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Epigenetic Clock Theory Of Aging
Steve Horvath is a German–American aging researcher, geneticist, and biostatistician. He is a professor at the University of California, Los Angeles. He is known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation network analysis. His work on the genomic biomarkers of aging, the aging process, and many age related diseases/conditions has earned him several research awards. Horvath is a principal investigator at the anti-aging startup Altos Labs and co-founder of nonprofit Clock Foundation. Background Horvath was born 1967 in Frankfurt, Germany; as the family name '' Horvath'' indicates, he is of Hungarian ancestry. He received his Diplom in Mathematics and Physics at Technische Universität Berlin, graduating in 1989. He received his Ph.D. in mathematics at the UNC Chapel Hill in 1995 and his Sc.D. in biostatistics at Harvard in 2000. In 2000, Horvath joined the faculty of the Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frankfurt
Frankfurt am Main () is the most populous city in the States of Germany, German state of Hesse. Its 773,068 inhabitants as of 2022 make it the List of cities in Germany by population, fifth-most populous city in Germany. Located in the foreland of the Taunus on its namesake Main (river), Main, it forms a continuous conurbation with Offenbach am Main; Frankfurt Rhein-Main Regional Authority, its urban area has a population of over 2.7 million. The city is the heart of the larger Rhine-Main metropolitan region, which has a population of more than 5.8 million and is Germany's Metropolitan regions in Germany, second-largest metropolitan region after the Rhine-Ruhr metropolitan region, Rhine-Ruhr region and the List of EU metropolitan regions by GDP#2021 ranking of top four German metropolitan regions, fourth largest metropolitan region by GDP in the European Union (EU). Frankfurt is one of the ''de facto'' four main capitals of the European Union (alongside Brussels, Luxembourg Cit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomarkers Of Aging
Biomarkers of aging are biomarkers that could predict functional capacity at some later age better than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age. Validated biomarkers of aging would allow for testing interventions to life extension, extend lifespan, because changes in the biomarkers would be observable throughout the lifespan of the organism. Although maximum lifespan would be a means of validating biomarkers of aging, it would not be a practical means for long-lived species such as humans because longitudinal studies would take far too much time. Ideally, biomarkers of aging should assay the biological process of aging and not a predisposition to disease, should cause a minimal amount of trauma to assay in the organism, and should be reproducibly measurable during a short interval compared to the lifespan of the organism. An assemblage of biomarker data for an organism could b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features Peer review, peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2022 ''Journal Citation Reports'' (with an ascribed impact factor of 50.5), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in the autumn of 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander MacMillan (publisher), Alexander MacMillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Methylation
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter (genetics), promoter, DNA methylation typically acts to repress gene Transcription (genetics), transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements, aging, and carcinogenesis. As of 2016, two nucleobases have been found on which natural, enzymatic DNA methylation takes place: adenine and cytosine. The modified bases are N6-methyladenine,D. B. Dunn, J. D. Smith: "The occurrence of 6-methylaminopurine in deoxyribonucleic acids". In: ''Biochem J.'' 68(4), Apr 1958, S. 627–636. [//www.ncbi.nlm.nih.gov/pubmed/13522672?dopt=Abstract PMID 13522672]. . 5-methylcytosineB. F. Vanyushin, S. G. Tkacheva, A. N. Belozers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biostatistics
Biostatistics (also known as biometry) is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results. History Biostatistics and genetics Biostatistical modeling forms an important part of numerous modern biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools. Gregor Mendel started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary Darwinism. Francis Galton tried to expand Mendel's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics
Human genetics is the study of inheritance as it occurs in Human, human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes are the common factor of the qualities of most human-inherited traits. Study of human genetics can answer questions about human nature, can help understand diseases and the development of effective treatment and help us to understand the genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. For information on the genetics of DNA repair defects related to accelerated aging and/or increased risk of cancer please see: DNA repair-deficiency disorder. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California
