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FT-104
RE104, formerly known as FT-104, and as 4-glutaryloxy-''N'',''N''-diisopropyltryptamine (4-HO-DiPT ''O''-glutarate or 4-GO-DiPT), is an investigational drug product being developed by the pharmaceutical company Reunion Neuroscience. RE104 a prodrug ester of a synthetic psychedelic 4-hydroxytryptamine, 4-HO-DiPT. It is one of a number of related psychedelic derivatives being developed as pharmaceuticals to treat mood disorders. RE104 is in human clinical trials as a possible treatment for postpartum depression and treatment-resistant depression. As of 2024, RE104 entered a Phase II clinical trial for post-partum depression. Pharmacology RE104 is a prodrug that is converted into the psychedelic tryptamine 4-HO-DiPT upon administration. 4-OH-DiPT s chemically related to the neurotransmitter serotonin and acts as a non-selective agonist of the serotonin receptors. 4-OH-DiPT acts as an agonist on the serotonin 2A receptor (Ki 120 nM). Activation of one serotonin receptor, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-HO-DiPT
4-HO-DiPT, also known as 4-hydroxy-''N'',''N''-diisopropyltryptamine or as iprocin, is a synthetic compound, synthetic psychedelic drug of the substituted tryptamine, tryptamine family. It is a higher homologous series, homologue of psilocin and 4-HO-DET and is a positional isomer of 4-HO-DPT. Use and dosage In ''TiHKAL'', Alexander Shulgin reported that 4-HO-DiPT had a dose range of 15 to 20mg oral administration, orally and a duration of action, duration of 2 to 3hours. However, a wider recreational drug, recreational dose range of 3 to 30mg or more orally has also been reported. The drug is active at around 3mg and above, and its effects last for 2 to 3hours. Shulgin has stated that 4-HO-DiPT has an especially steep dose–response curve and narrow dose range, with doses below 10mg having few to no effects and there having been no trials above 20mg due to the intensity of its effects. Effects The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psych ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
