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Elaine Fuchs
Elaine V. Fuchs is an American cell biologist known for her work on the biology and molecular mechanisms of mammalian skin and skin diseases, who helped lead the modernization of dermatology. Fuchs pioneered reverse genetics approaches, which assess protein function first and then assess its role in development and disease. In particular, Fuchs researches skin stem cells and their production of hair and skin. She is an investigator at the Howard Hughes Medical Institute and the Rebecca C. Lancefield Professor of Mammalian Cell Biology and Development at The Rockefeller University. Early life and education Fuchs grew up outside Chicago, in a family of scientists—her father, aunt, and sister were also scientists, and her family encouraged her to pursue higher education.Fiona Watt. "Women in Cell Science: Elaine Fuchs", Journal of Cell Science, v. 117, n. 4877-4879 (2004). She said those influences were especially important to her as a child. During an interview with Faiza E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Illinois
The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public university, public land-grant university, land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United States. Established in 1867, it is the founding campus and Flagship#Colleges and universities in the United States, flagship institution of the University of Illinois System. With over 59,000 students, the University of Illinois is one of the List of United States public university campuses by enrollment, largest public universities by enrollment in the United States. The university contains 16 schools and colleges and offers more than 150 undergraduate and over 100 graduate programs of study. The university holds 651 buildings on and its annual operating budget in 2016 was over $2 billion. The University of Illinois Urbana-Champaign also operates Research Park at the University of Illinois Urbana-Champaign, a research park home to innova ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stem Cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. In mammals, roughly 50 to 150 cells make up the inner cell mass during the blastocyst stage of embryonic development, around days 5–14. These have stem-cell capability. '' In vivo'', they eventually differentiate into all of the body's cell types (making them pluripotent). This process starts with the differentiation into the three germ layers – the ectoderm, mesoderm and endoderm – at the gastrulation stage. However, whe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Mice
The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. Laboratory animal sources for these mice are usually of the species ''Mus musculus''. They are the most commonly used mammalian research model and are used for research in genetics, physiology, psychology, medicine and other scientific disciplines. Mice belong to the Euarchontoglires clade, which includes humans. This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. The laboratory mouse genome has been sequenced and many mouse genes have human homologues. Lab mice are sold at pet stores for snake food and can also be kept as pets. Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (''Peromyscus leucopus'') and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million. The institute has an endowment of $22.6 billion, making it the second-wealthiest philanthropic organization in the United States and the second-best-endowed medical research foundation in the world. HHMI is the former owner of the Hughes Aircraft Company, an American aerospace firm that was divested to vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDNA
In genetics, complementary DNA (cDNA) is DNA that was reverse transcribed (via reverse transcriptase) from an RNA (e.g., messenger RNA or microRNA). cDNA exists in both single-stranded and double-stranded forms and in both natural and engineered forms. In engineered forms, it often is a copy (replicate) of the naturally occurring DNA from any particular organism's natural genome; the organism's own mRNA was naturally transcribed from its DNA, and the cDNA is reverse transcribed from the mRNA, yielding a duplicate of the original DNA. Engineered cDNA is often used to express a specific protein in a cell that does not normally express that protein (i.e., heterologous expression), or to sequence or quantify mRNA molecules using DNA based methods (qPCR, RNA-seq). cDNA that codes for a specific protein can be transferred to a recipient cell for expression as part of recombinant DNA, often bacterial or yeast expression systems. cDNA is also generated to analyze transcriptomic pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keratin
Keratin () is one of a family of structural fibrous proteins also known as ''scleroproteins''. It is the key structural material making up Scale (anatomy), scales, hair, Nail (anatomy), nails, feathers, horn (anatomy), horns, claws, Hoof, hooves, and the outer layer of skin in vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents. Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong mineralization (biology), unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive keratinization participate in fortification of certain tissues such as in horns of cattle and rhinos, and armadillos' osteoderm. The only other biology, biological matter known to approximate the toughness of keratinized tissue is chitin. Keratin comes in two types: the primitive, softer forms found in all vertebrates and the harder, derived forms fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chicago, South Side, near the shore of Lake Michigan about from Chicago Loop, the Loop. The university is composed of an College of the University of Chicago, undergraduate college and four graduate divisions: Biological Science, Arts & Humanities, Physical Science, and Social Science, which include various organized departments and institutes. In addition, the university operates eight professional schools in the fields of University of Chicago Booth School of Business, business, Crown Family School of Social Work, Policy, and Practice, social work, University of Chicago Divinity School, divinity, Graham School of Continuing Liberal and Professional Studies, continuing studies, Harris School of Public Policy, public policy, University of Chi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keratinocyte
Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. Basal cells in the basal layer (''stratum basale'') of the skin are sometimes referred to as basal keratinocytes. Keratinocytes form a barrier against environmental damage by heat, UV radiation, water loss, pathogenic bacteria, fungi, parasites, and viruses. A number of structural proteins, enzymes, lipids, and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinocytes differentiate from epidermal stem cells in the lower part of the epidermis and migrate towards the surface, finally becoming corneocytes and eventually being shed, which happens every 40 to 56 days in humans. Function The primary function of keratinocytes is the formation of a barrier against environmental damage by heat, UV radiation, dehydration, pathogenic bacteria, fungi, parasites, and viruses. Pathoge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and science. In response to the increasing Technological and industrial history of the United States, industrialization of the United States, William Barton Rogers organized a school in Boston to create "useful knowledge." Initially funded by a land-grant universities, federal land grant, the institute adopted a Polytechnic, polytechnic model that stressed laboratory instruction in applied science and engineering. MIT moved from Boston to Cambridge in 1916 and grew rapidly through collaboration with private industry, military branches, and new federal basic research agencies, the formation of which was influenced by MIT faculty like Vannevar Bush. In the late twentieth century, MIT became a leading center for research in compu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graduate Record Examination
The Graduate Record Examinations (GRE) is a standardized test that is part of the admissions process for many graduate schools in the United States and Canada and a few other countries. The GRE is owned and administered by Educational Testing Service (ETS). The test was established in 1936 by the Carnegie Foundation for the Advancement of Teaching. According to ETS, the GRE aims to measure verbal reasoning, quantitative reasoning, analytical writing, and critical thinking skills that have been acquired over a long period of learning. The content of the GRE consists of certain specific data analysis or interpretation, arguments and reasoning, algebra, geometry, arithmetic, and vocabulary sections. The GRE General Test is offered as a computer-based exam administered at testing centers and institution owned or authorized by Prometric. In the graduate school admissions process, the level of emphasis that is placed upon GRE scores varies widely among schools and departments. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Idi Amin
Idi Amin Dada Oumee (, ; 30 May 192816 August 2003) was a Ugandan military officer and politician who served as the third president of Uganda from 1971 until Uganda–Tanzania War, his overthrow in 1979. He ruled as a Military dictatorship, military dictator and is considered one of the most brutal Despotism, despots in modern world history. Amin was born to a Kakwa people, Kakwa father and Lugbara people, Lugbara mother. In 1946, he joined the King's African Rifles (KAR) of the British Colonial Army as a cook. He rose to the rank of lieutenant, taking part in British Empire, British actions against Somali rebels and then the Mau Mau rebellion, Mau Mau Uprising in Kenya Colony, Kenya. Uganda gained independence from the United Kingdom in 1962, and Amin remained in the Uganda Army (1962–1971), army, rising to the position of deputy army commander in 1964 and being appointed commander two years later. He became aware that Ugandan president Milton Obote was planning to arrest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
