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ExPEC4V
ExPEC4V, also known as JNJ-63871860, is a vaccine against urinary tract infections (UTIs) and ''Escherichia coli'' infection. It is an ''Escherichia coli'' polysaccharide conjugate vaccine. The vaccine is administered by intramuscular injection. It is being developed by GlycoVaxyn and Johnson & Johnson. As of November 2023, ExPEC4V is in phase 2 clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...s. There is also a 10-valent form called ExPEC10V (VAC-52416; JNJ-69968054). In February 2025 Johnson & Johnson stopped the Phase III trial of ExPEC after interim results found it failed to demonstrate efficacy over placebo. See also * UTI vaccine References {{Portal bar, Medicine Experimental urogynecological drugs Vaccines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UTI Vaccine
A UTI vaccine is a vaccine used for prevention of recurrent urinary tract infections (UTIs). A number of UTI vaccines have been developed and/or marketed. These include Uromune (MV-140; sublingual spray), UroVaxom (OM-89, OM-8980; oral tablet), Solco-Urovac (Strovac; vaginal suppository or intramuscular injection), ExPEC4V (V10, JNJ-63871860; intramuscular injection), and SEQ-400 (route unspecified). Background Recurrent UTIs are common in women, causing significant physical and emotional distress. While antibiotics are widely used to treat them, the recurrence of UTIs poses a significant challenge. Long-term antibiotic use not only poses health risks but also contributes to the growing problem of antibiotic resistance, making effective treatment more challenging. Uromune (MV-140) Uromune (developmental code name MV-140) is a vaccine developed to treat recurrent UTIs that is made from heat-inactivated bacteria mixed with in glycerol, sodium chloride, artificial pineapple f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |