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Epstein–Barr Virus Nuclear Antigen 2
The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six Epstein–Barr virus, EBV viral nuclear proteins expressed in latently infected B cell, B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells. EBNA2 acts as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins, JK recombination signal-binding protein (RBPJ, RBP-JK), and SPI1, PU.1 as well as working with multiple members of the RNA polymerase II transcription complex. Structure EBNA2 has an acidic activation domain, which can interact with many different general transcription factors and co-activators. Regulation of transcription initiation and elongation by EBNA 2 is done part through cyclin-dependent kinase 9 (CDK9) dependent phosphorylation of the RNA polymerase C-terminus, C-terminal domain. Mechanism EBNA2 requires C-promoter binding factor 1 (CBF1) to aid in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epstein–Barr Virus
The Epstein–Barr virus (EBV), formally called ''Human gammaherpesvirus 4'', is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. It is best known as the cause of infectious mononucleosis ("mono" or "glandular fever"). It is also associated with various non-malignant, premalignant, and malignant Epstein–Barr virus-associated lymphoproliferative diseases such as Burkitt lymphoma, hemophagocytic lymphohistiocytosis, and Hodgkin's lymphoma; non-lymphoid malignancies such as gastric cancer and nasopharyngeal carcinoma; and conditions associated with human immunodeficiency virus such as hairy leukoplakia and central nervous system lymphomas. The virus is also associated with the childhood disorders of Alice in Wonderland syndrome and acute cerebellar ataxia and, by some evidence, higher risks of developing certain autoimmune diseases, especially dermatomyositis, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
