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Edward De Robertis
Edward Michael De Robertis (born June 6, 1947) is an American embryologist and Professor at the University of California, Los Angeles. His work has contributed to the finding of conserved molecular processes of embryonic inductions that result in tissue differentiations during animal development. He was elected to the National Academy of Sciences in 2013, worked for the Howard Hughes Medical Institute for 26 years, and holds a Distinguished Professor at the University of California, Los Angeles. In 2009 Pope Benedict XVI appointed De Robertis to a lifetime position in the Pontifical Academy of Sciences, and in 2022 Pope Francis appointed him Councillor of the Academy for four years. Early life and education Edward De Robertis was born on June 6, 1947, in Cambridge, Massachusetts, while his father, neurobiologist Eduardo De Robertis, was an MIT postdoctoral fellow. From the age of three, he was reared in Uruguay, where he received his medical degree at age 24 from the Universida ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge, Massachusetts
Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 United States census, 2020 U.S. census was 118,403, making it the most populous city in the county, the List of municipalities in Massachusetts, fourth-largest in Massachusetts behind Boston, Worcester, Massachusetts, Worcester, and Springfield, Massachusetts, Springfield, and List of cities in New England by population, ninth-most populous in New England. The city was named in honor of the University of Cambridge in Cambridge, England, which was an important center of the Puritans, Puritan theology that was embraced by the town's founders. Harvard University, an Ivy League university founded in Cambridge in 1636, is the oldest institution of higher learning in the United States. The Massachusetts Institute of Technology (MIT), Lesley University, and Hult Inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of The Republic (Uruguay)
The University of the Republic (, sometimes ''UdelaR'') is a public university, public research university in Montevideo, Uruguay. It is the country's oldest and largest university, as well as one of the largest public universities in South America in List of largest universities and university networks by enrollment, terms of enrollment. Established in 1849, it has educated the vast majority of Uruguay's professionals throughout history and has maintained a leading role in advancing academic research and higher education. The University of the Republic enrolls more than 140,000 students and is organized into 16 independent faculties. It administers 7 university schools and scientific institutes, the Hospital Clinic Manuel Quintela, as well as three regional university centers that serve different parts of the country. History The process of founding the country's first public university began on 11 June 1833, when a law proposed by then-Senator Dámaso Antonio Larrañaga was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysosomes
A lysosome () is a membrane-bound organelle that is found in all mammalian cells, with the exception of red blood cells (erythrocytes). There are normally hundreds of lysosomes in the cytosol, where they function as the cell’s degradation center. Their primary responsibility is catabolic degradation of proteins, polysaccharides and lipids into their respective building-block molecules: amino acids, monosaccharides, and free fatty acids. The breakdown is done by various enzymes, for example proteases, glycosidases and lipases. With an acidic lumen limited by a single-bilayer lipid membrane, the lysosome holds an environment isolated from the rest of the cell. The lower pH creates optimal conditions for the over 60 different hydrolases inside. Lysosomes receive extracellular particles through endocytosis, and intracellular components through autophagy. They can also fuse with the plasma membrane and secrete their contents, a process called lysosomal exocytosis. After degradation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. Endosomes can be classified as early, sorting, or late depending on their stage post internalization. Endosomes represent a major sorting compartment of the endomembrane system in cells. Function Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome. For example, low-density lipoprotein (LDL) is taken into the cell by binding to the LDL receptor at the cell surface. Upon reaching early endosomes, the LDL dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macropinocytosis
In cellular biology, pinocytosis, otherwise known as fluid endocytosis and bulk-phase pinocytosis, is a mode of endocytosis in which small molecules dissolved in extracellular fluid are brought into the cell through an invagination of the cell membrane, resulting in their containment within a small vesicle inside the cell. These pinocytotic vesicles then typically fuse with early endosomes to hydrolyze (break down) the particles. Pinocytosis is variably subdivided into categories depending on the molecular mechanism and the fate of the internalized molecules. Function In humans, this process occurs primarily for absorption of fat droplets. In endocytosis the cell plasma membrane extends and folds around desired extracellular material, forming a pouch that pinches off creating an internalized vesicle. The invaginated pinocytosis vesicles are much smaller than those generated by phagocytosis. The vesicles eventually fuse with the lysosome, whereupon the vesicle contents are diges ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wnt Signaling Pathway
In cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tolloid-like Metalloproteinase
Tolloid-like protein 1 is a protein that in humans is encoded by the ''TLL1'' gene. This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin Chordin (from Greek χορδή, string, catgut) is a protein with a prominent role in dorsal–ventral patterning during early embryonic development. In humans it is encoded for by the ''CHRD'' gene. History Chordin was originally identified ... at similar cleavage sites. In clinical context, TLL1 was mostly associated with atrial septal defect in an autosomal dominant mode of inheritance of loss-of-function mutations. However, functional studies have also linked its gain-of-function with mitral valve prolapse. References Further reading * * * * * * * * {{gene-4-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bone Morphogenetic Protein
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signalling in pathological processes. Cancerous disease often involves misregulation of the BMP signalling system. Absence of BMP signalling is, for instance, an important factor in the progression of colon cancer, and conversely, overactivation of BMP signalling following reflux-induced esophagitis provokes Barrett's esophagus and is thus instrumental in the development of esophageal adenocarcinoma. Recombinant human BMPs (rhBMPs) are used in orthopedic applications such as spinal fusions, nonunions, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chordin
Chordin (from Greek χορδή, string, catgut) is a protein with a prominent role in dorsal–ventral patterning during early embryonic development. In humans it is encoded for by the ''CHRD'' gene. History Chordin was originally identified in the African clawed frog (''Xenopus laevis'') in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. It was first hypothesized that chordin plays a role in the dorsal homeobox genes in Spemann's organizer. The chordin gene was discovered through its activation following use of gsc ( goosecoid) and Xnot mRNA injections. The discoverers of chordin concluded that it is expressed in embryo regions where gsc and Xnot were also expressed, which included the prechordal plate, the notochord, and the chordoneural hinge. The expression of the gene in these regions led to the name chordin. Initial functions of chordin were thought to include recruitment of neighboring cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hilde Mangold
Hilde Mangold (20 October 1898 – 4 September 1924) (née Proescholdt) was a German embryologist who was best known for her 1923 dissertation which was the foundation for her mentor, Hans Spemann's, 1935 Nobel Prize in Physiology or Medicine for the discovery of the embryonic organizer,Mangold, Hilde (Proescholdt) by Marilyn Bailey Ogilvie and Joy Dorothy Harvey in ''The Biographical Dictionary of Women in Science''. "one of the very few doctoral theses in biology that have directly resulted in the awarding of a Nobel Prize".''Developmental Biology''. 10th ed. by Scott F. Gilbert. The general effect she demonstrated is known as embryonic induction, that is, the capacity of some cells to direct the developmental trajectory of other cells, one of the first steps towards cloning. Induction remains a fundamental concept and area of ongoing research in the field. Biography Hilde Proescholdt was born in Gotha, Thuringia, a province in central-eastern Germany on October 20, 1898. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Spemann
Hans Spemann (; 27 June 1869 – 9 September 1941) was a German embryologist who was awarded a Nobel Prize in Physiology or Medicine in 1935 for his student Hilde Mangold's discovery of the effect now known as embryonic induction, an influence, exercised by various parts of the embryo, that directs the development of groups of cells into particular tissues and organs, one of the first steps towards cloning. Spemann added his name as an author to Hilde Mangold's dissertation (although she objected) and won a Nobel Prize for her work. Biography Hans Spemann was born in Stuttgart, the eldest son of publisher Wilhelm Spemann and his wife Lisinka, née Hoffman. After he left school in 1888 he spent a year in his father's business, then, in 1889–1890, he did military service in the Kassel Hussars followed by a short time as a bookseller in Hamburg. In 1891 he entered the University of Heidelberg where he studied medicine, taking his preliminary examination in 1893. There he met th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolutionary Developmental Biology
Evolutionary developmental biology, informally known as evo-devo, is a field of biological research that compares the developmental biology, developmental processes of different organisms to infer how developmental processes evolution, evolved. The field grew from 19th-century beginnings, where embryology faced a mystery: zoology, zoologists did not know how embryogenesis, embryonic development was controlled at the molecular level. Charles Darwin noted that having similar embryos implied common ancestry, but little progress was made until the 1970s. Then, recombinant DNA technology at last brought embryology together with molecular genetics. A key early discovery was that of homeotic genes that regulate development in a wide range of eukaryotes. The field is composed of multiple core evolutionary concepts. One is deep homology, the finding that dissimilar organs such as the eyes of insects, vertebrates and cephalopod molluscs, long thought to have evolved separately, are contr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
