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Ethylpropyllysergamide
''N''-Ethyl-''N''-propyllysergamide (EPLA), also known as lysergic acid ethylpropylamide (LEP or LEP-57), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the amide group has one ethyl group and one propyl group instead of two ethyl groups. The drug shows affinity for serotonin receptors and acts as a serotonin 5-HT2A receptor agonist similarly to LSD. EPLA has about one-third of the potency of LSD in producing psychedelic effects in humans. Its exact dosage has not been reported. EPLA was first described in the scientific literature by at least 1959. It was reportedly encountered as a designer drug A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ... by the 1990s. See also * Lysergic acid methylpr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Lysergamide
Lysergamides, also known as ergoamides or as lysergic acid amides, are amides of lysergic acid (LA). They are ergolines, with some lysergamides being found naturally in ergot as well as other fungi. Lysergamides are notable in containing embedded phenethylamine and tryptamine moieties within their ergoline ring system. The simplest lysergamides are ergine (lysergic acid amide; LSA) and isoergine (iso-lysergic acid amide; iso-LSA). In terms of pharmacology, the lysergamides include numerous serotonin and dopamine receptor agonists, most notably the psychedelic drug lysergic acid diethylamide (LSD) but also a number of pharmaceutical drugs like ergometrine, methylergometrine, methysergide, and cabergoline. Various analogues of LSD, such as the psychedelics ALD-52 (1A-LSD), ETH-LAD, LSZ, and 1P-LSD and the non-hallucinogenic 2-bromo-LSD (BOL-148), have also been developed. Ergopeptines like ergotamine, dihydroergotamine, and bromocriptine are also lysergamides, but with a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Dipropylamide
Lysergic acid dipropylamide (LSDP), also known as ''N'',''N''-dipropyllysergamide (DPL), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the amide group has two propyl substitutions instead of two ethyl substituents. The drug has about 10% or less of the potency of LSD as a psychedelic and its dose is greater than 1mg orally. It has been reported however that, in contrast to LSD, LSDP produces LSD-like autonomic effects at much lower doses (<1mg) than those at which its psychedelic effects occur. The drug was initially thought to be non-hallucinogenic after only being tested at sub-milligram doses. LSDP was first described in the literature by |
Ethylisopropyllysergamide
Ethylisopropyllysergamide (EIPLA) is an analog of lysergic acid diethylamide (LSD). In studies in mice, it was found to have approximately half the potency of LSD. See also * ECPLA * ETFELA * Ethylpropyllysergamide ''N''-Ethyl-''N''-propyllysergamide (EPLA), also known as lysergic acid ethylpropylamide (LEP or LEP-57), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the amide g ... (EPLA) * Methylisopropyllysergamide (MIPLA) References Psychedelic lysergamides {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethylcyclopropyllysergamide
ECPLA (''N''-ethyl-''N''-cyclopropyllysergamide) is an analog of lysergic acid diethylamide (LSD) and an isomer of the LSZ developed by Synex Synthetics. In studies in mice, it was found to have approximately 40% the potency of LSD. See also * ETFELA * EIPLA * Ethylpropyllysergamide ''N''-Ethyl-''N''-propyllysergamide (EPLA), also known as lysergic acid ethylpropylamide (LEP or LEP-57), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the amide g ... (EPLA) * Methylisopropyllysergamide (MIPLA) References Cyclopropyl compounds Psychedelic lysergamides {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methylisopropyllysergamide
Methylisopropyllysergamide (MIPLA), also known as lysergic acid methylisopropylamide, is an analogue of LSD that was originally discovered by Albert Hofmann at Sandoz during the original structure-activity research into LSD. It has subsequently been investigated in more detail by the team led by David E. Nichols at Purdue University. The drug is a structural isomer of LSD, with the alkyl groups on the amide nitrogen having been subjected to a methylene shuffle. MIPLA and its ethylisopropyl homologue EIPLA are the only simple N,N-dialkyl lysergamides that approach the potency of LSD itself, being around 1/3-1/2 the potency of LSD, while all other dialkyl analogues tested (dimethyl, dipropyl, methylethyl etc.) are only around 1/10 as potent as LSD, although some N-monoalkyl lysergamides such as the ''sec''-butyl and ''t''-butyl derivatives were also found to show an activity profile and potency comparable to LSD, and the mono-isopropyl derivative is only slightly weaker than MIPL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonergic Psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. They pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dose (biochemistry)
