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Gray Laboratory
The MRC Oxford Institute for Radiation Oncology (formerly the Gray Institute for Radiation Oncology and Biology) is an institute dedicated to research on radiobiology and radiotherapy Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. It is normally delivered by a linear particle .... It is funded by the Medical Research Council (United Kingdom), Medical Research Council and is based at the University of Oxford, University of Oxford's Department of Oncology. History The institute was founded as the Gray Laboratory at Mount Vernon Hospital by Louis Harold Gray in 1953 as the world's first radiobiological institute. Early research focused on the oxygen effect to improve radio sensitivity of tumours. The institute at Mount Vernon was home to a unique 4 MeV heavy ion Van de Graaff accelerator. Research on the effects of oxygenation ...
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Mount Vernon Hospital
Mount Vernon Hospital is a hospital located in Northwood, London, Northwood in the London Borough of Hillingdon. It is one of two hospitals run by The Hillingdon Hospitals NHS Foundation Trust, the other being Hillingdon Hospital. History The hospital was founded as The North London Hospital for Consumption and Diseases of the Chest in a mansion in Hampstead High Street in 1860. A central London out-patients department opened in the Tottenham Court Road in 1861. In October 1880 Prince Arthur, Duke of Connaught and Strathearn laid the foundation stone for a purpose-built hospital at Mount Vernon in Hampstead. The hospital, which was built in the French Renaissance architecture, French Renaissance style, was completed in 1881. The adjacent Mount Vernon House, Hampstead, Mount Vernon House served as the residence of the Hospital Seceretary and from 1903 as the hospital's Nurses' Home. Meanwhile the Central London out-patients department moved from Tottenham Court Road to Fitzro ...
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University Of Oxford
The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest universities in continuous operation, second-oldest continuously operating university globally. It expanded rapidly from 1167, when Henry II of England, Henry II prohibited English students from attending the University of Paris. When disputes erupted between students and the Oxford townspeople, some Oxford academics fled northeast to Cambridge, where they established the University of Cambridge in 1209. The two English Ancient university, ancient universities share many common features and are jointly referred to as ''Oxbridge''. The University of Oxford comprises 43 constituent colleges, consisting of 36 Colleges of the University of Oxford, semi-autonomous colleges, four permanent private halls and three societies (colleges that are depar ...
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Oxford
Oxford () is a City status in the United Kingdom, cathedral city and non-metropolitan district in Oxfordshire, England, of which it is the county town. The city is home to the University of Oxford, the List of oldest universities in continuous operation, oldest university in the English-speaking world; it has buildings in every style of Architecture of England, English architecture since late History of Anglo-Saxon England, Anglo-Saxon. Oxford's industries include motor manufacturing, education, publishing, science, and information technologies. Founded in the 8th century, it was granted city status in 1542. The city is located at the confluence of the rivers Thames (locally known as the Isis) and River Cherwell, Cherwell. It had a population of in . It is north-west of London, south-east of Birmingham and north-east of Bristol. History The history of Oxford in England dates back to its original settlement in the History of Anglo-Saxon England, Saxon period. The name � ...
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The UK includes the island of Great Britain, the north-eastern part of the island of Ireland, and most of List of islands of the United Kingdom, the smaller islands within the British Isles, covering . Northern Ireland shares Republic of Ireland–United Kingdom border, a land border with the Republic of Ireland; otherwise, the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. It maintains sovereignty over the British Overseas Territories, which are located across various oceans and seas globally. The UK had an estimated population of over 68.2 million people in 2023. The capital and largest city of both England and the UK is London. The cities o ...
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Medical Research Council (United Kingdom)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a conseq ...
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Radiobiology
Radiobiology (also known as radiation biology, and uncommonly as actinobiology) is a field of clinical and basic medical sciences that involves the study of the effects of radiation on living tissue (including ionizing radiation, ionizing and non-ionizing radiation), in particular health effects of radiation. Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the radiation-induced cancer, induction of cancer with a Incubation period, latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy. Health effects In general, ionizing radiation is harmful and potentially lethal to living beings but can have health benefits in radiation therapy for the treatment of cancer an ...
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Radiotherapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body, and have not spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizin ...
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Oncology
Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's Etymology, etymological origin is the Greek word ὄγκος (''ónkos''), meaning "tumor", "volume" or "mass". Oncology is focused on the diagnosis of cancer in a person, therapy (e.g., surgery, chemotherapy, radiotherapy and other modalities), monitoring of patients after treatment, palliative care of people with advanced-stage cancers, Ethics, ethical questions surrounding cancer care, Screening (medicine), screening of patients, and the study of cancer treatments through clinical research. An oncologist typically focuses on a specialty area in cancer treatment, such as surgery, Radiation therapy, radiation, gynecology, gynecologic oncology, geriatrics, geriatric oncology, pediatrics, pediatric oncology, and various organ-specific disciplines (breast, brain, liver, among others). The exp ...
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Louis Harold Gray
Louis Harold Gray FRS (10 November 1905 – 9 July 1965) was an English physicist who worked mainly on the effects of radiation on biological systems. He was one of the earliest contributors of the field of radiobiology. Amongst many other achievements, he defined a unit of radiation dosage (absorbed dose) which was later named after him as an SI unit, the gray. Early life Gray was born as an only child on 10 November 1905 to parents Harry and Amy Gray. His father worked at a post office. Career * 1933 - Hospital physicist at Mount Vernon Hospital, London * 1936 - Developed the Bragg–Gray equation, the basis for the cavity ionization method of measuring gamma-ray energy absorption by materials * 1937 - Built an early neutron generator at Mount Vernon Hospital * 1938 - Studied biological effects of neutron The neutron is a subatomic particle, symbol or , that has no electric charge, and a mass slightly greater than that of a proton. The Discovery of the neutro ...
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Oxygen Effect
In biochemistry, the oxygen effect refers to a tendency for increased radiosensitivity of free living cells and organisms in the presence of oxygen than in Hypoxia (environmental), anoxic or hypoxic conditions, where the Blood gas tension, oxygen tension is less than 1% of atmospheric pressure (i.e., <1% of 101.3 kPa, 760 mmHg or 760 torr).


