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Hailan Hu
Hu Hailan (; born 1973) is a Chinese neuroscientist, professor, and executive director of the Center for Neuroscience at Zhejiang University School of Medicine in Hangzhou, China. Hu explores neural mechanisms underlying social behaviors and psychiatric diseases. She specifically explores the neural substrates of social rank and the role of neuron-glia interactions in driving depressive behaviors. Hu discovered the anatomical and molecular targets of ketamine's fast-acting antidepressant effects to be localized to the lateral habenular circuits in rodents. Hu was also the first scientist outside of Europe and America to be awarded the IBRO-Kemali Prize in over 20 years. She is also a member of the Jiusan Society. Early life and education Hu was born in Dongyang, Jinhua, Zhejiang province in 1973. Hu pursued her undergraduate degree at Peking University in Beijing, China. In 1996, she received her Bachelors of Science in biochemistry and molecular biology. Hu then moved to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hu (surname)
Hu (Wikt:胡, 胡) is a Chinese surname. In 2006, it was the 15th most common surname in China. In 2013, it was the 13th most common in China, with 13.7 million Chinese sharing this surname. In 2019, Hu dropped to 15th most common surname in mainland China. Some other, less common surnames pronounced Hu include Wikt:瓠, 瓠, Wikt:護, 護, Wikt:戶, 戶, Wikt:扈, 扈, Wikt:虎, 虎, Wikt:呼, 呼, Wikt:忽, 忽, Wikt:斛, 斛 and Wikt:壺, 壶. In Cantonese, “胡” is also pronounced as "Wu" or "Woo". Meaning In Classical Chinese, ''hú'' 胡 meant: "dewlap; wattle (anatomy), wattle" and was a variant Chinese character for "how; why; what" (''he'' Wikt:何, 何), "long-lasting; far-reaching" (''xia'' Wikt:遐, 遐), "part of a dagger-axe", ''hu-'' in "butterfly" (''hudie'' Wikt:蝴蝶, 蝴蝶), or possibly "Northern Barbarians". History According to tradition, the Hu (胡) surname has several historical origins. First, Hu could derive from the family of Duke Hu of Chen. Ki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jinhua
Jinhua is a prefecture-level city in central Zhejiang province in eastern China. It borders the provincial capital of Hangzhou to the northwest, Quzhou to the southwest, Lishui to the south, Taizhou, Zhejiang, Taizhou to the east, and Shaoxing to the northeast. Its population was 7,050,683 as of the 2020 census including 1,463,990 in the built-up (or metro) area made of two urban districts (not including yet the satellite city of Lanxi, Zhejiang, Lanxi, which has become essentially a suburban offshoot of Jinhua's main urban area). Jinhua is rich in Ultisols, red soil and forest resources. The Jinhua or Wu River flows through the Lan and Fuchun to the Qiantang River beside Hangzhou, which flows into Hangzhou Bay and the East China Sea. In medieval China, it formed part of the water network feeding supplies to the southern end of the Grand Canal of China, Grand Canal. It is best known for its dry-cured Jinhua ham. History and culture The history of Jinhua dates back to the 2nd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fragile X Syndrome
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder. The average IQ in males with FXS is under 55, while affected females tend to be in the borderline to normal range, typically around 70–85. Physical features may include a long and narrow face, large ears, flexible fingers, and large testicles. About a third of those affected have features of autism such as problems with social interactions and delayed speech. Hyperactivity is common, and seizures occur in about 10%. Males are usually more affected than females. This disorder and finding of fragile X syndrome has an X-linked dominant inheritance. It is typically caused by an expansion of the CGG triplet repeat within the '' FMR1'' (fragile X messenger ribonucleoprotein 1) gene on the X chromosome. This results in silencing ( methylation) of this part of the gene and a deficiency of the resultant protein (FMRP), which is required for the normal development of connections between neurons. Diagnosis req ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMPA Receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic receptor, ionotropic glutamate receptor (iGluR) and predominantly sodium ion channel that mediates fast excitatory neurotransmission in the Central nervous system, central nervous system (CNS). Its activation by the neurotransmitter Glutamate (neurotransmitter), glutamate facilitates rapid neuronal communication, essential for various brain functions, including learning and memory. Its name is derived from the ability to be activated by the artificial glutamate analog AMPA. The receptor was initially named the "Quisqualic acid, quisqualate receptor" by Watkins and colleagues after the naturally occurring agonist quisqualic acid, quisqualate. Later, the receptor was designated as the "AMPA receptor" following the development of the selective agonist AMPA by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen. The ''GRIA2''- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, San Diego
The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Established in 1960 near the pre-existing Scripps Institution of Oceanography in La Jolla, UC San Diego is the southernmost of the ten campuses of the University of California. It offers over 200 undergraduate and graduate degree programs, enrolling 33,096 undergraduate and 9,872 graduate students, with the second largest student housing capacity in the nation. The university occupies near the Pacific coast. UC San Diego consists of 12 undergraduate, graduate, and professional schools as well as 8 undergraduate residential colleges. The university operates 19 organized research units as well as 8 School of Medicine research units, 6 research centers at Scripps Institution of Oceanography, and 2 multi-campus initiatives. UC San Diego is als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Virginia
