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Europhenome
Europhenome is a resource for presenting, searching and analysing mouse phenotypes that were revealed by high throughput mouse phenotyping programmes such as EUMODIC. The EuroPhenome project provides access to raw and annotated mouse phenotyping data generated from primary pipelines such as EMPReSSlim and secondary procedures from specialist centres. Mutants of interest can be identified by searching the gene or the predicted phenotype. Description EuroPhenome is an open source project to develop a software system for capturing, storing, and analysing raw phenotyping data from standard operating procedures contained in EMPReSS. EuroPhenome is primarily based in the bioinformatics group at MRC Harwell. The development of EuroPhenome is in collaboration with the Helmholtz Zentrum München, the Wellcome Trust Sanger Institute, and the Clinique de la Souris (France). Initially, EuroPhenome was developed within the EUMORPHIA (European Union Mouse Research for Public Health and In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Mouse Phenotyping Consortium
The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. Launched in September 2011, the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions. The initiative is projected to take 10 years (until 2021), and will focus on analysing homozygous mutant mice generated on an isogenic C57BL/6N background by the International Knockout Mouse Consortium. The mouse strains are characterized in a broad based phenotyping pipeline that is focused on revealing insights into human disease by measuring embryonic, neuromuscular, sensory, cardiovascular, metabolic, respiratory, haematological, and neurological parameters. The protocols used to assess these phenotypes have been standardized across the IMPC partners and are available at IMPReSS. Mouse strains generated by the IM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Standard Operating Procedure
A standard operating procedure (SOP) is a set of step-by-step instructions compiled by an organization to help workers carry out routine operations. SOPs aim to achieve efficiency, quality output, and uniformity of performance, while reducing miscommunication and failure to comply with industry regulations. Some military services (e.g., in the U.S. and the UK) use the term standing (rather than ''standard'') operating procedure, since a military SOP refers to a unit's unique procedures, which are not necessarily standard to another unit. The word "standard" could suggest that only one (standard) procedure is to be used across all units. The term is sometimes used facetiously to refer to practices that are unconstructive, yet the norm. In the Philippines, for instance, "SOP" is the term for pervasive corruption within the government and its institutions. Clinical research and practice In clinical research, the '' International Council for Harmonisation'' (ICH) defines SOPs as "d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRC Harwell
MRC may refer to Government * Medical Research Council (United Kingdom) * Medical Reserve Corps, a US network of volunteer organizations * Municipalité régionale de comté (regional county municipality), Quebec, Canada * Military Revolutionary Committee, in revolutionary Russia * Virginia Marine Resources Commission * Mail recovery center, or postal dead letter office * The Mississippi River Commission Organizations * Malaysian Red Crescent Society, a humanitarian organisation * Media Research Center, a US organization * Media Rating Council, a US organization * Medicare Rights Center, a US nonprofit organization * Migrant Resource Centre, an Australian organisation Politics * Mombasa Republican Council, a Kenyan separatist organization * Movement for the Rehabilitation of Citizens–Rurenzangemero, a Burundi political party * Mouvement républicain et citoyen (Citizen and Republican Movement), a French political party * Mouvement Révolutionnaire Congolais (Congolese Rev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helmholtz Zentrum München
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), also known as Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres. It was founded in 1960 and is a joint venture by the Federal Ministry of Education and Research and Bavarian State Ministry of Finance and Home. Mission The mission of Helmholtz Munich is to find new personalized medical solutions for the prevention, diagnosis and therapy of environmentally triggered diseases to promote a healthier society in a rapidly changing world. Management Prof. Dr. H. Matthias Tschöp has been the Scientific Director and Chief Executive Officer of the Center since 2018. In 2019 Kerstin Günther joined the Center and is now the Chief Financial and Technology Officer. Campus The main campus is located in Neuherberg, a district of Oberschleißheim, right outside of Munich’s city borders. The campus has a size of 52.3 hectares. In addition, the Center maintains resear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust Sanger Institute
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is located on the Wellcome Genome Campus by the village of Hinxton, outside Cambridge. It shares this location with the European Bioinformatics Institute. It was established in 1992 and named after double Nobel Laureate Frederick Sanger. It was conceived as a large scale DNA sequencing centre to participate in the Human Genome Project, and went on to make the largest single contribution to the gold standard sequence of the human genome. From its inception the institute established and has maintained a policy of data sharing, and does much of its research in collaboration. Since 2000, the institute expanded its mission to understand "the role of genetics in health and disease". The institute now employs around 900 people and engages in five main areas of research: Canc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inbred Strain
Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. However, for some experiments, genetic diversity in the test population may be desired. Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
C57BL/6
C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. Origin The inbred strain of C57BL mice was created in 1921 by C. C. Little at the Bussey Institute for Research in Applied Biology. The substrain "6" was the most popular of the surviving substrains. Little's supervisor William E. Castle had obtained the predecessor strain of C57BL/6, "mouse number 57", from Abbie Lathrop who was breeding inbred strains for mammary tumor research in collaboration with Leo Loeb at the time. Appearance and behavior C57BL/6 mice have a dark brown, nearly black coat. They are more sensitive to noise and odours and are more likely to bite than the more docile laboratory strains such a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BALB/cByJ
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation. History The founding animals of the strain were obtained by Halsey J. Bagg of Memorial Hospital, New York, from a mouse dealer in Ohio in 1913. The name BALB is a concatenation of Bagg and Albino. From 1920, the progeny of the original colony were systematically inbred, sibling to sibling, for 26 generations over 15 years. During this time, the colony passed through the care of a number of scientists, including C.C. Little and E.C. MacDowell at the Carnegie Institution of Washington and H.J. Muller at the University of Texas at Austin.Potter M. History of the BALB/c family, pp 1-5. In: The BALB/c Mouse: Genetics and Immunology, ''Current Topics in Microbiology and Immunology'', Vol. 122. Springer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Knockout Mouse Consortium
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to create knockout mice to study. Many of the targeted alleles are designed so that they can generate both complete and conditional gene knockout mice. The IKMC was initiated on March 15, 2007 at a meeting in Brussels. By 2011, ''Nature'' reported that approximately 17,000 different genes have already been disabled by the consortium, "leaving only around 3,000 more to go". The consortium encompasses four major, high-throughput gene-targeted mutagenesis programs: the National Institutes of Health (NIH)-sponsored Knockout Mouse Program (KOMP) and state-funded Texas Institute for Genomic Medicine (TIGM) in the U.S., the North American Conditional Mouse Mutagenesis (NorCOMM) Program in Canada, and the European Conditional Mouse Mutagenesis (EUCOM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Classical Genetics
Classical genetics is the branch of genetics based solely on visible results of reproductive acts. It is the oldest discipline in the field of genetics, going back to the experiments on Mendelian inheritance by Gregor Mendel who made it possible to identify the basic mechanisms of heredity. Subsequently, these mechanisms have been studied and explained at the molecular level. Classical genetics consists of the techniques and methodologies of genetics that were in use before the advent of molecular biology. A key discovery of classical genetics in eukaryotes was genetic linkage. The observation that some genes do not segregate independently at meiosis broke the laws of Mendelian inheritance and provided science with a way to map characteristics to a location on the chromosomes. Linkage maps are still used today, especially in breeding for plant improvement. After the discovery of the genetic code and such tools of cloning as restriction enzymes, the avenues of investigation open t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics In The United Kingdom
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