The University of California (UC) is a public university, public Land-grant university, land-grant research university, research university system in the U.S. state of California. Headquartered in Oakland, California, Oakland, the system is composed of its ten campuses at University of California, Berkeley, Berkeley, University of California, Davis, Davis, University of California, Irvine, Irvine, University of California, Los Angeles, Los Angeles, University of California, Merced, Merced, University of California, Riverside, Riverside, University of California, San Diego, San Diego, University of California, San Francisco, San Francisco, University of California, Santa Barbara, Santa Barbara, and University of California, Santa Cruz, Santa Cruz, along with numerous research centers and academic centers abroad. The system is the state's land-grant university. In 1900, UC was one of the founders of the Association of American Universities and since the 1970s seven of its campuse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard T
Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyman John Harvard (clergyman), John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of Colonial history of the United States, colonial-era Massachusetts Bay Colony. While never formally affiliated with any Religious denomination, denomination, Harvard trained Congregationalism in the United States, Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of North Carolina At Chapel Hill
The University of North Carolina at Chapel Hill (UNC, UNC–Chapel Hill, or simply Carolina) is a public university, public research university in Chapel Hill, North Carolina, United States. Chartered in 1789, the university first began enrolling students in 1795, making it the oldest public university in the United States, oldest public university in the United States. The university offers degrees in over 70 courses of study and is administratively divided into 13 separate professional schools and a primary unit, the College of Arts & Sciences. It is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity" and is a member of the Association of American Universities (AAU). The National Science Foundation ranked UNC–Chapel Hill ninth among American universities for research and development expenditures in 2023 with $1.5 billion. Its Financial endowment, endowment is $5.7 billion, making it the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original research. The name of the degree is most often abbreviated PhD (or, at times, as Ph.D. in North American English, North America), pronounced as three separate letters ( ). The University of Oxford uses the alternative abbreviation "DPhil". PhDs are awarded for programs across the whole breadth of academic fields. Since it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and, in some cases, defend their work before a panel of other experts in the field. In many fields, the completion of a PhD is typically required for employment as a university professor, researcher, or scientist. Definition In the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diplom
A ''Diplom'' (, from ) is an academic degree in the German-speaking countries Germany, Austria, and Switzerland and a similarly named degree in some other European countries including Albania, Bulgaria, Belarus, Bosnia and Herzegovina, Croatia, Estonia, Finland, Poland, Russia, and Ukraine and only for engineers in France, Greece, Hungary, North Macedonia, Romania, Serbia, Slovenia, and Brazil. History The Diplom originates from the French Diplôme (''Diplôme de l'ordre impérial de la légion d'honneur'') describing a certificate devised during the Second French Empire to bestow honours upon outstanding citizens and soldiers of the imperial French army to promote them into the Legion of Honour since 1862. The Magister degree was the original graduate degree at German-speaking universities. In Germany the Diplom dates back to the pre-republican period: In October 1899 the engineering degree ''Diplom'' was announced by a ''supreme decree'' of the German emperor Wilhelm II in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hungarians
Hungarians, also known as Magyars, are an Ethnicity, ethnic group native to Hungary (), who share a common Culture of Hungary, culture, Hungarian language, language and History of Hungary, history. They also have a notable presence in former parts of the Kingdom of Hungary. The Hungarian language belongs to the Ugric languages, Ugric branch of the Uralic languages, Uralic language family, alongside the Khanty languages, Khanty and Mansi languages, Mansi languages. There are an estimated 14.5 million ethnic Hungarians and their descendants worldwide, of whom 9.6 million live in today's Hungary. About 2 million Hungarians live in areas that were part of the Kingdom of Hungary before the Treaty of Trianon in 1920 and are now parts of Hungary's seven neighbouring countries, Hungarians in Slovakia, Slovakia, Hungarians in Ukraine, Ukraine, Hungarians in Romania, Romania, Hungarians in Serbia, Serbia, Hungarians of Croatia, Croatia, Prekmurje, Slovenia, and Hungarians in Austria, Aust ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
