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Gertrude Elion
Gertrude "Trudy" Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs. This new method focused on understanding the target of the drug rather than simply using trial-and-error. Her work led to the creation of the anti-retroviral drug AZT, which was the first drug widely used against AIDS. Her well known works also include the development of the first immunosuppressive drug, azathioprine, used to fight rejection in organ transplants, and the first successful antiviral drug, acyclovir (ACV), used in the treatment of herpes infection. Early life and education Elion was born in New York City on January 23, 1918, to parents Robert Elion, a Lithuanian Jewish immigrant and a dentist, and Bertha Cohen, a Polish Jewish immigrant. Her family ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive with a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global center of finance and commerce, culture, technology, entertainment and media, academics, and scientific output, the arts and fashion, and, as home to the headquarters of the United Nations, international diplomacy. With an estimated population in 2024 of 8,478,072 distributed over , the city is the most densely populated major city in the United States. New York City has more than double the population of Los Angeles, the nation's second-most populous city. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Geographic
''National Geographic'' (formerly ''The National Geographic Magazine'', sometimes branded as ''Nat Geo'') is an American monthly magazine published by National Geographic Partners. The magazine was founded in 1888 as a scholarly journal, nine months after the establishment of the society, but is now a popular magazine. In 1905, it began including pictures, a style for which it became well known. Its first color photos appeared in the 1910s. During the Cold War, the magazine committed itself to present a balanced view of the physical and human geography of countries beyond the Iron Curtain. Later, the magazine became outspoken on environmental issues. Until 2015, the magazine was completely owned and managed by the National Geographic Society. Since 2015, controlling interest has been held by National Geographic Partners. Topics of features generally concern geography, history, nature, science, and world culture. The magazine is well known for its distinctive appearance: a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phi Beta Kappa
The Phi Beta Kappa Society () is the oldest academic honor society in the United States. It was founded in 1776 at the College of William & Mary in Virginia. Phi Beta Kappa aims to promote and advocate excellence in the liberal arts and sciences, and to induct outstanding students of arts and sciences at select American colleges and universities. Since its inception, its inducted members include 17 President of the United States, United States presidents, 42 Supreme Court of the United States, United States Supreme Court justices, and 136 Nobel Prize, Nobel laureates. History Origins The Phi Beta Kappa Society had its first meeting on December 5, 1776, at the College of William & Mary in Williamsburg, Virginia by five students, with John Heath as its first President. The society established the precedent for naming American college societies after the initial letters of a secret Greek motto. The group consisted of students who frequented the Raleigh Tavern as a common meeting ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Achievement
The American Academy of Achievement, colloquially known as the Academy of Achievement, is a nonprofit educational organization that recognizes some of the highest-achieving people in diverse fields and gives them the opportunity to meet one another. The academy also brings together the leaders with promising graduate students for mentorship. It hosts an International Achievement Summit, which ends with an awards ceremony, during which new members are inducted into the academy. History Founded in 1961 by ''Sports Illustrated'' and ''LIFE'' magazine photographer Brian Reynolds, the Academy of Achievement recognizes high achievers in public service, business, science and exploration, sports, and the arts. Reynolds established the academy after realizing that the famous people he photographed from different fields did not usually get to meet one another. A 1989 ''San Francisco Chronicle'' article called the organization "little-publicized but immensely powerful". According to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walton High School (Bronx)
Walton High School was a public four-year high school located in the Jerome Park neighborhood of the Bronx in New York City. Originally an all-girl institution, Walton became co-educational in 1977. Walton, Bayside High School, Samuel J. Tilden High School, Abraham Lincoln High School, John Adams High School, Andrew Jackson High School, and Grover Cleveland High School were all built during the Great Depression from one set of blueprints, to save money. Walton's colors were sky blue and white. Its motto, ''Semper fidelis'', means 'always faithful'. The school seal was an open book supported by the torch of learning, and the school crest contains the head of Athena, Greek goddess of wisdom. The wildcat was the mascot used by the Walton's sports teams. Today the sports teams are composed of the students of each of the small mini-schools within the Walton Educational Campus. The building is in the same neighborhood as the Bronx High School of Science and DeWitt Clinton High ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lithuania
