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Herbert Zimmermann (neuroscientist)
Herbert Zimmermann (born 10 January 1944) is a German neuroscientist who pioneered the studies on the biochemical, structural and functional heterogeneity of cholinergic synaptic vesicles from the electric organ of the electric ray Torpedo, and the functional and biochemical characterization of enzymes hydrolyzing extracellular nucleotides. Biography Herbert Zimmermann was born in Chiesch (now Chyše, Czech Republic). He studied chemistry and biology at the Ludwig Maximilian University of Munich (1964–69) and obtained his PhD at the University of Regensburg in 1971. From 1972-73 he continued as postdoctoral fellow at the Department of Biochemistry at the University of Cambridge, UK. From 1973-79 he was scientist and senior scientist at the Department of Neurochemistry of the Max Planck Institute for Biophysical Chemistry in Göttingen (Germany). From 1980–83 he held the position of Professor of Neurobiology at the University of Oldenburg (Germany). In 1983 he was appo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tokyo Daigaku
, abbreviated as or UTokyo, is a public research university located in Bunkyō, Tokyo, Japan. Established in 1877, the university was the first Imperial University and is currently a Top Type university of the Top Global University Project by the Japanese government. UTokyo has 10 faculties, 15 graduate schools and enrolls about 30,000 students, about 4,200 of whom are international students. In particular, the number of privately funded international students, who account for more than 80%, has increased 1.75 times in the 10 years since 2010, and the university is focusing on supporting international students. Its five campuses are in Hongō, Komaba, Kashiwa, Shirokane and Nakano. It is considered to be the most selective and prestigious university in Japan. As of 2021, University of Tokyo's alumni, faculty members and researchers include seventeen prime ministers, 18 Nobel Prize laureates, four Pritzker Prize laureates, five astronauts, and a Fields Medalist. History ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italy
Italy ( it, Italia ), officially the Italian Republic, ) or the Republic of Italy, is a country in Southern Europe. It is located in the middle of the Mediterranean Sea, and its territory largely coincides with the homonymous geographical region. Italy is also considered part of Western Europe, and shares land borders with France, Switzerland, Austria, Slovenia and the enclaved microstates of Vatican City and San Marino. It has a territorial exclave in Switzerland, Campione. Italy covers an area of , with a population of over 60 million. It is the third-most populous member state of the European Union, the sixth-most populous country in Europe, and the tenth-largest country in the continent by land area. Italy's capital and largest city is Rome. Italy was the native place of many civilizations such as the Italic peoples and the Etruscans, while due to its central geographic location in Southern Europe and the Mediterranean, the country has also historically b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferrara
Ferrara (, ; egl, Fràra ) is a city and ''comune'' in Emilia-Romagna, northern Italy, capital of the Province of Ferrara. it had 132,009 inhabitants. It is situated northeast of Bologna, on the Po di Volano, a branch channel of the main stream of the Po River, located north. The town has broad streets and numerous palaces dating from the Renaissance, when it hosted the court of the House of Este. For its beauty and cultural importance, it has been designated by UNESCO as a World Heritage Site. History Antiquity and Middle Ages The first documented settlements in the area of the present-day Province of Ferrara date from the 6th century BC. The ruins of the Etruscan town of Spina, established along the lagoons at the ancient mouth of Po river, were lost until modern times, when drainage schemes in the Valli di Comacchio marshes in 1922 first officially revealed a necropolis with over 4,000 tombs, evidence of a population centre that in Antiquity must have played a major r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geoffrey Burnstock
Geoffrey Burnstock (10 May 1929 – 2 June 2020) was a neurobiologist and President of the Autonomic Neuroscience Centre of the UCL Medical School. He is best known for coining the term purinergic signalling, which he discovered in the 1970s. He retired in October 2017 at the age of 88. Life and career Burnstock was educated at Greenford County School, King's College London (BSc, 1953) and at University College London (PhD, 1957). He played a key role in the discovery of ATP as neurotransmitter. He was appointed to a Senior Lectureship in Melbourne University in 1959 and became Professor and Chairman of Zoology in 1964. In 1975, he became Head of Department of Anatomy and Developmental Biology at UCL and Convenor of the Center of Neuroscience. He has been Director of the Autonomic Neuroscience Institute at the Royal Free Hospital School of Medicine since 1997. He was elected to the Australian Academy of Science in 1971, the Royal Society in 1986, the International ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammalian Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head (cephalization), usually near organs for special senses such as vision, hearing and olfaction. Being the most specialized organ, it is responsible for receiving information from the sensory nervous system, processing those information (thought, cognition, and intelligence) and the coordination of motor control (muscle activity and endocrine system). While invertebrate brains arise from paired segmental ganglia (each of which is only responsible for the respective body segment) of the ventral nerve cord, vertebrate brains develop axially from the midline dorsal nerve cord as a vesicular enlargement at the rostral end of the neural tube, with centralized control over all body segments. All vertebrate brains can be embryonically divided into three parts: the forebrain (prosencephalon, subdi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adult Neurogenesis
