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Francisco Balzarotti
Francisco Balzarotti (born in 1983 in Buenos Aires, Argentina) is an Argentinian scientist known for his work in super-resolution microscopy, particularly MINFLUX. He is a Group Leader at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria. Education From 2002 to 2007, Balzarotti studied electrical engineering at the University of Buenos Aires in Buenos Aires, Argentina. In 2012, he earned his Ph.D. in Electrical Engineering, working on research topics such as nanophotonics, optical nanolithography, superlenses, and plasmonics. Career and research For his postgraduate work, Balzarotti relocated to Germany to work as a postdoctoral researcher in the Department of NanoBiophotonics at the Max Planck Institute for Biophysical Chemistry, led by Nobel Laureate Stefan W. Hell. In Göttingen, Balzarotti played a central role in developing the super-resolution microscopy method MINFLUX which was named Breakthrough of the Year in 2017 by Physics World. The method was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buenos Aires
Buenos Aires, controlled by the government of the Autonomous City of Buenos Aires, is the Capital city, capital and largest city of Argentina. It is located on the southwest of the Río de la Plata. Buenos Aires is classified as an Alpha− global city, according to the Globalization and World Cities Research Network, GaWC 2024 ranking. The city proper has a population of 3.1 million and its urban area 16.7 million, making it the List of metropolitan areas, twentieth largest metropolitan area in the world. It is known for its preserved eclecticism, eclectic European #Architecture, architecture and rich culture, cultural life. It is a multiculturalism, multicultural city that is home to multiple ethnic and religious groups, contributing to its culture as well as to the dialect spoken in the city and in some other parts of the country. This is because since the 19th century, the city, and the country in general, has been a major recipient of millions of Immigration to Argentina, im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanophotonics
Nanophotonics or nano-optics is the study of the behavior of light on the nanometer scale, and of the interaction of nanometer-scale objects with light. It is a branch of optics, optical engineering, electrical engineering, and nanotechnology. It often involves dielectric structures such as nanoantennas, or metallic components, which can transport and focus light via surface plasmon polaritons. The term "nano-optics", just like the term "optics", usually refers to situations involving ultraviolet, visible, and near-infrared light (free-space wavelengths from 300 to 1200 nanometers). Background Normal optical components, like lenses and microscopes, generally cannot normally focus light to nanometer (deep subwavelength) scales, because of the diffraction limit ( Rayleigh criterion). Nevertheless, it is possible to squeeze light into a nanometer scale using other techniques like, for example, surface plasmons, localized surface plasmons around nanoscale metal objects, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
STED Microscopy
Stimulated emission depletion (STED) microscopy is one of the techniques that make up super-resolution microscopy. It creates super-resolution images by the selective deactivation of fluorophores, minimizing the area of illumination at the focal point, and thus enhancing the achievable resolution for a given system. It was developed by Stefan W. Hell and Jan Wichmann in 1994, and was first experimentally demonstrated by Hell and Thomas Klar in 1999. Hell was awarded the Nobel Prize in Chemistry in 2014 for its development. In 1986, V.A. Okhonin (Institute of Biophysics, USSR Academy of Sciences, Siberian Branch, Krasnoyarsk) had patented the STED idea. This patent was unknown to Hell and Wichmann in 1994. STED microscopy is one of several types of super resolution microscopy techniques that have recently been developed to bypass the diffraction limit of light microscopy to increase resolution. STED is a deterministic functional technique that exploits the non-linear response ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photoactivated Localization Microscopy
Photo-activated localization microscopy (PALM or FPALM) and stochastic optical reconstruction microscopy (STORM) are widefield (as opposed to point scanning techniques such as laser scanning confocal microscopy) fluorescence microscopy imaging methods that allow obtaining images with a resolution beyond the diffraction limit. The methods were proposed in 2006 in the wake of a general emergence of optical super-resolution microscopy methods, and were featured as Methods of the Year for 2008 by the ''Nature Methods'' journal. The development of PALM as a targeted biophysical imaging method was largely prompted by the discovery of new species and the engineering of mutants of fluorescent proteins displaying a controllable photochromism, such as photo-activatible Green fluorescent protein, GFP. However, the concomitant development of STORM, sharing the same fundamental principle, originally made use of paired cyanine dyes. One molecule of the pair (called activator), when excited near ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Information Theory
Information theory is the mathematical study of the quantification (science), quantification, Data storage, storage, and telecommunications, communication of information. The field was established and formalized by Claude Shannon in the 1940s, though early contributions were made in the 1920s through the works of Harry Nyquist and Ralph Hartley. It is at the intersection of electronic engineering, mathematics, statistics, computer science, Neuroscience, neurobiology, physics, and electrical engineering. A key measure in information theory is information entropy, entropy. Entropy quantifies the amount of uncertainty involved in the value of a random variable or the outcome of a random process. For example, identifying the outcome of a Fair coin, fair coin flip (which has two equally likely outcomes) provides less information (lower entropy, less uncertainty) than identifying the outcome from a roll of a dice, die (which has six equally likely outcomes). Some other important measu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Light Microscopy
