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Gold Effect
The Gold effect is the phenomenon in which a scientific idea, particularly in medicine, is developed to the status of an accepted position within a professional body or association by the social process itself of scientific conferences, committees, and consensus building, despite not being supported by conclusive evidence. The Gold effect is used to analyze errors in public health policy and practice, such as the widespread use of cholesterol screening in the prevention of cardiovascular disease. The effect was described by Thomas Gold in 1979. The effect was reviewed by Petr Skrabanek and James McCormick in their book ''Follies and Fallacies in Medicine''. In their book, Skrabanek and McCormick describe the Gold effect as: "At the beginning a few people arrive at a state of near belief in some idea. A meeting is held to discuss the pros and cons of the idea. More people favouring the idea than those disinterested will be present. A representative committee will be nominated to pr ...
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Gaussian Curve
In mathematics, a Gaussian function, often simply referred to as a Gaussian, is a function of the base form f(x) = \exp (-x^2) and with parametric extension f(x) = a \exp\left( -\frac \right) for arbitrary real constants , and non-zero . It is named after the mathematician Carl Friedrich Gauss. The graph of a Gaussian is a characteristic symmetric " bell curve" shape. The parameter is the height of the curve's peak, is the position of the center of the peak, and (the standard deviation, sometimes called the Gaussian RMS width) controls the width of the "bell". Gaussian functions are often used to represent the probability density function of a normally distributed random variable with expected value and variance . In this case, the Gaussian is of the form g(x) = \frac \exp\left( -\frac \frac \right). Gaussian functions are widely used in statistics to describe the normal distributions, in signal processing to define Gaussian filters, in image processing where two-dimen ...
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Scientific
Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for scientific reasoning is tens of thousands of years old. The earliest written records in the history of science come from Ancient Egypt and Mesopotamia in around 3000 to 1200 BCE. Their contributions to mathematics, astronomy, and medicine entered and shaped Greek natural philosophy of classical antiquity, whereby formal attempts were made to provide explanations of events in the physical world based on natural causes. After the fall of the Western Roman Empire, knowledge of Greek conceptions of the world deteriorated in Western Europe during the early centuries (400 to 1000 CE) of the Middle Ages, but was preserved in the Muslim world during the Islamic Golden Age and later by the efforts of Byzantine Greek scholars who br ...
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Medicine
Medicine is the science and Praxis (process), practice of caring for a patient, managing the diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, and Health promotion, promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention (medical), prevention and therapy, treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, medical genetics, genetics, and medical technology to diagnosis (medical), diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, splint (medicine), external splints and traction, medical devices, biologic medical product, biologics, and Radiation (medicine), ionizing radiation, amongst others. Medicine has been practiced since Prehistoric medicine, prehistoric times, and for most o ...
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Academic Conference
An academic conference or scientific conference (also congress, symposium, workshop, or meeting) is an event for researchers (not necessarily academics) to present and discuss their scholarly work. Together with academic or scientific journals and Preprint archives such as arXiv, conferences provide an important channel for exchange of information between researchers. Further benefits of participating in academic conferences include learning effects in terms of presentation skills and “academic habitus”, receiving feedback from peers for one’s own research, the possibility to engage in informal communication with peers about work opportunities and collaborations, and getting an overview of current research in one or more disciplines. Overview Conferences usually encompass various presentations. They tend to be short and concise, with a time span of about 10 to 30 minutes; presentations are usually followed by a . The work may be bundled in written form as academic ...
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Scientific Evidence
Scientific evidence is evidence that serves to either support or counter a scientific theory or hypothesis, although scientists also use evidence in other ways, such as when applying theories to practical problems. "Discussions about empirical evidence have tended to focus on epistemological questions regarding its role in theory testing ... even though empirical evidence also plays important and philosophically interesting roles in other areas including scientific discovery, the development of experimental tools and techniques, and the application of scientific theories to practical problems." Such evidence is expected to be empirical evidence and interpretable in accordance with scientific methods. Standards for scientific evidence vary according to the field of inquiry, but the strength of scientific evidence is generally based on the results of statistical analysis and the strength of scientific controls. Principles of inference A person's assumptions or beliefs abou ...
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Public Health Policy
Health policy can be defined as the "decisions, plans, and actions that are undertaken to achieve specific healthcare goals within a society".World Health Organization''Health Policy'' accessed 22 March 2011(Web archive)/ref> According to the World Health Organization, an explicit health policy can achieve several things: it defines a vision for the future; it outlines priorities and the expected roles of different groups; and it builds consensus and informs people. Different approaches Health policy often refers to the health-related content of a policy. Understood in this sense, there are many categories of health policies, including global health policy, public health policy, mental health policy, health care services policy, insurance policy, personal healthcare policy, pharmaceutical policy, and policies related to public health such as vaccination policy, tobacco control policy or breastfeeding promotion policy. Health policy may also cover topics related to healthcar ...
