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Flagship Ventures
Flagship Pioneering is an American life sciences venture capital company based in Cambridge, Massachusetts that invests in biotechnology, life sciences, health and sustainability companies. Portfolio companies include Moderna, Indigo Agriculture, Inari Agriculture and Novomer. The firm both funds and incubates companies. History The company was founded in Cambridge in 1999 by Noubar Afeyan and Ed Kania under the name NewcoGen (short for "new company generation"), but later changed its name to Flagship Ventures, and again in 2016 to Flagship Pioneering. Several of the initial partners and executives had previously been with the venture capital firm Morgan Holland. In late 2010, Flagship formed Moderna, which focuses on drug discovery, drug development, and vaccine technologies based exclusively on messenger RNA (mRNA) technology, and which is famous for its COVID-19 vaccine. In 2013, Flagship helped fund the creation of Editas Medicine to use CRISPR gene editing for the deve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Private Company
A privately held company (or simply a private company) is a company whose Stock, shares and related rights or obligations are not offered for public subscription or publicly negotiated in their respective listed markets. Instead, the Private equity, company's stock is offered, owned, traded or exchanged privately, also known as "over-the-counter (finance), over-the-counter". Related terms are unlisted organisation, unquoted company and private equity. Private companies are often less well-known than their public company, publicly traded counterparts but still have major importance in the world's economy. For example, in 2008, the 441 list of largest private non-governmental companies by revenue, largest private companies in the United States accounted for $1.8 trillion in revenues and employed 6.2 million people, according to ''Forbes''. In general, all companies that are not owned by the government are classified as private enterprises. This definition encompasses both publ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moderna COVID-19 Vaccine
The Moderna COVID19 vaccine, sold under the brand name Spikevax, is a COVID-19 vaccine developed by the American company Moderna, the United States National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA). Depending on the jurisdiction, it is authorized for use in humans aged six months, twelve years, or eighteen years and older. It provides protection against COVID-19, which is caused by infection by the Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 virus. It is designed to be administered in two or three 0.5-Litre#SI prefixes applied to the litre, mL doses given by intramuscular injection, primarily into the deltoid muscle, at an interval of at least 28 days apart. The World Health Organization advises an eight-week interval between doses to optimize efficacy. Additional booster doses are approved in some regions to maintain immunity. Clinical trials and real-world data have demonst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polaris Partners
Polaris Partners is a venture capital firm active in the field of healthcare and biotechnology companies. The company has offices in Boston, Massachusetts, New York, New York and San Francisco, California. History Polaris Partners was founded in 1996 by Jon Flint, Terry McGuire, Steve Arnold. The firm has over $5 billion in committed capital and is now making investments through its tenth fund. The current managing partners are Amy Schulman, and Brian Chee. Polaris Partners also has two affiliate funds. Polaris Growth Fund targets investments in profitable, founder-owned technology companies and is led by managing partners Bryce Youngren and Dan Lombard. Polaris Innovation Fund focuses on the commercial and therapeutic potential of early-stage academic research and is led by managing partners Amy Schulman and Ellie McGuire. See also Polaris Growth FundPolaris Innovation Fund References * Gupta, Udayan.Done Deals: Venture Capitalists Tell Their Stories 2000 * ttps://we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Enterprise Associates
New Enterprise Associates (NEA) is an American-based venture capital firm. NEA focuses investment stages ranging from seed stage through growth stage across an array of industry sectors. With over $25 billion in committed capital, NEA is one of the world's largest venture capital firms.NEA - History (Company Website)New Enterprise Associates Closes $2.6 Billion In One Of Largest Venture Funds Ever Forbes, July, 2012 History NEA was founded in 1977 by C. Richard Kramlich, C. Richar ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simon & Schuster
Simon & Schuster LLC (, ) is an American publishing house owned by Kohlberg Kravis Roberts since 2023. It was founded in New York City in 1924, by Richard L. Simon and M. Lincoln Schuster. Along with Penguin Random House, Hachette Book Group USA, Hachette, HarperCollins and Macmillan Publishers, Simon & Schuster is considered one of the Big Five (publishers), 'Big Five' English language publishers. , Simon & Schuster was the third largest publisher in the United States, publishing 2,000 titles annually under 35 different Imprint (trade name), imprints. History Early years In 1924, Richard L. Simon, Richard Simon's aunt, a crossword puzzle enthusiast, asked whether there was a book of ''New York World'' crossword puzzles, which were popular at the time. After discovering that none had been published, Simon and M. Lincoln Schuster, Max Schuster decided to launch a company to exploit the opportunity.Frederick Lewis Allen, ''Only Yesterday: An Informal History of the 1920s'', p. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Code Breaker
