|
Herbert Tabor
Herbert Tabor (November 28, 1918 – August 20, 2020) was an American biochemist and physician-scientist who specialized in the function of polyamines and their role in human health and disease. Tabor was a principal investigator at the National Institute of Diabetes and Digestive and Kidney Diseases where he was Chief of the Laboratory of Biochemical Pharmacology. He was the editor-in-chief of the ''Journal of Biological Chemistry'' from 1971 to 2010. Education Tabor was born in New York City in 1918. Tabor received a Bachelor of Arts at Harvard College in 1937 and a Doctor of Medicine at Harvard Medical School (HMS) in 1941. He was a researcher in the department of biological chemistry at HMS in 1941. Tabor worked in the lab of John Peters researching a carbon monoxide method to measure blood volumes while he completed a medical internship at Yale New Haven Hospital from 1942 to 1943. Career Tabor was a principal investigator at the National Institute of Diabetes and Diges ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City, New York
New York, often called New York City (NYC), is the List of United States cities by population, most populous city in the United States, located at the southern tip of New York State on New York Harbor, one of the world's largest natural harbors. The city comprises boroughs of New York City, five boroughs, each coextensive with List of counties in New York, a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global city, global center of financial center, finance and Economy of New York City, commerce, Culture of New York City, culture, high technology, technology, The Entertainment Capital of the World, entertainment and Media in New York City, media, Academy, academics, and List of cities by scientific output, scientific output, the The arts, arts and fashion capital, fashion, and, as hom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amine
In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of electrons. Amines can also exist as hetero cyclic compounds. Aniline is the simplest aromatic amine, consisting of a benzene ring bonded to an amino group. Amines are classified into three types: primary (1°), secondary (2°), and tertiary (3°) amines. Primary amines (1°) contain one alkyl or aryl substituent and have the general formula RNH2. Secondary amines (2°) have two alkyl or aryl groups attached to the nitrogen atom, with the general formula R2NH. Tertiary amines (3°) contain three substituent groups bonded to the nitrogen atom, and are represented by the formula R3N. The functional group present in primary amines is called the amino group. Classification of amines Amines can be classified according to the nature and number o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biochemists
File:1st century collage.png, From top left, clockwise: Jesus is crucified by Roman authorities in Judaea (17th century painting). Four different men ( Galba, Otho, Vitellius, and Vespasian) claim the title of Emperor within the span of a year; The Great Fire of Rome (18th-century painting) sees the destruction of two-thirds of the city, precipitating the empire's first persecution against Christians, who are blamed for the disaster; The Roman Colosseum is built and holds its inaugural games; Roman forces besiege Jerusalem during the First Jewish–Roman War (19th-century painting); The Trưng sisters lead a rebellion against the Chinese Han dynasty (anachronistic depiction); Boudica, queen of the British Iceni leads a rebellion against Rome (19th-century statue); Knife-shaped coin of the Xin dynasty., 335px rect 30 30 737 1077 Crucifixion of Jesus rect 767 30 1815 1077 Year of the Four Emperors rect 1846 30 3223 1077 Great Fire of Rome rect 30 1108 1106 2155 Boudican re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2020 Deaths
This is a list of lists of deaths of notable people, organized by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked below. 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Earlier years ''Deaths in years earlier than this can usually be found in the main articles of the years.'' See also * Lists of deaths by day * Deaths by year (category) {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1918 Births
