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Genistein
Genistein (C15H10O5) is a plant-derived, aglycone isoflavone. Genistein has the highest content of all isoflavones in soybeans and soy products, such as tempeh. As a type of phytoestrogen, genistein has estrogenic activity in vitro; consequently, its long-term intake by consuming soy products may affect reproductive organs, such as the uterus and breast. It was first isolated in 1899 from the dyer's broom, ''Genista tinctoria''; hence, the chemical name. The compound structure was established in 1926, when it was found to be identical with that of prunetol. It was chemically synthesized in 1928. Genistein is a primary secondary metabolite of the ''Trifolium'' species and '' Glycine max'' (soy). Natural occurrences Isoflavones, such as genistein and daidzein, occur in soybeans and various other plants, including lupin, fava beans, kudzu, psoralea, '' Flemingia vestita'', and coffee. It is present in red clover. In soybean products Isoflavone intake from consuming soy pro ...
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Flemingia Vestita
''Flemingia vestita'', famously known as sohphlang, is a nitrogen fixing herb with characteristic tuberous root, belonging to the genus ''Flemingia''. The root is edible and is a common vegetable in some Asian tribal communities. In addition, it has been traditionally used as an anthelmintic, the basis of which is scientifically validated. It is found as a wild herb along the mountain slopes of Himalayas. It is distributed in Sichuan and Yunnan provinces of China, Nepal and Khasi hills, Jaintia Hills of Meghalaya in Northeast India. It is also sparsely found in Laos, Philippines and Vietnam. Description ''Flemingia vestita'' is a perennial herb, having a prostrate but weak stem, measuring about ~60 cm in average. It is highly branched with hairy rhizome and hirsute stems. The roots are tuberous (6 cm or longer). Leaves are pinnately compound with obovate-cuneate leaflets. Leaves are digitately 3-foliolate; and also pubescent like the stem. Lateral leaflets are obli ...
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Phytoestrogen
A phytoestrogen is a plant-derived xenoestrogen (a type of estrogen produced by organisms other than humans) not generated within the endocrine system, but consumed by eating plants or manufactured foods. Also called a "dietary estrogen", it is a diverse group of naturally occurring nonsteroidal plant compounds that, because of its structural similarity to estradiol (17-β-estradiol), have the ability to cause both estrogenic or antiestrogenic effects. Phytoestrogens are not essential nutrients because their absence from the diet does not cause a disease, nor are they known to participate in any normal biological function. Common foods containing phytoestrogens are soybeans and soy protein concentrate, miso, tempeh, and tofu. Some soy-based infant formulas manufactured with soy protein contain isoflavones. Its name comes from the Greek ''phyto'' ("plant") and ''estrogen'', the hormone which gives fertility to female mammals. The word "estrus" (Greek οίστρος) ...
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Isoflavone
Isoflavones are a type of naturally-occurring isoflavonoids, many of which act as phytoestrogens in mammals. Isoflavones occur in many plant species, but are especially high in soybeans. Although isoflavones and closely-related phytoestrogens are sold as dietary supplements, there is little scientific evidence for either the safety of long-term supplementation or of health benefits from these compounds. Some studies indicate that isoflavone supplementation may help lower the risk of hormone-related cancers. Organic chemistry and biosynthesis Isoflavone is an isomer of flavone, which is chromone substituted with a phenyl group in the 2-position. In isoflavone, the phenyl group is in the 3-position. Substituted isoflavone derivatives are related to the parent by the replacement of two or three hydrogen atoms with hydroxyl groups. Isoflavone differs from flavone (2-phenyl-4''H''-1-benzopyr-4-one) in location of the phenyl group. Isoflavones are produced via a branch of the ...
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Daidzein
Daidzein (7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one) is a naturally occurring compound found exclusively in soybeans and other legumes, and structurally belongs to a class of compounds known as isoflavones. Daidzein and other isoflavones are produced in plants through the Phenylpropanoids metabolism, phenylpropanoid pathway of secondary metabolism and are used as signal carriers, and defense responses to pathogenic attacks. Upon consumption of isoflavone-rich foods, daidzein has poor bioavailability and low water solubility. Natural occurrence Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs like kwao krua (''Pueraria mirifica'') and kudzu. It can also be found in ''Maackia amurensis'' cell cultures. Daidzein can be found in food such as mature soybeans and soy products like soy protein concentrate, tofu and textured vegetable protein. Total isoflavones in soybeans are—in general—37 percent daidzein, 57 percent ge ...
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Genista Tinctoria
''Genista tinctoria'', the dyer's greenweed or dyer's broom, is a species of flowering plant in the family Fabaceae. Its other common names include dyer's whin, waxen woad and waxen wood. The Latin specific epithet ''tinctoria'' means "used as a dye". Description It is a variable deciduous shrub growing to tall by wide, the stems woody, slightly hairy, and branched. The alternate, nearly sessile leaves are glabrous and lanceolate. Golden yellow pea-like flowers are borne in erect narrow racemes from spring to early summer. The fruit is a long, shiny pod shaped like a green bean pod. Distribution and habitat This species is native to meadows and pastures in Europe and Turkey. Properties and uses Numerous cultivars have been selected for garden use, of which 'Royal Gold' has gained the Royal Horticultural Society's Award of Garden Merit. The plant, as its Latin and common names suggest, has been used from ancient times for producing a yellow dye, which combined with woad al ...