Physiology and causes


Explanation of the oxygen effect and relevance to hypoxic tissues

The oxygen effect has particular importance in external beam radiation therapy where the killing of tumour cells with photon and electron beams in well oxygenated regions can be up to three times greater than in a poorly vasculated portion of the tumour. Besides tumour hypoxia, the oxygen effect is also relevant to Hypoxia (medical), hypoxia conditions present in the normal physiology of stem cell niches such as the endosteum adjacent to bone in bone marrow and the Epithelium, epithelium layer of the Gastrointestinal ...
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Nov - 1956 Original Building Of The British Empire Cancer Campaign Research Unit In Radiobiology
Nov or NOV may refer to: * November, the 11th month of the year in the Julian and Gregorian calendars * Nav, Asalem (also , Nov or Nāv), a village in Gilan Province, Iran * Nov, Golan Heights, an Israeli moshav (a cooperative agricultural community) on the Israeli-occupied Golan Heights * Nov district, former name of Spitamen District, Sughd Province, Tajikistan * Nov, Tajikistan, a locality in Sughd Region of Tajikistan * Nov, a former name of Navkat, a town in Sughd Region of Tajikistan * Nob, Israel (also Nov), a biblical location near Jerusalem * Albano Machado Airport (IATA airport code NOV), an airport in Huambo, Angola * Novena MRT station (MRT station abbreviation NOV), a Mass Rapid Transit station in Novena, Singapore * Nation of Violence, the nickname of professional wrestler Samoa Joe * NOV Inc., an oil rig manufacturer. * NC Vouliagmeni (, ), a Greek aquatic sports club * Non obstante verdicto (also JNOV, judgment notwithstanding the verdict), a plea in a U.S. civil l ...
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Organisations Associated With The University Of Oxford
An organization or organisation (Commonwealth English; see spelling differences) is an entity—such as a company, or corporation or an institution (formal organization), or an association—comprising one or more people and having a particular purpose. Organizations may also operate secretly or illegally in the case of secret societies, criminal organizations, and resistance movements. And in some cases may have obstacles from other organizations (e.g.: MLK's organization). What makes an organization recognized by the government is either filling out incorporation or recognition in the form of either societal pressure (e.g.: Advocacy group), causing concerns (e.g.: Resistance movement) or being considered the spokesperson of a group of people subject to negotiation (e.g.: the Polisario Front being recognized as the sole representative of the Sahrawi people and forming a partially recognized state.) Compare the concept of social groups, which may include non-organiza ...
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