|
Henk Buck
Henk Buck (7 February 1930 – 27 November 2023) was a Dutch organic chemist. He was born in Dordrecht on 7 February 1930. Buck studied at the University of Leiden where he received his PhD in 1959. He got a lectorship at the university in Theoretical Organic Chemistry in 1964. For his research he received the Golden Medal of the Royal Netherlands Chemical Society in 1967. In 1970 he was appointed professor of Physical Organic Chemistry and Organic Chemistry at the University of Technology in Eindhoven. Because there was no chair for Theoretical Chemistry and Biochemistry he gave lectures in organic chemistry, physical organic chemistry, theoretical organic chemistry, biochemistry and biotechnology. From 1988 to 1991 he was Dean of the Chemical Faculty. For his scientific contributions he became a member of the Royal Netherlands Academy of Arts and Sciences in 1979. During his scientific career he published more than 300 scientific papers spread over a large area of the chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes Physical property, physical and Chemical property, chemical properties, and evaluation of Reactivity (chemistry), chemical reactivity to understand their behavior. The study of organic reactions includes the organic synthesis, chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical (in silico) study. The range of chemicals studied chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantum Tunneling
In physics, a quantum (: quanta) is the minimum amount of any physical entity (physical property) involved in an interaction. The fundamental notion that a property can be "quantized" is referred to as "the hypothesis of quantization". This means that the magnitude of the physical property can take on only discrete values consisting of integer multiples of one quantum. For example, a photon is a single quantum of light of a specific frequency (or of any other form of electromagnetic radiation). Similarly, the energy of an electron bound within an atom is quantized and can exist only in certain discrete values. Atoms and matter in general are stable because electrons can exist only at discrete energy levels within an atom. Quantization is one of the foundations of the much broader physics of quantum mechanics. Quantization of energy and its influence on how energy and matter interact (quantum electrodynamics) is part of the fundamental framework for understanding and describing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul S
Paul may refer to: People * Paul (given name), a given name, including a list of people * Paul (surname), a list of people * Paul the Apostle, an apostle who wrote many of the books of the New Testament * Ray Hildebrand, half of the singing duo Paul & Paula * Paul Stookey, one-third of the folk music trio Peter, Paul and Mary * Billy Paul, stage name of American soul singer Paul Williams (1934–2016) * Vinnie Paul, drummer for American Metal band Pantera * Paul Avril, pseudonym of Édouard-Henri Avril (1849–1928), French painter and commercial artist * Paul, pen name under which Walter Scott wrote ''Paul's letters to his Kinsfolk'' in 1816 * Jean Paul, pen name of Johann Paul Friedrich Richter (1763–1825), German Romantic writer Places * Paul, Cornwall, a village in the civil parish of Penzance, United Kingdom *Paul (civil parish), Cornwall, United Kingdom * Paul, Alabama, United States, an unincorporated community *Paul, Idaho, United States, a city *Paul, Nebraska, Unit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul C
Paul C. McKasty (September 20, 1964July 17, 1989), better known as Paul C, was an American East Coast hip hop pioneer, producer, engineer, and mixer in the 1980s.Pritt Kalsi McKasty gained recognition for his work with notable artists such as Devo, Organized Konfusion, Kwamé, Queen Latifah, Biz Markie, Ultramagnetic MCs, Rahzel, and Eric B & Rakim. ''Complex'' called him "one of the most important figures in the development of sampling" and Questlove of the Roots called McKasty, "damn near the J Dilla of his day." Work Paul gave himself the middle name "Charles" after Ray Charles, which he shortened to the initial "C". He developed an interest in music from his older brother Michael, who was a guitarist, and Tim, who worked as a recording engineer at 1212 Studio in Queens. According to Paul's middle school friend TeQnotic, he was an already gifted artist and bass guitar player in junior high. McKasty began his musical career as a bassist of the pop rock band the Mandolindle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antisense Therapy
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through Splicing (genetics), splicing site binding on pre-mRNA. Several ASOs have been approved in the United States, the European Union, and elsewhere. Nomenclature The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. Antisense Oligonucleotide Development Developments in ASO modification are separated into three generations. Generation one is called backbone-modified and focuses on the phosphodiester group of the nucleotide. This impacts inter-nucleotide binding. These modifications led to better distribution, reduced urinary excretion, and prolonged residence time of the ASOs in the cell. Some exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Mechanics