The ceasefire that effectively ended the First World War took place on the eleventh hour of the eleventh day of the eleventh month of this year. Also in this year, the Spanish flu pandemic killed 50–100 million people worldwide. In Russia, this year runs with only 352 days. As the result of Julian to Gregorian calendar switch, 13 days needed to be skipped. Wednesday, January 31 ''(Julian Calendar)'' was immediately followed by Thursday, February 14 ''(Gregorian Calendar)''. Events World War I will be abbreviated as "WWI" January * January – 1918 flu pandemic: The "Spanish flu" ( influenza) is first observed in Haskell County, Kansas. * January 4 – The Finnish Declaration of Independence is recognized by Soviet Russia, Sweden, Germany and France. * January 8 – American president Woodrow Wilson presents the Fourteen Points as a basis for peace negotiations to end the war. * January 9 – Battle of Bear Valley: U.S. troops engage Yaqui Native Ameri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston Streetcar
As with many large cities, a large number of Boston-area streetcar lines once existed, and many continued operating into the 1950s. However, only a few now remain, namely the four branches of the Green Line and the Mattapan Line, with only one (the Green Line E branch) running regular service on an undivided street. History The first streetcar line in the Boston area was a horse-drawn line from Central Square, Cambridge to Bowdoin Square, Boston opened by the Cambridge Railroad on March 26, 1856. Over the following decade a large number of horsecar lines were built by different companies, including the Metropolitan Railroad, Middlesex Railroad, and South Boston Railroad; these companies competed with each other while also sharing tracks in many locations. By the mid-1860s horsecar lines reached to Lynn, Arlington, Watertown, Newton, West Roxbury, and Milton. In 1887 the various Boston-area horsecar companies (except for the Lynn and Boston Railroad) were all consol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
S-adenosylmethionine Decarboxylase
The enzyme adenosylmethionine decarboxylase () catalyzes the conversion of ''S''-adenosyl methionine to ''S''-adenosylmethioninamine. Polyamines such as spermidine and spermine are essential for cellular growth under most conditions, being implicated in many cellular processes including DNA, RNA and protein synthesis. S-adenosylmethionine decarboxylase (AdoMetDC) plays an essential regulatory role in the polyamine biosynthetic pathway by generating the n-propylamine residue required for the synthesis of spermidine and spermine from putrescein. Unlike many amino acid decarboxylases AdoMetDC uses a covalently bound pyruvate residue as a cofactor rather than the more common pyridoxal 5'-phosphate. These proteins can be divided into two main groups which show little sequence similarity either to each other, or to other pyruvoyl-dependent amino acid decarboxylases: class I enzymes found in bacteria and archaea, and class II enzymes found in eukaryotes. In both groups the activ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spermine Synthase
Spermine synthase (, ''spermidine aminopropyltransferase'', ''spermine synthetase'') is an enzyme that converts spermidine into spermine. This enzyme catalyses the following chemical reaction : S-adenosylmethioninamine + spermidine \rightleftharpoons S-methyl-5'-thioadenosine + spermine Spermine synthase is an enzyme involved in polyamine biosynthesis. It is present in all eukaryotes and plays a role in a variety of biological functions in plants Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer In biochemistry, a protein dimer is a macromolecular complex or protein multimer, multimer formed by two protein monomers, or single proteins, which are usually Non-covalent interaction, non-covalently bound. Many macromolecules, such as proteins ... formed via dimerization. The interactions between one of the three domains, the N-terminals of the monomers, is responsible for dimerization as that is where the active site is loca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spermidine Synthase
Spermidine synthase is an enzyme () that catalyzes the transfer of the propylamine group from ''S''-adenosylmethioninamine to putrescine in the biosynthesis of spermidine. The systematic name is S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase and it belongs to the group of aminopropyl transferases. It does not need any cofactors. Most spermidine synthases exist in solution as dimers. Specificity With exception of the spermidine synthases from ''Thermotoga maritimum'' and from ''Escherichia coli'', which accept different kinds of polyamines, all enzymes are highly specific for putrescine. No known spermidine synthase can use ''S''-adenosyl methionine. This is prevented by a conserved aspartatyl residue in the active site, which is thought to repel the carboxyl moiety of ''S''-adenosyl methionine. The putrescine-N-methyl transferase whose substrates are putrescine and ''S''-adenosyl methionine, and which is evolutionary related to the spermidine syntha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