Lithuania, officially the Republic of Lithuania, is a country in the Baltic region of Europe. It is one of three Baltic states and lies on the eastern shore of the Baltic Sea, bordered by Latvia to the north, Belarus to the east and south, Poland to the south, and the Russian exclave, semi-exclave of Kaliningrad Oblast to the southwest, with a Maritime boundary, maritime border with Sweden to the west. Lithuania covers an area of , with a population of 2.89 million. Its capital and largest city is Vilnius; other major cities include Kaunas, Klaipėda, Šiauliai and Panevėžys. Lithuanians who are the titular nation and form the majority of the country's population, belong to the ethnolinguistic group of Balts and speak Lithuanian language, Lithuanian. For millennia, the southeastern shores of the Baltic Sea were inhabited by various Balts, Baltic tribes. In the 1230s, Lithuanian lands were united for the first time by Mindaugas, who formed the Kingdom of Lithuania on 6 July ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biographical Memoirs Of Fellows Of The Royal Society
The ''Biographical Memoirs of Fellows of the Royal Society'' is an academic journal on the history of science published annually by the Royal Society. It publishes obituaries of Fellows of the Royal Society. It was established in 1932 as ''Obituary Notices of Fellows of the Royal Society'' and obtained its current title in 1955, with volume numbering restarting at 1. Prior to 1932, obituaries were published in the '' Proceedings of the Royal Society''. The memoirs are a significant historical record and most include a full bibliography of works by the subjects. The memoirs are often written by a scientist of the next generation, often one of the subject's own former students, or a close colleague. In many cases the author is also a Fellow. Notable biographies published in this journal include Albert Einstein, Alan Turing, Bertrand Russell Bertrand Arthur William Russell, 3rd Earl Russell, (18 May 1872 – 2 February 1970) was a British philosopher, logician, mathematic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpes
Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes, though other forms also exist. Oral herpes involves the face or mouth. It may result in small blisters in groups, often called cold sores or fever blisters, or may just cause a sore throat. Genital herpes involves the genitalia. It may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. Herpes cycles between periods of active disease followed by periods without symptoms. The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches. Over time, episodes of active disease decrease in frequency and severity. Herpetic whitlow typically inv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acyclovir
Aciclovir, also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include the prevention of cytomegalovirus infections following transplant, and severe complications of Epstein–Barr virus infection. It can be taken by mouth, applied as a cream, or injected. Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in pregnancy with no harm having been observed. It appears to be safe during breastfeeding. Aciclovir is a nucleoside analogue that mimics guanosine. It works by decreasing the production of the virus's DNA. Aciclovir was patented in 1974, by Burroughs Wellcome, and approved for medical use in 1981. It is on the World Health Organization's List of Essential Medicines. It is av ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ Transplant
Organ transplantation is a medical procedure in which an organ (anatomy), organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a Organ donation, donor site to another location. Organ (anatomy), Organs and/or Tissue (biology), tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source. Organs that have been successfully transplanted include the Heart transplantation, heart, Kidney transplantation, kidneys, Liver transplantation, liver, Lung transplantation, lungs, Pancreas transplantation, pancreas, Intestinal transplant, intestine, Thymus transplantation, thymus and uterus transplantation, uterus. Tissues include Bone grafting, bones, tendons (both refe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azathioprine
Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. It is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus, and in kidney transplants to prevent transplant rejection, rejection. It is listed by the International Agency for Research on Cancer as a group 1 carcinogen, group 1 human carcinogen. It is taken by mouth or intravenous, injected into a vein. Common side effects include bone marrow suppression, bone-marrow suppression and vomiting. Bone-marrow suppression is especially common in people with a genetics, genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk of certain cancers. Use during pregnancy may result in harm to the baby. Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. It works via 6-thioguanine to disrupt the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