Molecular mechanics uses classical mechanics to model molecular systems. The Born–Oppenheimer approximation is assumed valid and the potential energy of all systems is calculated as a function of the nuclear coordinates using Force field (chemistry), force fields. Molecular mechanics can be used to study molecule systems ranging in size and complexity from small to large biological systems or material assemblies with many thousands to millions of atoms. All-atomistic molecular mechanics methods have the following properties: * Each atom is simulated as one particle * Each particle is assigned a radius (typically the van der Waals radius), polarizability, and a constant net charge (generally derived from quantum calculations and/or experiment) * Bonded interactions are treated as ''springs'' with an equilibrium distance equal to the experimental or calculated bond length Variants on this theme are possible. For example, many simulations have historically used a ''united-atom'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleosides, Nucleotides & Nucleic Acids
''Nucleosides, Nucleotides & Nucleic Acids'' is a monthly academic journal published by Taylor & Francis Taylor & Francis Group is an international company originating in the United Kingdom that publishes books and academic journals. Its parts include Taylor & Francis, CRC Press, Routledge, F1000 (publisher), F1000 Research and Dovepress. It i ... since 2000, continuing the earlier ''Nucleosides and Nucleotides'' in series. It discusses topics relating to the biochemistry of molecules in these classes. Biochemistry journals Academic journals established in 2000 English-language journals {{biochem-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Spin Resonance
Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials that have unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spins excited are those of the electrons instead of the atomic nuclei. EPR spectroscopy is particularly useful for studying metal complexes and organic radicals. EPR was first observed in Kazan State University by Soviet physicist Yevgeny Zavoisky in 1944, and was developed independently at the same time by Brebis Bleaney at the University of Oxford. Theory Origin of an EPR signal Every electron has a magnetic moment and spin quantum number s = \tfrac , with magnetic components m_\mathrm = + \tfrac or m_\mathrm = - \tfrac . In the presence of an external magnetic field with strength B_\mathrm , the electron's magnetic moment aligns itself either antiparallel ( m_\mathrm = - \tfrac ) or parallel ( m_\mathrm = + \tfrac ) to the fie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Buck-Goudsmit Controversy
''The'' is a grammatical article in English, denoting nouns that are already or about to be mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with nouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a consonant sound, and as (homophone of the archaic pronoun ''thee' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HIV-1
The subtypes of HIV include two main subtypes, known as HIV type 1 (HIV-1) and HIV type 2 (HIV-2). These subtypes have distinct genetic differences and are associated with different epidemiological patterns and clinical characteristics. HIV-1 exhibits a genetic relation to viruses indigenous to chimpanzees and gorillas that inhabit West Africa, while HIV-2 viruses are affiliated with viruses present in the sooty mangabey, a vulnerable West African primate. HIV-1 viruses can be further stratified into groups M, N, O, and P. Among these, HIV-1 group M viruses are the most prevalent, infecting nearly 90% of people living with HIV and are responsible for the global AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Certain subtypes are known for their increased virulence or drug resistance to different medications used to treat HIV. HIV-2 viruses are generally considered to be less virulent and less transmissible than HIV-1 M group vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Synthesis
Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In modern laboratory uses, the process is reproducible and reliable. A chemical synthesis involves one or more compounds (known as '' reagents'' or ''reactants'') that will experience a transformation under certain conditions. Various reaction types can be applied to formulate a desired product. This requires mixing the compounds in a reaction vessel, such as a chemical reactor or a simple round-bottom flask. Many reactions require some form of processing (" work-up") or purification procedure to isolate the final product. The amount produced by chemical synthesis is known as the '' reaction yield''. Typically, yields are expressed as a mass in grams (in a laboratory setting) or as a percentage of the total theoretical quantity that could be produced based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trigonal Bipyramid
A triangular bipyramid is a hexahedron with six triangular faces constructed by attaching two tetrahedra face-to-face. The same shape is also known as a triangular dipyramid or trigonal bipyramid. If these tetrahedra are regular, all faces of a triangular bipyramid are equilateral. It is an example of a deltahedron, composite polyhedron, and Johnson solid. Many polyhedra are related to the triangular bipyramid, such as similar shapes derived from different approaches and the triangular prism as its dual polyhedron. Applications of a triangular bipyramid include trigonal bipyramidal molecular geometry which describes its atom cluster, a solution of the Thomson problem, and the representation of color order systems by the eighteenth century. Special cases As a right bipyramid Like other bipyramids, a triangular bipyramid can be constructed by attaching two tetrahedra face-to-face. These tetrahedra cover their triangular base, and the resulting polyhedron has six triangles, fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
