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Evelyn Maisel Witkin
Evelyn M. Witkin ( Maisel; March 9, 1921 – July 8, 2023) was an American bacterial geneticist at Cold Spring Harbor Laboratory (1944–1955), SUNY Downstate Medical Center (1955–1971), and Rutgers University (1971–1991). Witkin was considered innovative and inspirational as a scientist, teacher and mentor. Her work on DNA damage and DNA repair in bacteria is foundational to our understanding of such processes in living organisms. Her work has direct application to the effects of aging and to the diagnosis and treatment of human diseases such as cancer. Witkin was awarded the National Medal of Science in 2002 for her pioneering work on DNA mutagenesis and DNA repair. In 2015, Witkin received the Albert Lasker Award for Basic Medical Research "for discoveries concerning the DNA-damage response - a fundamental mechanism that protects the genomes of all living organisms." Career Witkin grew up in Queens, New York. She commuted to attend high school in Manhattan at Washingto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive with a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global center of finance and commerce, culture, technology, entertainment and media, academics, and scientific output, the arts and fashion, and, as home to the headquarters of the United Nations, international diplomacy. With an estimated population in 2024 of 8,478,072 distributed over , the city is the most densely populated major city in the United States. New York City has more than double the population of Los Angeles, the nation's second-most populous city. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washington Irving Campus
The Washington Irving Campus is a public school building located at 40 Irving Place between East 16th and 17th Streets in the Gramercy Park neighborhood of Manhattan, New York City, near Union Square. Operating as the Washington Irving High School until 2008, it now houses six schools under the New York City Department of Education. The constituent schools include the Gramercy Arts High School, the High School for Language and Diplomacy, the International High School at Union Square, the Union Square Academy for Health Sciences, the Academy for Software Engineering, and the Success Academy Charter School. History Washington Irving High School The school was founded as an all-girls school due in large part to the efforts of Patrick F. McGowan, then head of the Board of Education and later acting mayor of New York City. The school is named after the writer Washington Irving. The building in which the school is located was designed by the architect C.B.J. Snyder ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evelyn M
Evelyn may refer to: Places Australia * Evelyn County, New South Wales, a cadastral division * Electoral district of Evelyn, an electoral district in Victoria * Evelyn, Queensland, a locality in the Tablelands Region Canada * Evelyn, Ontario United Kingdom *Evelyn, London * Evelyn Gardens, a garden square in London United States * Evelyn, Michigan * Evelyn, Texas * Evelyn, Wirt County, West Virginia * Evelyn (VTA), former light rail train station in Mountain View, California Schools * Evelyn College for Women, or Evelyn College, the former women's college of Princeton University * Evelyn High School, in Bulawayo, Zimbabwe Entertainment * ''Evelyn'' (2002 film), a film starring Sophie Vavasseur and Pierce Brosnan * ''Evelyn'' (2018 film), a documentary * '' Evelyn: The Cutest Evil Dead Girl'', 2002 short film and black comedy directed by Brad Peyton * ''Evelyn'' (play), a 1969 radio play by Rhys Adrian * ''Evelyn'' (EP), an EP by The Mess Hall * "Evelyn", ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SOS Response
The SOS response is a global transcriptional response to DNA damage in prokaryotes, in which the cell cycle is arrested and DNA repair mechanisms (error-free as well as error-prone) are induced. The regulation of this response is driven by two proteins, RecA and LexA. The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor ( LexA) of SOS response genes thereby inducing the response. It is an error-prone repair system that contributes significantly to DNA changes observed in a wide range of bacterial species. Discovery The SOS response was articulated by Evelyn Witkin. Later, by characterizing the phenotypes of mutagenised ''E. coli'', she and post doctoral student Miroslav Radman detailed the SOS response to UV radiation in bacteria. The SOS response to DNA damage was a seminal discovery because it was the first coordinated stress response to be elucidated. Mechanism During normal growth, the SOS genes are under the repressor of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Free University Of Brussels (1834–1969)
The Free University of Brussels ( or ULB; , later ''Vrije Universiteit Brussel'') was a private university in Brussels, Belgium. It existed between 1834 and 1969 when it split along linguistic lines. Founded in 1834 on the principle of "free inquiry" (), its founders envisaged the institution as a freethought, freethinker reaction to the traditional dominance of Catholicism in the country's education system. It was avowedly secularism, secular and particularly associated with Liberalism in Belgium, political liberalism during the era of pillarisation. The Free University was one of Belgium's major universities, together with the Catholic University of Leuven (1835–1968), Catholic University of Leuven and the University of Liège, state universities of Liège and University of Ghent, Ghent. The "Linguistic Wars" affected the Free University, which split along language lines in 1969 in the aftermath of Split of the Catholic University of Leuven, student unrest at Leuven the prev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miroslav Radman