''The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race'' is a non-fiction book authored by American historian and journalist Walter Isaacson. Published in March 2021 by Simon & Schuster, it is a biography of Jennifer Doudna, the winner of the 2020 Nobel Prize in Chemistry for her work on the CRISPR system of gene editing. Promotion On March 22, 2021, Isaacson appeared on ''The Late Show with Stephen Colbert'' to discuss the book. Reception The book debuted at number one on ''The New York Times'' nonfiction best-seller list for the week ending March 13, 2021. In its starred review, ''Kirkus Reviews'' called it a "vital book about the next big thing in science—and yet another top-notch biography from Isaacson." ''Publishers Weekly'' called it a "gripping account of a great scientific advancement and of the dedicated scientists who realized it." References External linksThe Code Breakerat the Simon & Schuster websiteCRISPR Scientist's Biograph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Chemistry
The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation and awarded by the Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry, which consists of five members elected by the Academy. The award is presented in Stockholm at an annual ceremony on December 10th, the anniversary of Nobel's death. The first Nobel Prize in Chemistry was awarded in 1901 to Jacobus Henricus van 't Hoff, of the Netherlands, "for his discovery of the laws of chemical dynamics and osmotic pressure in solutions". From 1901 to 2024, the award has been bestowed on a total of 195 individuals. The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David R
David (; , "beloved one") was a king of ancient Israel and Judah and the Kings of Israel and Judah, third king of the Kingdom of Israel (united monarchy), United Monarchy, according to the Hebrew Bible and Old Testament. The Tel Dan stele, an Canaanite and Aramaic inscriptions, Aramaic-inscribed stone erected by a king of Aram-Damascus in the late 9th/early 8th centuries BCE to commemorate a victory over two enemy kings, contains the phrase (), which is translated as "Davidic line, House of David" by most scholars. The Mesha Stele, erected by King Mesha of Moab in the 9th century BCE, may also refer to the "House of David", although this is disputed. According to Jewish works such as the ''Seder Olam Rabbah'', ''Seder Olam Zutta'', and ''Sefer ha-Qabbalah'' (all written over a thousand years later), David ascended the throne as the king of Judah in 885 BCE. Apart from this, all that is known of David comes from biblical literature, Historicity of the Bible, the historicit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Church (geneticist)
George McDonald Church (born August 28, 1954) is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. Through his Harvard laboratory, Church has co-founded around 50 biotechnology companies. In 2018, the Church laboratory at Harvard spun off 16 biotechnology companies in one year. The Church laboratory works on research projects that are distributed in diverse areas of modern biology like developmental biology, neurobiology, information processing, medical genetics, aging, genomics, gene therapy, diagnostics, chemistry & bioengineering, space biology & space genetics, and ecosystem. Research and technology development ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jennifer Doudna
Jennifer Anne Doudna (; born February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka-shing, Li Ka Shing Chancellor, Chancellor's Professor, Chair Professor in the department of chemistry and the department of molecular and cell biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997. In 2012, Doudna and Emmanuelle Charpentier were the first to propose that CRISPR-Cas9 (enzymes from bacteria that control microbial immunity) could be used for programmable editing of genomes, which has been called one of the most significant discoveries in the history of biology. Since then, Doudna has been a leading figure in what is referred to as the "CRISPR revolution" ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feng Zhang
Feng Zhang (; born October 22, 1981) is a Chinese-born American biochemist. Zhang currently holds the James and Patricia Poitras Professorship in Neuroscience at the McGovern Institute for Brain Research and in the Departments of Brain and Cognitive Sciences and Biological Engineering at the Massachusetts Institute of Technology. He also has appointments with the Broad Institute of MIT and Harvard (where he is a core member). He is most well known for his role in the development of optogenetics and CRISPR technologies. Early life and education Zhang was born in China in 1981, where both his parents were computer programmers. At age 11, he moved to Iowa with his mother. He attended Theodore Roosevelt High School and Central Academy in Des Moines, graduating in 2000. He earned his B.A. in chemistry and physics in 2004 from Harvard University, where he worked with Xiaowei Zhuang. He then received his PhD in chemical and biological engineering from Stanford University in 2009 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 dalton (unit), kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR gene editing, CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