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Soybean
The soybean, soy bean, or soya bean (''Glycine max'') is a species of legume native to East Asia, widely grown for its edible bean. Soy is a staple crop, the world's most grown legume, and an important animal feed. Soy is a key source of food, useful both for its protein and oil content. Soybean oil is widely used in cooking, as well as in industry. Traditional unfermented food uses of soybeans include edamame, as well as soy milk, from which tofu and tofu skin are made. Fermented soy foods include soy sauce, fermented bean paste, nattō, and tempeh. Fat-free (defatted) soybean meal is a significant and cheap source of protein for animal feeds and many packaged meals. For example, soybean products, such as textured vegetable protein (TVP), are ingredients in many meat and dairy substitutes. Soy based foods are traditionally associated with East Asian cuisines, and still constitute a major part of East Asian diets, but processed soy products are increasingly used ...
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Estrogen
Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. Estrogens are synthesized in all vertebrates and some insects. Quantitatively, estrogens circulate at lower levels than androgens in both men and women. While estrogen levels are significantly lower in males than in females, estrogens nevertheless have important physiological roles in males. Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many ...
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Kudzu
Kudzu (), also called Japanese arrowroot or Chinese arrowroot, is a group of climbing, coiling, and trailing deciduous perennial vines native to much of East Asia, Southeast Asia, and some Pacific islands. It is invasive species, invasive in many parts of the world, primarily North America. The vine densely climbs over other plants and trees and grows so rapidly that it smothers and kills them by blocking most of the sunlight and taking root space. The plants are in the genus ''Pueraria'', in the pea family Fabaceae, subfamily Faboideae. The name is derived from the Japanese language, Japanese name for the plant East Asian arrowroot, (''Pueraria montana'' var. ''lobata''), . Where these plants are Naturalisation (biology), naturalized, they can be invasive and are considered noxious weeds. The plant is edible, but often sprayed with herbicides. Taxonomy The name kudzu describes one or more species in the genus ''Pueraria'' that are closely related, and some of them are cons ...
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Glycine Max
The soybean, soy bean, or soya bean (''Glycine max'') is a species of legume native to East Asia, widely grown for its edible bean. Soy is a staple crop, the world's most grown legume, and an important animal feed. Soy is a key source of food, useful both for its protein and oil content. Soybean oil is widely used in cooking, as well as in industry. Traditional unfermented food uses of soybeans include edamame, as well as soy milk, from which tofu and tofu skin are made. Fermented soy foods include soy sauce, fermented bean paste, nattō, and tempeh. Fat-free (defatted) soybean meal is a significant and cheap source of protein for animal feeds and many packaged meals. For example, soybean products, such as textured vegetable protein (TVP), are ingredients in many meat and dairy substitutes. Soy based foods are traditionally associated with East Asian cuisines, and still constitute a major part of East Asian diets, but processed soy products are increasingly used in Wes ...
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Colon (anatomy)
The large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and of the digestive system in tetrapods. Water is absorbed here and the remaining waste material is stored in the rectum as feces before being removed by defecation. The colon (progressing from the ascending colon to the transverse, the descending and finally the sigmoid colon) is the longest portion of the large intestine, and the terms "large intestine" and "colon" are often used interchangeably, but most sources define the large intestine as the combination of the cecum, colon, rectum, and anal canal. Some other sources exclude the anal canal. In humans, the large intestine begins in the right iliac region of the pelvis, just at or below the waist, where it is joined to the end of the small intestine at the cecum, via the ileocecal valve. It then continues as the colon ascending the abdomen, across the width of the abdominal cavity as the transverse colon, and then desce ...
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Hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water is the nucleophile. Biological hydrolysis is the cleavage of Biomolecule, biomolecules where a water molecule is consumed to effect the separation of a larger molecule into component parts. When a carbohydrate is broken into its component sugar molecules by hydrolysis (e.g., sucrose being broken down into glucose and fructose), this is recognized as saccharification. Hydrolysis reactions can be the reverse of a condensation reaction in which two molecules join into a larger one and eject a water molecule. Thus hydrolysis adds water to break down, whereas condensation builds up by removing water. Types Usually hydrolysis is a chemical process in which a molecule of water is added to a substance. Sometimes this addition causes both the su ...
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Small Intestine
The small intestine or small bowel is an organ (anatomy), organ in the human gastrointestinal tract, gastrointestinal tract where most of the #Absorption, absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the pancreatic duct to aid in digestion. The small intestine is about long and folds many times to fit in the abdomen. Although it is longer than the large intestine, it is called the small intestine because it is narrower in diameter. The small intestine has three distinct regions – the duodenum, jejunum, and ileum. The duodenum, the shortest, is where preparation for absorption through small finger-like protrusions called intestinal villus, intestinal villi begins. The jejunum is specialized for the absorption through its lining by enterocytes: small nutrient particles which have been previously digested by enzymes in the duodenum. The main function of the ileum is to absorb vitami ...
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