|
Folding Funnel
The folding funnel hypothesis is a specific version of the energy landscape theory of protein folding, which assumes that a protein's native state corresponds to its free energy minimum under the solution conditions usually encountered in cells. Although energy landscapes may be "rough", with many non-native local minima in which partially folded proteins can become trapped, the folding funnel hypothesis assumes that the native state is a deep free energy minimum with steep walls, corresponding to a single well-defined tertiary structure. The term was introduced by Ken A. Dill in a 1987 article discussing the stabilities of globular proteins. The folding funnel hypothesis is closely related to the hydrophobic collapse hypothesis, under which the driving force for protein folding is the stabilization associated with the sequestration of hydrophobic amino acid side chains in the interior of the folded protein. This allows the water solvent to maximize its entropy, lowering the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folding Funnel Schematic
Fold, folding or foldable may refer to: Arts, entertainment, and media * ''Fold'' (album), the debut release by Australian rock band Epicure * Fold (poker), in the game of poker, to discard one's hand and forfeit interest in the current pot *Above the fold and below the fold, the positioning of news items on a newspaper's front page according to perceived importance *Paper folding, or ''origami'', the art of folding paper Science, technology, and mathematics Biology *Protein folding, the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure **Folding@home, a powerful distributed-computing project for simulating protein folding *Fold coverage, quality of a DNA sequence *Skin fold, an area of skin that folds Computing *Fold (higher-order function), a type of programming operation on data structures * fold (Unix), a computer program used to wrap lines to fit in a specified width * Folding (DSP implementation), a transformat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molten Globule
In molecular biology, the term molten globule (MG) refers to protein states that are more or less compact (hence the "globule"), but are lacking the specific tight packing of amino acid residues which creates the solid state-like tertiary structure of completely folded proteins (hence the "molten"). Protein folding is navigated by a dynamic interplay of secondary and tertiary interactions. Two extreme folding pathway models have been formulated. In the first - the framework model - rapidly formed secondary structure elements assemble into a native tertiary structure. In the second - the hydrophobic collapse model - the formation of a loosely packed tertiary structure precedes secondary structure acquisition. A nucleation-condensation mechanism involving concomitant formation of short and long-range interactions combines features of both extreme models and thereby represents a unifying mechanism of protein folding. During folding, proteins span a continuum of conformers starting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acid Sequence
Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the laboratory. Protein primary structures can be directly sequenced, or inferred from DNA sequences. Formation Biological Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding along it. In biological systems, proteins are produced during translation by a cell's ribosomes. Some organisms can also make short peptides by non-ribosomal peptide synthesis, which often use amino acids other than the encoded 22, and may be cyclised, modified and cross-linked. Chemical Peptides can be synthesised chemically via a range of laboratory methods. Chemical methods typically synthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Blind Watchmaker
''The Blind Watchmaker: Why the Evidence of Evolution Reveals a Universe without Design'' is a 1986 book by Richard Dawkins, in which the author presents an explanation of, and argument for, the theory of evolution by means of natural selection. He also presents arguments to refute certain criticisms made on his first book, '' The Selfish Gene''. (Both books espouse the gene-centric view of evolution.) An unabridged audiobook edition was released in 2011, narrated by Richard Dawkins and Lalla Ward. Synopsis left, "Biomorph" that randomly evolves following changes of several numeric "genes", determining its shape; the gene values are given as bars on the top The title of the book refers to the watchmaker analogy made famous by William Paley in his 1802 book '' Natural Theology or Evidences of the Existence and Attributes of the Deity''. Paley, writing long before Charles Darwin published ''On the Origin of Species'' in 1859, held that the complexity of living organisms wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gibbs Free Energy
In thermodynamics, the Gibbs free energy (or Gibbs energy as the recommended name; symbol is a thermodynamic potential that can be used to calculate the maximum amount of Work (thermodynamics), work, other than Work (thermodynamics)#Pressure–volume work, pressure–volume work, that may be performed by a closed system, thermodynamically closed system at constant temperature and pressure. It also provides a necessary condition for processes such as chemical reactions that may occur under these conditions. The Gibbs free energy is expressed as G(p,T) = U + pV - TS = H - TS where: * U is the internal energy of the system * H is the enthalpy of the system * S is the entropy of the system * T is the temperature of the system * V is the volume of the system * p is the pressure of the system (which must be equal to that of the surroundings for mechanical equilibrium). The Gibbs free energy change (, measured in joules in International System of Units, SI) is the ''maximum'' amount of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Energy Landscape
