemical formula HOCH2CH2Cl and the ''simplest'' beta-halohydrin (chlorohydrin). This colorless liquid has a pleasant ether-like odor. It is miscible with water. The molecule is bifunctional, consisting of both an alkyl chloride and an alcohol functional group. Synthesis and applications 2-Chloroethanol is produced by treating ethylene with hypochlorous acid: : 2-Chloroethanol was once produced on a large scale as a precursor to ethylene oxide: : :HOCH2CH2Cl + NaOH → C2H4O + NaCl + H2O This application has been supplanted by the more economic direct oxidation of ethylene. Otherwise chloroethanol is still used in the production of pharmaceuticals, biocides, and plasticizers. Many of these applications entail its use in installing 2-hydroxyethyl groups. Several dyes are prepared by the alkylation of aniline derivatives with chloroethanol. It is also used for manuf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Typical Antipsychotics
Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions. The first typical antipsychotics to come into medical use were the phenothiazines, namely chlorpromazine which was discovered serendipitously. Another prominent grouping of antipsychotics are the butyrophenones, an example of which is haloperidol. The newer, second-generation antipsychotics, also known as atypical antipsychotics, have largely supplanted the use of typical antipsychotics as first-line agents due to the higher risk of movement disorders with typical antipsychotics. Both generations of medication tend to block receptors in the brain's dopamine pathways, but atypicals at the time of marketing were claimed to differ from typical antipsychoti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenothiazines
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivatives chlorpromazine and promethazine revolutionized the fields of psychiatry and allergy treatment, respectively. An earlier derivative, methylene blue, was one of the first antimalarial drugs, and derivatives of phenothiazine are currently under investigation as possible anti-infective drugs. Phenothiazine is a prototypical pharmaceutical lead structure in medicinal chemistry. Uses Phenothiazine itself is only of theoretical interest, but derivatives of it revolutionized psychiatry, other fields of medicine, and pest management. Other derivatives have been studied for possible use in advanced batteries and fuel cells. Phenothiazine-derived drugs In 1876, methylene blue, a derivative of phenothiazine, was synthesized by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