Adult neurogenesis is the process in which neurons are generated from neural stem cells in the adult. This process differs from prenatal neurogenesis. In most mammals, new neurons are born throughout adulthood in two regions of the brain: * The subgranular zone (SGZ), part of the dentate gyrus of the hippocampus, where neural stem cells give birth to granule cells (implicated in memory formation and learning). * The subventricular zone (SVZ) of the lateral ventricles, which can be divided into three microdomains: lateral, dorsal and medial. Neural stem cells migrate to the olfactory bulb through the rostral migratory stream where they differentiate into interneurons participating in the sense of smell. In humans, however, few if any olfactory bulb neurons are generated after birth. More attention has been given to the neurogenesis in the dentate gyrus than in the striatum. In rodents, many of the newborn dentate gyrus neurons die shortly after they are born, but a number of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purinergic Signalling
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular cell signaling, signalling mediated by purine nucleotides and nucleosides such as adenosine and Adenosine triphosphate, ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cell (biology), cellular functions. The purinergic signalling complex of a cell is sometimes referred to as the “purinome”. Background Evolutionary origins Purinergic receptors, represented by several families, are among the most abundant receptors in living organisms and appeared early in evolution. Among invertebrates, the purinergic signalling system has been found in bacteria, amoeba, ciliates, algae, fungi, anemones, ctenophores, platyhelminthes, nematodes, crustacea, molluscs, annelids, echinoderms, and insects. In green plants, extracellular ATP and other nucleotides induce an increase in the cytosolic concentration of calcium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleosides
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups. In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building-blocks of DNA and RNA. List of nucleosides and corresponding nucleobases The reason for 2 symbols, shorter and longer, is that the shorter ones are better for contexts where explicit disambiguation is superfluous (because context disambiguates) and the longer ones are for contexts where explicit disambiguation is judged to be needed or wise. For example, when discussing long nucleobase sequences in genomes, the CATG symbol system is much preferable to the Cyt-Ade-Thy-Gua symbol system (see '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenosine
Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside building blocks of RNA (and its derivative deoxyadenosine is a building block of DNA), which are essential for all life. Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine monophosphate (cAMP) is pervasive in signal transduction. Adenosine is used as an intravenous medication for some cardiac arrhythmias. Adenosyl (abbreviated Ado or 5'-dAdo) is the chemical group formed by removal of the 5′-hydroxy (OH) group. It is found in adenosylcobalamin (an active form of vitamin B12) and as a radical in radical SAM enzymes. Medical uses Supraventricular tachycardia In individuals with supraventricular tachycardia (SVT), adenosine is used to help identify and convert t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience (journal)
''Neuroscience'' is a peer-reviewed scientific journal of neuroscience. It was established in 1976 with P.G. Kostyuk, Rodolfo Llinás, and A.D. Smith as founding editors-in-chief and originally published by Pergamon Press. The current editor-in-chief is Juan Lerma Gómez (Spanish National Research Council). The journal is published by Elsevier on behalf of the International Brain Research Organization (IBRO). The journal continues the IBRO News section formerly published in '' Brain Research''. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', ''Neuroscience'' has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 3.590. Notable articles , the following articles are the most downloaded accor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenosine Triphosphate
Adenosine triphosphate (ATP) is an organic compound that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP. The human body recycles its own body weight equivalent in ATP each day. It is also a precursor to DNA and RNA, and is used as a coenzyme. From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base ( adenine), the sugar ribose, and the triphosphate. Structure ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar ( ribose), which in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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