Energy () is the quantitative property that is transferred to a body or to a physical system, recognizable in the performance of work and in the form of heat and light. Energy is a conserved quantity—the law of conservation of energy states that energy can be converted in form, but not created or destroyed. The unit of measurement for energy in the International System of Units (SI) is the joule (J). Forms of energy include the kinetic energy of a moving object, the potential energy stored by an object (for instance due to its position in a field), the elastic energy stored in a solid object, chemical energy associated with chemical reactions, the radiant energy carried by electromagnetic radiation, the internal energy contained within a thermodynamic system, and rest energy associated with an object's rest mass. These are not mutually exclusive. All living organisms constantly take in and release energy. The Earth's climate and ecosystems processes are driven pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chaperone (protein)
In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation. Chaperones are also involved in the translocation of proteins for proteolysis. The first molecular chaperones discovered were a type of assembly chaperones which assist in the assembly of nucleosomes from folded histones and DNA. One major function of molecular chaperones is to prevent the aggregation of misfolded proteins, thus many chaperone proteins are classified as heat shock proteins, as the tendency for protein aggregation is increased by heat stress. The majority of molecular chaperones do not convey any steric information for protein folding, and instead assist in protein folding by binding to and stabilizing folding intermedi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Levinthal's Paradox
Levinthal's paradox is a thought experiment in the field of computational protein structure prediction; protein folding seeks a stable energy configuration. An algorithmic search through all possible conformations to identify the minimum energy configuration (the native state) would take an immense duration; however in reality protein folding happens very quickly, even in the case of the most complex structures, suggesting that the transitions are somehow guided into a stable state through an uneven energy landscape. History In 1969, Cyrus Levinthal noted that, because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. An estimate of 10300 was made in one of his papers (often incorrectly cited as the 1968 paper). For example, a polypeptide of 100 residues will have 200 different phi and psi bond angles, two within each residue. If each of these bond angles can be in one of three st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Justin L
Justin may refer to: People and fictional characters * Justin (given name), including a list of people and fictional characters with the given name * Justin (historian), Latin historian who lived under the Roman Empire * Justin I (c. 450–527), Eastern Roman Emperor who ruled from 518 to 527 * Justin II (c. 520–578), Eastern Roman emperor who ruled from 565 to 578 * Justin (magister militum per Illyricum) (''fl.'' 538–552), Byzantine general * Justin (Moesia) (died 528), Byzantine general killed in battle * Justin (consul 540) (c. 525–566), Byzantine general * Justin Martyr (103–165), Christian martyr * Justin (gnostic), 2nd-century Gnostic Christian; sometimes confused with Justin Martyr * Justin the Confessor (died 269) * Justin of Chieti, venerated as an early bishop of Chieti, Italy * Justin of Siponto (c. 4th century), venerated as a martyr by the Catholic Church * Justin de Jacobis (1800–1860), Italian Lazarist missionary who became Vicar Apostolic of Abyssinia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Funnel
A funnel is a tube or pipe that is wide at the top and narrow at the bottom, used for guiding liquid or powder into a small opening. Funnels are usually made of stainless steel, aluminium, glass, or plastic. The material used in its construction should be sturdy enough to withstand the weight of the substance being transferred, and it should not react with the substance. For this reason, stainless steel or glass are useful in transferring diesel fuel, while plastic funnels are useful in the kitchen. Sometimes disposable paper funnels are used in cases where it would be difficult to adequately clean the funnel afterwards (for example, in adding motor oil into a car). Dropper funnels, also called dropping funnels or tap funnels, have a Tap (valve), tap to allow the controlled release of a liquid. A flat funnel, made of polypropylene, utilises living hinges and flexible walls to fold flat. The term "funnel" may refer to the Chimney (locomotive), chimney or smokestack on a steam lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Random Coil
In polymer chemistry, a random coil is a conformation of polymers where the monomer subunits are oriented randomly while still being bonded to adjacent units. It is not one specific shape, but a statistical distribution of shapes for all the chains in a population of macromolecules. The conformation's name is derived from the idea that, in the absence of specific, stabilizing interactions, a polymer backbone will "sample" all possible conformations randomly. Many unbranched, linear homopolymers — in solution, or above their melting temperatures — assume (approximate) random coils. Random walk model: The Gaussian chain There are an enormous number of different ways in which a chain can be curled around in a relatively compact shape, like an unraveling ball of twine with much open space, and comparatively few ways it can be more or less stretched out. So, if each conformation has an equal probability or statistical weight, chains are much more likely to be ball-like th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
