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Fluorexetamine
Fluorexetamine (3'-Fluoro-2-oxo-PCE, 3-FXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has reportedly been sold over the internet since around 2017, though has remained relatively uncommon. In April 2023 it was revealed by DrugsData.org that all their previously analyzed samples of fluorexetamine actually contained 2'-Fluoro-2-oxo-PCE (2-FXE, also known as CanKet) rather than 3'-Fluoro-2-oxo PCE (3-FXE). This was confirmed by a newly available reference standard for 2-FXE. Similar misidentification may have occurred in other laboratories. See also * 2-Fluorodeschloroketamine * 2F-NENDCK * 3-Fluorodeschloroketamine * 3-Fluoro-PCP * Blixeprodil * Deoxymethoxetamine * Hydroxetamine * Methoxetamine Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arylcyclohexylamine
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs. History Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not researched by the pharmaceutical industry until the 1950s. PCE was reported in 1953 and PCMo (4-(1-phenyl-cyclohexyl)-morpholine see chart below for figure) in 1954, with PCMo described as a potent sedative. Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 studies of PCP and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its analogues, as illicitly used recreational drugs due to th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-Fluorodeschloroketamine
2-Fluorodeschloroketamine (also known as 2'-Fl-2-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic related to ketamine. Its sale and use as a designer drug has been reported in various countries. It is an analogue of ketamine where the chlorine group has been replaced by fluorine. Due to its recent emergence, the pharmacological specifics of the compound are mostly unclear, but effects are reported to be similar to its parent compound, ketamine. History The synthesis of 2-FDCK was first described in a 2013 paper as part of a larger effort to synthesize and evaluate new anesthetic drugs based on ketamine and its analogues. Ketamine itself was first introduced in 1964 and was approved for clinical use in 1970. Since then it has become one of the most important and applicable general anesthetics as well as a popular recreational drug. The use of 2-FDCK as a research chemical has been reported in various countries.European Monitoring Centre for Drugs and Drug Addic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2F-NENDCK
2F-NENDCK (CanKet, 2-Fluoro-N-Ethylnordeschloroketamine, 2'-Fluoro-2-Oxo-Phenylcyclohexylethylamine, 2'-Fluoro-2-Oxo-PCE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects presumably similar to those of ketamine. Its general effects, dissociative or otherwise, may deviate from other arylcyclohexylamines. It was initially identified in Canberra, Australia in mid-August 2022 by the government-funded drug-testing service CanTEST. It has since been dubbed "CanKet" due to it originally being found in Canberra and being a structural analogue of ketamine. It has subsequently been discovered in Taiwan, China and New Zealand. Uses and Effects Uses Due to the lack of research pertaining to it, there are no known legitimate uses for CanKet. Its long-term effects on the human body are unknown, and therefore, it is generally advised for individuals to refrain from consuming CanKet, as is the case for most other designer drugs. Effects Whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Fluorodeschloroketamine
3-Fluorodeschloroketamine (3F-DCK, 3-FDCK, FXM) is a recreational designer drug related to ketamine. It is from the arylcyclohexylamine family and has dissociative effects. It was made illegal in Finland in August 2019. See also * 2-Fluorodeschloroketamine * 3-Fluoro-PCP * Blixeprodil Blixeprodil,https://iris.who.int/bitstream/handle/10665/380497/9789240107038-eng.pdf "blixeprodilum blixeprodil (2R)-2-(4-fluorophenyl)-2-(methylamino)cyclohexan-1-one N-methyl-D-aspartate (NMDA) receptor antagonist" also known by its development ... * Deschloroketamine * Fluorexetamine * Methoxmetamine References Arylcyclohexylamines Designer drugs Dissociative drugs 3-Fluorophenyl compounds Secondary amines {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Fluoro-PCP
3-Fluoro-PCP (3'-F-PCP, 3F-PCP) is a recreational designer drug from the arylcyclohexylamine family, with dissociative Dissociatives, colloquially dissos, are a subclass of hallucinogens that distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self. Although many kinds of drugs are capable of ... effects. It was first identified in Slovenia in October 2020, and was made illegal in Hungary in April 2021. See also * 3-Fluorodeschloroketamine * 3-Chloro-PCP * 3-Methyl-PCP * 3-MeO-PCP * 4-Keto-PCP * Fluorexetamine References Arylcyclohexylamines Designer drugs Dissociative drugs 1-Piperidinyl compounds 3-Fluorophenyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blixeprodil
