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HMD may refer to: Science and technology * 5,10-Methenyltetrahydromethanopterin hydrogenase, an enzyme found in methanogenic archea * Heavy metal detoxification, the removal of metallic toxic substances from the body * Hepatic microvascular dysplasia, a disorder where mixing of venous blood and arterial blood in the liver occurs at the microscopic level * Hereditary mucoepithelial dysplasia, a rare autosomal dominant multiepithelial disorder * Hexamethylenediamine, an organic compound * Hoof and mouth disease, an infectious viral disease that affects cloven-hoofed animals * Hyaline membrane disease, now called infant respiratory distress syndrome * Head-mounted display, a display device, worn on the head or as part of a helmet ** Helmet-mounted display, for aviation applications * Human Mortality Database, a joint initiative of the University of California, Berkeley, US and the MPI for Demographic Research in Rostock, Germany Railway stations * Hammond station (Louisiana) (Station c ...
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5,10-Methenyltetrahydromethanopterin Hydrogenase
The 5,10-methenyltetrahydromethanopterin hydrogenase (or Hmd), the so-called iron-sulfur cluster-free hydrogenase, is an enzyme found in methanogenic archea such as '' Methanothermobacter marburgensis''. It was discovered and first characterized by the Thauer group at the Max Planck Institute in Marburg. Hydrogenases are enzymes that either reduce protons or oxidize molecular dihydrogen. Enzyme function Methanogens rely on such enzymes to catalyze the reduction of CO2 to methane. One step in methanogenesis entails conversion of a methenyl group (formic acid oxidation state) to a methylene group (formaldehyde oxidation state). Among the hydrogenase family of enzymes, Hmd is unique in that it does not directly reduce CO2 to CH4. The natural substrate of the enzyme is the organic compound methenyltetrahydrome