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Earl Wilbur Sutherland, Jr.
Earl Wilbur Sutherland Jr. (November 19, 1915 – March 9, 1974) was an American pharmacologist and biochemist born in Burlingame, Kansas. Sutherland won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers, namely cyclic adenosine monophosphate, or cyclic AMP. Early life and education Sutherland was born on November 19, 1915, in Burlingame, Kansas. The second youngest of six children, he was raised by his mother, Edith M. Hartshorn, and his father, Earl W. Sutherland.Gale Group (2006)"World of Scientific Discovery on Earl Sutherland". World of Scientific Discovery. Though his father, who was originally from Wisconsin, had attended Grinnell College for two years, he ultimately led an agrarian lifestyle that took him to both New Mexico and Oklahoma before settling down in Burlingame to raise a family. Edith, a Missouri native, had some training in nursing at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burlingame, Kansas
Burlingame is a city in Osage County, Kansas, United States. As of the 2020 census, the population of the city was 971. History Burlingame was originally established as Council City and was a stop on the Santa Fe Trail. The Council City post office was opened on April 30, 1855. The wide brick main street, Santa Fe Avenue, was built wide enough for an oxen team to be able to make a U-turn. The city and post office name was changed from Council City to Burlingame on January 30, 1858, in honor of Anson Burlingame. During the Civil War, the townspeople constructed a stone fort in the town center. Burlingame's Fort was torn down after the war. Geography Burlingame is located on U.S. Route 56, approximately south of Topeka. According to the United States Census Bureau, the city has a total area of , all land. Climate The climate in this area is characterized by hot, humid summers and generally mild to cool winters. According to the Köppen Climate Classification system, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Medicine or Physiology, Chemistry, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2024, 115 Nobel Prizes in Physiology or Medicine have been awarded to 229 laureates, 216 men and 13 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucida ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basketball
Basketball is a team sport in which two teams, most commonly of five players each, opposing one another on a rectangular Basketball court, court, compete with the primary objective of #Shooting, shooting a basketball (ball), basketball (approximately in diameter) through the defender's Basket (basketball), hoop (a basket in diameter mounted high to a Backboard (basketball), backboard at each end of the court), while preventing the opposing team from shooting through their own hoop. A Field goal (basketball), field goal is worth two points, unless made from behind the 3 point line, three-point line, when it is worth three. After a foul, timed play stops and the player fouled or designated to shoot a technical foul is given one, two or three one-point free throws. The team with the most points at the end of the game wins, but if regulation play expires with the score tied, an additional period of play (Overtime (sports), overtime) is mandated. Players advance the ball by boun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tennis
Tennis is a List of racket sports, racket sport that is played either individually against a single opponent (singles (tennis), singles) or between two teams of two players each (doubles (tennis), doubles). Each player uses a tennis racket strung with a cord to strike a hollow rubber tennis ball, ball covered with felt over or around a net and into the opponent's tennis court, court. The object is to manoeuvre the ball in such a way that the opponent is not able to play a valid return. If a player is unable to return the ball successfully, the opponent scores a Point (tennis), point. Playable at all levels of society and at all ages, tennis can be played by anyone who can hold a racket, including Wheelchair tennis, wheelchair users. The original forms of tennis developed in France during the late Middle Ages. The modern form of tennis originated in Birmingham, England, in the late 19th century as lawn tennis. It had close connections to various field (lawn) games such as croqu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Missouri
Missouri (''see #Etymology and pronunciation, pronunciation'') is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. At 1.5 billion years old, the St. Francois Mountains are among the oldest in the world. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the List of U.S. states and territories by population, 19th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Missouri, Kansas City, Springfield, Missouri, Springfield, and Columbia, Missouri, Columbia. The Cap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oklahoma
