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Fox-3
NeuN (Fox-3, Rbfox3, or Hexaribonucleotide Binding Protein-3), a protein which is a homologue to the protein product of a sex-determining gene in ''Caenorhabditis elegans'', is a neuronal nuclear antigen that is commonly used as a biomarker for neurons. History NeuN was first described in 1992 by Mullen et al., who raised a series of monoclonal antibodies to mouse antigens with the original intent of finding mouse species specific immunological markers for use in transplantation experiments. In the event they isolated a hybridoma line which produced a monoclonal antibody called mAb A60, which proved to bind an antigen expressed only in neuronal nuclei and to a lesser extent the cytoplasm of neuronal cells, and which appeared to work on all vertebrates. This antigen was therefore known as NeuN for "Neuronal Nuclei" though what the A60 antibody was binding to was unknown for the next 17 years. Eventually Kim et al. used proteomic methods to show that NeuN corresponds to a protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rat Hippocampus Stained With Antibody To NeuN (green), Myelin Basic Protein (red) And DNA (blue)
Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include ''Neotoma'' (pack rats), ''Bandicota'' (bandicoot rats) and ''Dipodomys'' (kangaroo rats). Rats are typically distinguished from mice by their size. Usually the common name of a large muroid rodent will include the word "rat", while a smaller muroid's name will include "mouse". The common terms ''rat'' and ''mouse'' are not taxonomically specific. There are 56 known species of rats in the world. Species and description The best-known rat species are the black rat (''Rattus rattus'') and the brown rat (''Rattus norvegicus''). This group, generally known as the Old World rats or true rats, originated in Asia. Rats are bigger than most Old World mice, which are their relatives, but seldom weigh over in the wild. The term ''rat'' is also used in the names of other small mammals that are n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