Microscopy is the technical field of using microscopes to view subjects too small to be seen with the naked eye (objects that are not within the resolution range of the normal eye). There are three well-known branches of microscopy: optical, electron, and scanning probe microscopy, along with the emerging field of X-ray microscopy. Optical microscopy and electron microscopy involve the diffraction, reflection, or refraction of electromagnetic radiation/electron beams interacting with the specimen, and the collection of the scattered radiation or another signal in order to create an image. This process may be carried out by wide-field irradiation of the sample (for example standard light microscopy and transmission electron microscopy) or by scanning a fine beam over the sample (for example confocal laser scanning microscopy and scanning electron microscopy). Scanning probe microscopy involves the interaction of a scanning probe with the surface of the object of interest. The de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holy Grail
The Holy Grail (, , , ) is a treasure that serves as an important motif in Arthurian literature. Various traditions describe the Holy Grail as a cup, dish, or stone with miraculous healing powers, sometimes providing eternal youth or sustenance in infinite abundance, often guarded in the custody of the Fisher King and located in the hidden Grail castle. By analogy, any elusive object or goal of great significance may be perceived as a "holy grail" by those seeking such. A mysterious "grail" (Old French: ''graal'' or ''greal''), wondrous but not unequivocally holy, first appears in '' Perceval, the Story of the Grail'', an unfinished chivalric romance written by Chrétien de Troyes around 1190. Chrétien's story inspired many continuations, translators and interpreters in the later-12th and early-13th centuries, including Wolfram von Eschenbach, who portrayed the Grail as a stone in ''Parzival''. The Christian, Celtic or possibly other origins of the Arthurian grail trope are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Göttingen
Göttingen (, ; ; ) is a college town, university city in Lower Saxony, central Germany, the Capital (political), capital of Göttingen (district), the eponymous district. The River Leine runs through it. According to the 2022 German census, the population of Göttingen was 124,548. Overview The origins of Göttingen lay in a village called ''Gutingi, ''first mentioned in a document in 953 AD. The city was founded northwest of this village, between 1150 and 1200 AD, and adopted its name. In Middle Ages, medieval times the city was a member of the Hanseatic League and hence a wealthy town. Today, Göttingen is famous for its old university (''Georgia Augusta'', or University of Göttingen, "Georg-August-Universität"), which was founded in 1734 (first classes in 1737) and became the most visited university of Europe. In 1837, seven professors protested against the absolute sovereignty of the House of Hanover, kings of Kingdom of Hanover, Hanover; they lost their positions, but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stefan Hell
Stefan Walter Hell (: born 23 December 1962) is a Romanian-German physicist and one of the directors of the Max Planck Institute for Multidisciplinary Sciences in Göttingen, and of the Max Planck Institute for Medical Research in Heidelberg, both of which are in Germany. He received the Nobel Prize in Chemistry in 2014 "for the development of super-resolved fluorescence microscopy", together with Eric Betzig and William Moerner. Life Born 1962 into a Roman Catholic Banat Swabian family in Arad, Romania, he grew up at his parents' home in nearby Sântana. Hell attended primary school there between 1969 and 1977. Andreea Pocotila"Fizicianul premiat cu Nobelul pentru chimie vorbește românește și ține legătura cu mediul științific din țara noastră" ''România liberă'', October 8, 2014 Subsequently, he attended one year of secondary education at the Nikolaus Lenau High School in Timișoara before leaving with his parents to West Germany in 1978. His father was an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Nobel Laureates
The Nobel Prizes (, ) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make outstanding contributions in the fields of Nobel Prize in Chemistry, chemistry, Nobel Prize in Physics, physics, Nobel Prize in Literature, literature, Nobel Peace Prize, peace, and Nobel Prize in Physiology or Medicine, physiology or medicine. They were established by the 1895 will of Alfred Nobel, which dictates that the awards should be administered by the Nobel Foundation. An additional prize in memory of Alfred Nobel was established in 1968 by Sveriges Riksbank (Sweden's central bank) for outstanding contributions to the field of Nobel Memorial Prize in Economic Sciences, economics. Each recipient, a Nobelist or ''laureate'', receives Nobel Prize medal, a gold medal, a diploma, and a sum of money which is decided annually by the Nobel Foundation. Prize Different org ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Researcher
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. According to data from the US National Science Foundation, the number of holders of PhD in biological sciences who end up in tenure track has consistently dropped from over 50% in 1973 to less than 20% in 2006. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total population of over 84 million in an area of , making it the most populous member state of the European Union. It borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The Capital of Germany, nation's capital and List of cities in Germany by population, most populous city is Berlin and its main financial centre is Frankfurt; the largest urban area is the Ruhr. Settlement in the territory of modern Germany began in the Lower Paleolithic, with various tribes inhabiting it from the Neolithic onward, chiefly the Celts. Various Germanic peoples, Germanic tribes have inhabited the northern parts of modern Germany since classical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