Blixeprodil,https://iris.who.int/bitstream/handle/10665/380497/9789240107038-eng.pdf "blixeprodilum blixeprodil (2R)-2-(4-fluorophenyl)-2-(methylamino)cyclohexan-1-one N-methyl-D-aspartate (NMDA) receptor antagonist" also known by its developmental code name GM-1020 or as (''R'')-4-fluorodeschloroketamine ((''R'')-4-FDCK), is an NMDA receptor antagonist related to ketamine which is under development for the treatment of major depressive disorder, bipolar depression, and other depressive disorders. It is taken by mouth. The drug is orally active, in contrast to the poor oral bioavailability of ketamine. Its oral bioavailability is >60%. The time to peak levels of blixeprodil is 1.5hours and its elimination half-life is 4.3hours. Blixeprodil shows antidepressant-like effects in rodents. It appears to have a greater separation between antidepressant-like and ataxia-inducing doses than ketamine in rodents and hence might have better tolerability. Whereas ketamine shows only 3-fold ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deoxymethoxetamine
Deoxymethoxetamine (3'-methyl-2-oxo-PCE, DMXE, 3D-MXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is an analogue of methoxetamine where the 3-methoxy group has been replaced by methyl. It has been sold online since around October 2020, and was first definitively identified by a forensic laboratory in Denmark in February 2021. See also * 3-Methyl-PCE * 3-Methyl-PCP * 3-Methyl-PCPy * Hydroxetamine * Fluorexetamine * Methoxetamine * Methoxieticyclidine * MXiPr MXiPr (Methoxisopropamine, Isopropyloxetamine, Isopropyxetamine') is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, related to drugs such as ketamine and methoxetamine. It was first identified in ... References Arylcyclohexylamines Designer drugs Dissociative drugs Secondary amines Ketones {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydroxetamine
Hydroxetamine (3'-hydroxy-2-oxo-PCE, O-desmethylmethoxetamine, HXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is known as an active metabolite of the dissociative designer drug methoxetamine, but has also been sold in its own right since late 2019. See also * 3-HO-PCP * 4-Keto-PCP * Desmetramadol * Deoxymethoxetamine * Fluorexetamine Fluorexetamine (3'-Fluoro-2-oxo-PCE, 3-FXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has reportedly been sold over the internet since around 2017, though has remained relatively uncommon. ... References Arylcyclohexylamines Designer drugs Dissociative drugs 3-Hydroxyphenyl compounds Ketones Secondary amines {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MXiPr
MXiPr (Methoxisopropamine, Isopropyloxetamine, Isopropyxetamine') is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, related to drugs such as ketamine and methoxetamine. It was first identified in Slovenia in December 2020, and was made illegal in Hungary in April 2021. See also * 3-Methyl-PCP * Deoxymethoxetamine * Fluorexetamine * MDPCP * Methoxpropamine * O-PCE 2-Oxo-PCE (also known as ''N''-ethyldeschloroketamine, eticyclidone and O-PCE) is a dissociative drug, dissociative anesthesia, anesthetic of the arylcyclohexylamine class that is closely related to deschloroketamine and eticyclidine, and has be ... References Arylcyclohexylamines Designer drugs Dissociative drugs 3-Methoxyphenyl compounds Isopropylamino compounds {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arylcyclohexylamines
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical drug, pharmaceutical, designer drug, designer, and experimental drugs. History Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not researched by the pharmaceutical industry until the 1950s. Eticyclidine, PCE was reported in 1953 and PCMo (4-(1-phenyl-cyclohexyl)-morpholine see chart below for figure) in 1954, with PCMo described as a potent sedative. Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 studies of PCP and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its structura ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissociative
Dissociatives, colloquially dissos, are a subclass of hallucinogens that distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self. Although many kinds of drugs are capable of such an effect, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include dissociation, a general decrease in sensory experience, hallucinations, dream-like states or anesthesia. Despite most dissociatives' main mechanism of action being tied to NMDA receptor antagonism, some of these substances, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing more ''direct'' and repeatable euphoria or symptoms which are more akin to the effects of typical " hard drugs" or common drugs of abuse. This is likely why dissociatives are considered to be addictive with a fair to moderate potential for abuse, unlike psychedelics. Despite s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
