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Esophageal Atresia
Esophageal atresia is a congenital medical condition (birth defect) that affects the alimentary tract. It causes the esophagus to end in a blind-ended pouch rather than connecting normally to the stomach. It comprises a variety of congenital anatomic defects that are caused by an abnormal embryological development of the esophagus. It is characterized anatomically by a congenital obstruction of the esophagus with interruption of the continuity of the esophageal wall. Pathophysiology The genetic causes of EA/TEF include chromosome anomalies or variants in genes involved in critical developmental processes which are dosage sensitive. Several EA/TEF risk genes have been discovered include the transcriptional regulators SOX2, MYCN, CHD7, FANCB, and members of FOX transcription factor family. Others plausible candidate genes in the etiology of EA/TEF were identified as APC2, AMER3, PCDH1, GTF3C1, POLR2B, RAB3GAP2, and ITSN1. Signs and symptoms This birth defect arises in the fou ...
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Pediatrics
Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine that involves the medical care of infants, children, Adolescence, adolescents, and young adults. In the United Kingdom, pediatrics covers many of their youth until the age of 18. The American Academy of Pediatrics recommends people seek pediatric care through the age of 21, but some pediatric subspecialists continue to care for adults up to 25. Worldwide age limits of pediatrics have been trending upward year after year. A physician, medical doctor who specializes in this area is known as a pediatrician, or paediatrician. The word ''pediatrics'' and its cognates mean "healer of children", derived from the two Ancient Greek, Greek words: (''pais'' "child") and (''iatros'' "doctor, healer"). Pediatricians work in clinics, research centers, universities, general hospitals and children's hospitals, including those who practice pediatric subspecialties (e.g. neonatology requires reso ...
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VACTERL Association
The VACTERL association (also VATER association, and less accurately VACTERL syndrome) refers to a recognized group of birth defects which tend to co-occur (see below). This pattern is a recognized association, as opposed to a syndrome, because there is no known pathogenetic cause to explain the grouped incidence. Each child with this condition can be unique. At present this condition is treated after birth with issues being approached one at a time. Some infants are born with symptoms that cannot be treated and they do not survive. VACTERL association can be linked to other similar conditions such as Klippel Feil and Goldenhar syndrome including crossovers of conditions. No specific genetic or chromosome problem has been identified with VACTERL association. VACTERL can be seen with some chromosomal defects such as Trisomy 18 and is more frequently seen in babies of diabetic mothers. VACTERL association, however, is most likely caused by multiple factors. VACTERL association s ...
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Anastomosis
An anastomosis (, : anastomoses) is a connection or opening between two things (especially cavities or passages) that are normally diverging or branching, such as between blood vessels, leaf veins, or streams. Such a connection may be normal (such as the foramen ovale in a fetus' heart) or abnormal (such as the patent foramen ovale in an adult's heart); it may be acquired (such as an arteriovenous fistula) or innate (such as the arteriovenous shunt of a metarteriole); and it may be natural (such as the aforementioned examples) or artificial (such as a surgical anastomosis). The reestablishment of an anastomosis that had become blocked is called a reanastomosis. Anastomoses that are abnormal, whether congenital or acquired, are often called fistulas. The term is used in medicine, biology, mycology, geology, and geography. Etymology Anastomosis: medical or Modern Latin, from Greek ἀναστόμωσις, anastomosis, "outlet, opening", Greek ana- "up, on, upon", stoma "mouth" ...
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Mario Zaritzky
Mario Zaritzky (born December 16, 1956, in La Plata, Argentina) is MD, scientist and inventor and currently lives and works as an associate professor of Radiology at Jackson Memorial Center. Previously, he was an assistant professor in the Department of Pediatric Radiology Department of Radiology, University of Chicago in Chicago, Illinois, USA. Zaritzky coordinated the Argentine Network of Science in Midwestern, United States, from the Ministry of Science, Technology and Productive Innovation Programme of Argentina. Training He graduated as a doctor in 1980 at the University of La Plata in Argentina, and obtained certification as a specialist in pediatric surgery in 1987 and Pediatric Radiology, 1998, College of Medicine, Buenos Aires Province, Argentina. He worked as surgeon and later as medical and interventional radiologist at the Children's Hospital " Sor María Ludovica" of the city of La Plata, from 1980 to 2004. From 2004 to 2006 was instructor in the Department of Radiolo ...
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Gastrostomy
A gastrostomy is the creation of an artificial external opening into the stomach for nutritional support or gastric decompression. Typically this would include an incision in the patient's epigastrium as part of a formal operation. When originally devised over a century ago the procedure was completed through open surgery using the Stamm technique. It can be performed through surgical approach, percutaneous approach by interventional radiology, percutaneous endoscopic gastrostomy (PEG) or percutaneous ultrasound gastrostomy (PUG). A gastrostomy may be required due to illness, trauma or disability impacting upon the ability to eat or swallow safely, or conditions causing increased nutritional requirement and once formed (or for some techniques, during formation), a gastrostomy tube is inserted. Techniques The Stamm gastrostomy is an open technique, requiring an upper midline laparotomy and gastrotomy, with the catheter brought out in the left hypochondrium. It was first devi ...