Miroslav Radman (born April 30, 1944) is a Croatian biologist. Biography Radman was born in Split, PR Croatia, Yugoslavia. From 1962–1967 he studied experimental biology, physical chemistry and molecular biology at the University of Zagreb and in 1969 he obtained a doctorate degree in molecular biology at the Free University of Brussels. He spent the next three years at Harvard University as a postdoctoral researcher. From 1973 until 1983 he was Professor of Molecular Biology at the Free University of Brussels and from 1983 until 1998 the Research Director at the French Centre for Scientific Research at the University of Paris 7. He is now a professor of cellular biology at the Faculté de Médecine – Necker, Université Paris V, Paris, France. In 2002 he became a full member of the French Academy of Sciences, the first Croat to do so in the Academy's history. Radman is a co-founder of the Mediterranean Institute For Life Sciences located in Split, Croatia. Scientific wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mutation Frequency Decline
Mutation Frequency Decline (''mfd'') is the gene which encodes the protein Mfd (also known as Transcription Repair Coupling Factor, TRCF). Mfd functions in transcription-coupled repair to remove a stalled RNA polymerase that has encountered DNA damage and is unable to continue translocating. The protein is named after the fact that it reduces the chances of suppressor mutations in UV-irradiated cells (or rather, knockout cells show higher rates of such mutations). It does not reduce the chance of every kind of mutation. In fact, it seems to increase the chances of mutation in general, helping to evolve new traits such as antimicrobial resistance. Molecular function Mfd utilizes ATP to translocate along DNA, most likely forcing RNA polymerase forward and ultimately dissociating it from the DNA template. Mfd also contains binding domains which recruit UvrA and trigger the associated nucleotide excision repair pathway and was initially discovered when its mutation led to a decr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Excision Repair
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. Intercalation (biochemistry), intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize Base excision repair#Lesions processed by BER, specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by Base excision repair#DNA glycosylases, specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ultraviolet Light
Ultraviolet radiation, also known as simply UV, is electromagnetic radiation of wavelengths of 10–400 nanometers, shorter than that of visible light, but longer than X-rays. UV radiation is present in sunlight and constitutes about 10% of the total electromagnetic radiation output from the Sun. It is also produced by electric arcs, Cherenkov radiation, and specialized lights, such as mercury-vapor lamps, tanning lamps, and black lights. The photons of ultraviolet have greater energy than those of visible light, from about 3.1 to 12 electron volts, around the minimum energy required to ionize atoms. Although long-wavelength ultraviolet is not considered an ionizing radiation because its photons lack sufficient energy, it can induce chemical reactions and cause many substances to glow or fluoresce. Many practical applications, including chemical and biological effects, are derived from the way that UV radiation can interact with organic molecules. These int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbara McClintock
Barbara McClintock (June 16, 1902 – September 2, 1992) was an American scientist and cytogenetics, cytogeneticist who was awarded the 1983 Nobel Prize in Physiology or Medicine. McClintock received her PhD in botany from Cornell University in 1927. There she started her career as the leader of the development of maize cytogenetics, the focus of her research for the rest of her life. From the late 1920s, McClintock studied chromosomes and how they change during reproduction in maize. She developed the technique for visualizing maize chromosomes and used microscopic analysis to demonstrate many fundamental genetic ideas. One of those ideas was the notion of genetic recombination by chromosomal crossover, crossing-over during meiosis—a mechanism by which chromosomes exchange information. She is often credited with producing the first genetic linkage, genetic map for maize, linking regions of the chromosome to physical traits. However this legend has been corrected by Kass (202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bernard Davis (biologist)
Bernard David Davis (January 7, 1916 – January 14, 1994) was an American biologist who made major contributions in microbial physiology and metabolism. Davis was a prominent figure at Harvard Medical School in microbiology and in national science policy. He was the 1989 recipient of the Selman A. Waksman Award in Microbiology from the National Academy of Sciences. Education Davis was born in Franklin, Massachusetts, where his parents, Jewish immigrants from Lithuania, had settled. He was valedictorian at his high school, then attended Harvard University, where he majored in biochemistry. After earning his Bachelor of Science degree, he enrolled at Harvard Medical School, graduating in 1940 with a rare M.D., summa cum laude. He was elected a Fellow of the American Academy of Arts and Sciences in 1958. In a front-note to a posthumously published commentary that appeared in 2000, the major contributions of Davis to microbial physiology has been noted as, "the use of penicilli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leo Szilard
Leo Szilard (; ; born Leó Spitz; February 11, 1898 – May 30, 1964) was a Hungarian-born physicist, biologist and inventor who made numerous important discoveries in nuclear physics and the biological sciences. He conceived the nuclear chain reaction in 1933, and patented the idea in 1936. In late 1939 he wrote the letter for Albert Einstein's signature that resulted in the Manhattan Project that built the atomic bomb, and then in 1945 wrote the Szilard petition asking president Harry S. Truman to demonstrate the bomb without dropping it on civilians. According to György Marx, he was one of the Hungarian scientists known as The Martians. Szilard initially attended Palatine Joseph Technical University in Budapest, but his engineering studies were interrupted by service in the Austro-Hungarian Army during World War I. He left Hungary for Germany in 1919, enrolling at Technische Hochschule (Institute of Technology) in Berlin-Charlottenburg (now Technische Universität ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