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Hypercholesterolemia
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), and dyslipidemia (any abnormalities of lipid and lipoprotein levels in the blood). Elevated levels of non-HDL cholesterol and LDL in the blood may be a consequence of diet, obesity, inherited (genetic) diseases (such as LDL receptor mutations in familial hypercholesterolemia), or the presence of other diseases such as type 2 diabetes and an underactive thyroid. Cholesterol is one of three major classes of lipids produced and used by all animal cells to form membranes. Plant cells manufacture phytosterols (similar to cholesterol), but in rather small quantities. Cholesterol is the precursor of the steroid hormones and bile acids. Since cholesterol is insoluble in water, it is transported in the blood plasma within protein par ...
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Cardiovascular Disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account ...
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Dirac Function Approximation
Distributed Research using Advanced Computing (DiRAC) is an integrated supercomputing facility used for research in particle physics, astronomy and cosmology in the United Kingdom. DiRAC makes use of multi-core processors and provides a variety of computer architectures for use by the research community. DiRAC and DiRAC II Initially DiRAC was funded with an investment of £12 million from the Government of the United Kingdom's Large Facilities Capital Fund combined with funds from the Science and Technology Facilities Council (STFC) and a consortium of universities in the UK. In 2012, the DiRAC facility was upgraded with a further £15 million of UK government capital to create DiRAC II which has five installations: # University of Cambridge HPC Service with 10000 cores and 1 Petabyte clustered file system # Cambridge Cosmos shared memory Service with 1856 cores, 14 Terabytes of globally shared memory with Intel Xeon Phi coprocessors # University of Leicester IT Services with ...
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Thomas Gold
Thomas Gold (May 22, 1920 – June 22, 2004) was an Austrian-born American astrophysicist, a professor of astronomy at Cornell University, a member of the U.S. National Academy of Sciences, and a Fellow of the Royal Society (London). Gold was one of three young Cambridge scientists who in 1948 proposed the now mostly abandoned "steady state" hypothesis of the universe. Gold's work crossed academic and scientific boundaries, into biophysics, astronomy, aerospace engineering, and geophysics. Early life Gold was born on May 22, 1920, in Vienna, Austria, to Max Gold, a wealthy Jewish industrialist (pre-war) who ran one of Austria's largest mining and metal fabrication companies, and German former actress Josefine Martin. Following the economic downfall of the European mining industry in the late 1920s, Max Gold moved his family to Berlin, where he had taken a job as director of a metal trading company.. Following the start of Nazi leader Adolf Hitler's anti-Jewish campaigns in 19 ...
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Petr Skrabanek
Petr Skrabanek (October 27, 1940 – June 21, 1994) was a doctor, physician, professor of medicine, and author of several books and many articles. Skrabanek was described by Ben Goldacre as "a lifelong champion of clear thinking, scepticism, and critical appraisal", and expressed vocal criticism of what he dubbed "cacademics", "quackupuncturists" and "nonsensus-consensus". Skrabanek was a polymath, loving jazz, history, literature, playing the piano. He spoke several languages thanks to which he was able to deeply study Joyce's last work - the avant-garde novel Finnegans Wake. Career Skrabanek studied chemistry, joining the faculty of Natural Sciences at Charles University in Prague in 1957. Following his studies he was a researcher at the Institute for Toxicology and Forensic Medicine in Prague, graduating in 1962. He also frequently contributed short articles to the Czechoslovakian science journal ''Vesmír'' (Cosmos). Beginning in 1963, Skrabanek studied medicine at the Jan ...
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Raymond Lyttleton
Raymond Arthur Lyttleton FRS (7 May 1911 – 16 May 1995) was a British mathematician and theoretical astronomer. He was born in Warley Woods near Birmingham and educated at King Edward VI Five Ways school in Birmingham, going from there to Clare College, Cambridge to read mathematics, graduating in 1933. He was elected a Fellow of St John's College in 1937 and appointed a lecturer in mathematics in the same year (until 1959). A keen amateur cricketer, he played minor counties cricket for Cambridgeshire from 1946–1949, making fifteen appearances. He was Reader in Theoretical Astronomy from 1959 to 1969, after which he was appointed to a specially created professorship in the subject. He was elected a Fellow of the Royal Society in 1955. His application citation read: "''Distinguished for his work in astronomy. Author of numerous papers on the origin and early history of the Solar System, notably his modifications of the collision theory. Showed from work of Cartan that fissi ...
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