A dose is a measured quantity of a medicine, nutrient, or pathogen that is delivered as a unit. The greater the quantity delivered, the larger the dose. Doses are most commonly measured for compounds in medicine. The term is usually applied to the quantity of a drug or other agent administered for therapeutic purposes, but may be used to describe any case where a substance is introduced to the body. In nutrition, the term is usually applied to how much of a specific nutrient is in a person's diet or in a particular food, meal, or dietary supplement. For bacterial or Virus, viral agents, dose typically refers to the amount of the pathogen required to infect a host. In clinical pharmacology, ''dose'' refers to the amount of drug administered to a person, and Dosage (pharmacology), ''dosage'' is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week"). Exposure assessment, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Propyl Compounds
In organic chemistry, a propyl group is a three-carbon alkyl substituent with chemical formula for the linear form. This substituent form is obtained by removing one hydrogen atom attached to the terminal carbon of propane. A propyl substituent is often represented in organic chemistry with the symbol Pr (not to be confused with the element praseodymium). An isomeric form of propyl is obtained by moving the point of attachment from a terminal carbon atom to the central carbon atom, named isopropyl or 1-methylethyl. To maintain four substituents on each carbon atom, one hydrogen atom has to be moved from the middle carbon atom to the carbon atom which served as attachment point in the ''n''-propyl variant, written as . Linear propyl is sometimes termed normal and hence written with a prefix ''n''- (i.e., ''n-''propyl), as the absence of the prefix ''n''- does not indicate which attachment point is chosen, i.e. absence of prefix does not automatically exclude the possibility of i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethyl Compounds
Ethyl may refer to: Arts and entertainment *Ethyl Sinclair, a character in the ''Dinosaurs'' television show Science and technology * Ethyl group, an organic chemistry moiety * Ethyl alcohol (or ethanol) * Ethyl Corporation, a fuel additive company ** Tetraethyllead Tetraethyllead (commonly styled tetraethyl lead), abbreviated TEL, is an organolead compound with the formula lead, Pb(ethyl group, C2H5)4. It was widely used as a fuel additive for much of the 20th century, first being mixed with gasoline begi ...-treated gasoline See also * Ethel (other) {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2A Agonists
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. Most of the body's serotonin—about 90%—is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1–2% is found in the CNS. Serotonin acts as both a vasoconstrictor and v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Diallylamide
''N'',''N''-Diallyllysergamide (DAL, as the tartrate salt), also known as lysergic acid diallylamide, is a psychedelic lysergamide related to lysergic acid diethylamide (LSD). In their book ''TiHKAL'', Alexander and Ann Shulgin describe it as being "an order of magnitude less potent than LSD itself". See also * Substituted lysergamide Lysergamides, also known as ergoamides or as lysergic acid amides, are amides of lysergic acid (LA). They are ergolines, with some lysergamides being found naturally in ergot as well as other fungi. Lysergamides are notable in containing embed ... * Lysergic acid dimethylamide (DAM-57) * Lysergic acid dipropylamide (DPL) * Lysergic acid dibutylamide (LBB-66) References Allylamines Psychedelic lysergamides Serotonin receptor agonists {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Dimethylamide
DAM-57, also known as ''N'',''N''-dimethyllysergamide (DAM) or as lysergic acid dimethylamide, is a derivative of ergine. There has been a single report of observing N,N-dimethyl-D-lysergamide in the illicit drug market. This compound did induce autonomic disturbances at oral levels of some ten times the dosage required for lysergic acid diethylamide (LSD), presumably in the high hundreds of micrograms. There is some disagreement as to whether there were psychic changes observed.; It was first described in the scientific literature by Albert Hofmann and colleagues by 1955. See also * Substituted lysergamide * Lysergic acid methylamide (LAM) * Lysergic acid dipropylamide (DPL) * Lysergic acid diallylamide ''N'',''N''-Diallyllysergamide (DAL, as the tartrate salt), also known as lysergic acid diallylamide, is a psychedelic lysergamide related to lysergic acid diethylamide (LSD). In their book ''TiHKAL'', Alexander and Ann Shulgin describe it as bei ... (DAL) References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