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Esophageal Atresia For Website
Esophageal can refer to: * The esophagus * Esophageal arteries * Esophageal glands * Esophageal cancer Esophageal cancer (American English) or oesophageal cancer (British English) is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach. Symptoms often include dysphagia, difficulty in swallowing and weigh ... {{disambig ...
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Agenesis
In medicine, agenesis () refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue. Many forms of agenesis are referred to by individual names, depending on the organ affected: * Agenesis of the corpus callosum - failure of the Corpus callosum to develop *Renal agenesis - failure of one or both of the kidneys to develop * Amelia - failure of the arms or legs to develop * Penile agenesis - failure of penis to develop * Müllerian agenesis - failure of the uterus and part of the vagina to develop * Agenesis of the gallbladder - failure of the Gallbladder to develop. A person may not realize they have this condition unless they undergo surgery or medical imaging, since the gallbladder is neither externally visible nor essential. __TOC__ Eye agenesis Eye agenesis is a medical condition in which people are born with no eyes. Dental & oral agenesis * Anodontia, absence of all primary or permanent teeth. * Aglossia, ...
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Robert Edward Gross
Robert Edward Gross (July 2, 1905 – October 11, 1988) was an American surgeon and a medical researcher. He performed early work in pediatric heart surgery at Boston Children's Hospital. Gross was president of the American Association for Thoracic Surgery, a member of the National Academy of Sciences and a fellow of the American Academy of Arts and Sciences. Biography The National Academies Press called him "one of America's great pioneers of surgery". ''The New York Times'' said that he did "pioneering work in the field of cardiac surgery". According to his obituary in ''The New York Times'', in 1938 Gross "performed the first surgical correction of one of the most common congenital heart disorders in children", referring to the ligation of the patent ductus. Ten years later he performed the first surgery to graft artery tissue from one person into another, thus making a leap in methods of repairing of damaged arteries. He also developed a method of cutting into a heart with a ...
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Tracheoesophageal Fistula
A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula) between the esophagus and the trachea. TEF is a common congenital abnormality, but when occurring late in life is usually the sequela of surgical procedures such as a laryngectomy. Presentation Tracheoesophageal fistula is suggested in a newborn by copious salivation associated with choking, coughing, vomiting, and cyanosis coincident with the onset of feeding. Esophageal atresia and the subsequent inability to swallow typically cause polyhydramnios in utero. Rarely it may present in an adult. Complications Surgical repair can sometimes result in complications, including: * Stricture, due to gastric acid erosion of the shortened esophagus * Leak of contents at the point of anastomosis * Recurrence of fistula * Gastro-esophageal reflux disease * Dysphagia * Asthma-like symptoms, such as persistent coughing/wheezing * Recurrent chest infections * Tracheomalacia Associations ...
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Vertebrate Trachea
The trachea (: tracheae or tracheas), also known as the windpipe, is a cartilaginous tube that connects the larynx to the bronchi of the lungs, allowing the passage of air, and so is present in almost all animals' lungs. The trachea extends from the larynx and branches into the two primary bronchi. At the top of the trachea, the cricoid cartilage attaches it to the larynx. The trachea is formed by a number of horseshoe-shaped rings, joined together vertically by overlying ligaments, and by the trachealis muscle at their ends. The epiglottis closes the opening to the larynx during swallowing. The trachea begins to form in the second month of embryo development, becoming longer and more fixed in its position over time. Its epithelium is lined with column-shaped cells that have hair-like extensions called cilia, with scattered goblet cells that produce protective mucins. The trachea can be affected by inflammation or infection, usually as a result of a viral illness affectin ...
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Fistula
In anatomy, a fistula (: fistulas or fistulae ; from Latin ''fistula'', "tube, pipe") is an abnormal connection (i.e. tube) joining two hollow spaces (technically, two epithelialized surfaces), such as blood vessels, intestines, or other hollow organs to each other, often resulting in an abnormal flow of fluid from one space to the other. An anal fistula connects the anal canal to the perianal skin. An anovaginal or rectovaginal fistula is a hole joining the anus or rectum to the vagina. A colovaginal fistula joins the space in the colon to that in the vagina. A urinary tract fistula is an abnormal opening in the urinary tract or an abnormal connection between the urinary tract and another organ. An abnormal communication (i.e. hole or tube) between the bladder and the uterus is called a vesicouterine fistula, while if it is between the bladder and the vagina it is known as a vesicovaginal fistula, and if between the urethra and the vagina: a urethrovaginal fistu ...
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