The University of Virginia (UVA) is a Public university#United States, public research university in Charlottesville, Virginia, United States. It was founded in 1819 by Thomas Jefferson and contains his The Lawn, Academical Village, a World Heritage Site, UNESCO World Heritage Site. The original governing Board of Visitors included three List of presidents of the United States, U.S. presidents: Jefferson, James Madison, and James Monroe, the latter as sitting president of the United States at the time of its foundation. As its first two Rector (academia)#United States, rectors, Presidents Jefferson and Madison played key roles in the university's foundation, with Jefferson designing both the #1800s, original courses of study and the university's #Academical Village, architecture. Located within its 1,135-acre central campus, the university is composed of eight undergraduate and three professional schools: the University of Virginia School of Law, School of Law, the University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roberto Malinow
Roberto Malinow is an Argentine-born American neuroscientist at the University of California, San Diego. He is currently a distinguished professor of neurobiology and neurosciences, and holds the Shiley Chair in Alzheimer's Disease Research at UCSD. In 2012 Dr. Malinow was elected to the National Academy of Sciences (Cellular and molecular neuroscience) and in 2015 was elected to the National Academy of Medicine. Malinow has a prolific scientific publication record, and his works have been cited over 25,000 times. For comparison, a scientist in the field of molecular biology & genetics has to receive approximately 1229 citations to be among the most cited 1% of life scientists in the world (see h-index by discipline). Further, he has contributed many ' high-impact' neuroscience articles, with an h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or schola ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julius Zhu
Julius may refer to: People * Julius (name), a masculine given name and surname (includes a list of people with the name) * Julius (nomen), the name of a Roman family (includes a list of Ancient Romans with the name) ** Julius Caesar (100–44 BC), Roman military and political leader and one of the most influential men of classical antiquity * Julius (judge royal) (fl. before 1135), noble in the Kingdom of Hungary * Julius, Count of Lippe-Biesterfeld (1812–1884), German noble * Julius, Duke of Brunswick-Lüneburg (1528–1589), German noble Arts and entertainment * Julius (''Everybody Hates Chris''), a character from the American sitcom * "Julius" (song), by Phish, 1994 Other uses * Julius (chimpanzee), a chimpanzee at Kristiansand Zoo and Amusement Park in Norway * Julius (month), the month of the ancient Roman calendar originally called ''Quintilis'' and renamed for Julius Caesar * Julius (restaurant), a tavern in Greenwich Village, New York City * Julius (software), a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTPase-activating Protein
GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are also known as RGS protein, or RGS proteins,Kimple, A.J. "Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)". ''The Journal of Biological Chemistry''. 284 (2009): 19402-19411. and these proteins are crucial in controlling the activity of G proteins. Regulation of G proteins is important because these proteins are involved in a variety of important cellular processes. The large G proteins, for example, are involved in transduction of signaling from the G protein-coupled receptor for a variety of signaling processes like hormonal signaling, and small G proteins are involved in processes like cellular trafficking and cell cycling. GAP's role in this function is to turn the G protein's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axon Guidance
Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research. Axon growth takes place from a region called the growth cone and reaching the axon target is accomplished with relatively few guidance molecules. Growth cone receptors respond to the guidance cues. Mechanisms Growing axons have a highly motile structure at the growing tip called the growth cone, which responds to signals in the extracellular environment that instruct the axon in which direction to grow. These signals, called guidance cues, can be fixed in place or diffusible; they can attract or repel axons. Growth cones contain receptors that recognize these guidance cues and interpret the signal into a chemotropic response. The general theoretical framework is that wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila
''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly. One species of ''Drosophila'' in particular, ''Drosophila melanogaster'', has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "''Drosophila''" are often used synonymously with ''D. melanogaster'' in modern biological literatur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rho Family Of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions. History Identification of the Rho family of GTPases began in the mid-1980s. The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. Rac1 and Rac2 were identified next, in 1989 followed by Cdc42 in 1990. Eight additional mammalian Rho members were identified from biological screenings until the late 1990s, a turning point in biology where availability of complete genome sequenc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
