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FAEFHI
FAEFHI, also known as 4-(2-aminoethyl)-5-hydroxyindole, is a serotonin receptor modulator of the indole group related to serotonin and other substituted tryptamine, tryptamines. It is a positional isomer of serotonin in which the ethyl group, ethylamine side chain at the 3 position of the indole ring system (chemistry), ring system has been moved to the 4 position. FAEFHI can also be thought of as a greatly simplified structural analog, analogue of LSD and hence partial ergoline. Although FAEFHI shows significant affinity (pharmacology), affinity for serotonin receptors, it had much lower affinity than serotonin or tryptamine (171-fold lower than serotonin and 5-fold lower than tryptamine). In addition, it did not show serotonin-like activity (i.e., serotonin receptor agonism) even at very high concentrations ''in vitro''. FAEFHI was first described in the scientific literature by 1984. See also * Partial ergoline * FHATHBIN * RU-27251 * DEIMDHPCA * WXVL_BT0793LQ2118 References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FHATHBIN
FHATHBIN, also known as 5-hydroxy-11-aminotetrahydrobenzindole, is a serotonin receptor agonist of the partial ergoline group.\ It is a cyclized tryptamine and tricyclic compound, tricyclic chemical derivative, derivative of serotonin (5-hydroxytryptamine) as well as a simplified structural analog, analogue of LSD. The drug is known to act on the serotonin 5-HT1A receptor, 5-HT1A receptor. FHATHBIN was first reported in the scientific literature by 1984. See also * Partial ergoline * RU-27849 * Bay R 1531 (LY-197206) * FAEFHI * O-Methylnordehydrobufotenine, ''O''-Methylnordehydrobufotenine References 5-Hydroxytryptamines Alpha-Alkyltryptamines Partial ergolines Phenethylamines Serotonin receptor agonists Tricyclic compounds {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergolines
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ... and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergoline
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-27251
RU-27251, also known as 3,5-secoergoline or as 4-piperidin-3-yl-1''H''-indole, is a serotonin receptor modulator and dopamine receptor agonist of the partial ergoline family. Its affinity (KD) for the dopamine D2high receptor was 72nM and for the dopamine D2low receptor was 11,600nM. RU-27251 was first described in the scientific literature by 1983. See also * Partial ergoline * Secoergoline * Seco-LSD * FAEFHI * DEIMDHPCA * WXVL_BT0793LQ2118 DEIMDHPCA, also known as 3,5-seco-LSD, is an indole derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the analogue of LS ... References Dopamine agonists Indoles Partial ergolines Piperidines Serotonin receptor modulators {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indoles
Indole is an organic compound with the formula . Indole is classified as an aromatic Heterocyclic compound, heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole where one or more of the hydrogen atoms have been replaced by substituent groups. Indoles are widely distributed in nature, most notably as amino acid tryptophan and neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. It has been identified in cannabis. It is the main volatile compound in stinky tofu. When indole is a substituent on a larger molecule, it is called an ''indolyl group'' by systematic nomenclature. Indole undergoes electrophilic substitution, mainly at position ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethyl Compounds
Ethyl may refer to: Arts and entertainment *Ethyl Sinclair, a character in the ''Dinosaurs'' television show Science and technology * Ethyl group, an organic chemistry moiety * Ethyl alcohol (or ethanol) * Ethyl Corporation, a fuel additive company ** Tetraethyllead Tetraethyllead (commonly styled tetraethyl lead), abbreviated TEL, is an organolead compound with the formula lead, Pb(ethyl group, C2H5)4. It was widely used as a fuel additive for much of the 20th century, first being mixed with gasoline begi ...-treated gasoline See also * Ethel (other) {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amines
In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of electrons. Amines can also exist as hetero cyclic compounds. Aniline is the simplest aromatic amine, consisting of a benzene ring bonded to an amino group. Amines are classified into three types: primary (1°), secondary (2°), and tertiary (3°) amines. Primary amines (1°) contain one alkyl or aryl substituent and have the general formula RNH2. Secondary amines (2°) have two alkyl or aryl groups attached to the nitrogen atom, with the general formula R2NH. Tertiary amines (3°) contain three substituent groups bonded to the nitrogen atom, and are represented by the formula R3N. The functional group present in primary amines is called the amino group. Classification of amines Amines can be classified according to the nature and number o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WXVL BT0793LQ2118
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid indolic phenethylamine-containing compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A and 5-HT2C receptor agonist ''in vitro''. Its affinities () are in the ranges of 10–100nM for the serotonin 5-HT2A receptor and 100–1,000nM for the serotonin 5-HT2C receptor, while its activational potencies () are less than 10nM for the serotonin 5-HT2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEIMDHPCA
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the structural analogue, analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system (chemistry), ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid structure, rigid indole, indolic substituted phenethylamine, phenethylamine-containing chemical compound, compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor, 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C receptor agonist ''in vitro''. Its affinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical contributions. These papers serve as essential sources of knowledge and are commonly referred to simply as "the literature" within specific research fields. The process of academic publishing involves disseminating research findings to a wider audience. Researchers submit their work to reputable journals or conferences, where it undergoes rigorous evaluation by experts in the field. This evaluation, known as peer review, ensures the quality, validity, and reliability of the research before it becomes part of the scientific literature. Peer-reviewed publications contribute significantly to advancing our understanding of the world and shaping future research endeavors. Original scientific research first published in scientific journals co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, known as clinical trials, and whole plants. Definition ''In vitro'' (Latin language, Latin for "in glass"; often not italicized in English usage) studies are conducted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