Oklahoma ( ; Choctaw language, Choctaw: , ) is a landlocked U.S. state, state in the South Central United States, South Central region of the United States. It borders Texas to the south and west, Kansas to the north, Missouri to the northeast, Arkansas to the east, New Mexico to the west, and Colorado to the northwest. Partially in the western extreme of the Upland South, it is the List of U.S. states and territories by area, 20th-most extensive and the List of U.S. states and territories by population, 28th-most populous of the 50 United States. Its residents are known as Oklahomans and its capital and largest city is Oklahoma City. The state's name is derived from the Choctaw language, Choctaw words , 'people' and , which translates as 'red'. Oklahoma is also known informally by its List of U.S. state and territory nicknames, nickname, "The Sooner State", in reference to the Sooners, American pioneer, American settlers who staked their claims in formerly American Indian-o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Mexico
New Mexico is a state in the Southwestern United States, Southwestern region of the United States. It is one of the Mountain States of the southern Rocky Mountains, sharing the Four Corners region with Utah, Colorado, and Arizona. It also borders the state of Texas to the east and southeast, Oklahoma to the northeast, and shares Mexico-United States border, an international border with the Mexican states of Chihuahua (state), Chihuahua and Sonora to the south. New Mexico's largest city is Albuquerque, and its List of capitals in the United States, state capital is Santa Fe, New Mexico, Santa Fe, the oldest state capital in the U.S., founded in 1610 as the government seat of Santa Fe de Nuevo México, Nuevo México in New Spain. It also has the highest elevation of any state capital, at . New Mexico is the List of U.S. states and territories by area, fifth-largest of the fifty states by area, but with just over 2.1 million residents, ranks List of U.S. states and terri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grinnell College
Grinnell College ( ) is a Private college, private Liberal arts colleges in the United States, liberal arts college in Grinnell, Iowa, United States. It was founded in 1846 when a group of Congregationalism in the United States, Congregationalists from New England established Iowa College. It has an Curriculum, open curriculum, which means students need not follow a prescribed list of classes. The college's 120-acre campus includes several listings on the National Register of Historic Places. History In 1843, eleven Congregational ministers, all of whom trained at Andover Theological Seminary in Massachusetts, set out to preach on the frontier. The group also sought to establish a college, which followed in 1846, when they collectively established Iowa College in Davenport, Iowa, Davenport. The first 25 years of Grinnell's history saw a change in name and location. In Davenport, the college had Abolitionism, advocated against slavery and Temperance movement, saloons, leadin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wisconsin
Wisconsin ( ) is a U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest of the United States. It borders Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake Michigan to the east, Michigan to the northeast, and Lake Superior to the north. With a population of about 6 million and an area of about 65,500 square miles, Wisconsin is the List of U.S. states and territories by population, 20th-largest state by population and the List of U.S. states and territories by area, 23rd-largest by area. It has List of counties in Wisconsin, 72 counties. Its List of municipalities in Wisconsin by population, most populous city is Milwaukee; its List of capitals in the United States, capital and second-most populous city is Madison, Wisconsin, Madison. Other urban areas include Green Bay, Wisconsin, Green Bay, Kenosha, Wisconsin, Kenosha, Racine, Wisconsin, Racine, Eau Claire, Wisconsin, Eau Claire, and the Fox Cities. Geography of Wiscon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kansas
Kansas ( ) is a landlocked U.S. state, state in the Midwestern United States, Midwestern region of the United States. It borders Nebraska to the north; Missouri to the east; Oklahoma to the south; and Colorado to the west. Kansas is named after the Kansas River, in turn named after the Kaw people, Kansa people. Its List of capitals in the United States, capital is Topeka, Kansas, Topeka, and its List of cities in Kansas, most populous city is Wichita, Kansas, Wichita; however, the largest urban area is the bi-state Kansas City metropolitan area split between Kansas and Missouri. For thousands of years, what is now Kansas was home to numerous and diverse Plains Indians, Indigenous tribes. The first settlement of non-indigenous people in Kansas occurred in 1827 at Fort Leavenworth. The pace of settlement accelerated in the 1850s, in the midst of political wars over the Slavery in the United States, slavery debate. When it was officially opened to settlement by the U.S. governm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Adenosine Monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. History Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). Synthesis The synthesis of cAMP is stimulated by trophic hormones that bind to receptors on the cell surface. cAMP levels reach maximal levels within minutes and decrease gradually over an hour in cultured cells. Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second Messengers
Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form of cell signaling, encompassing both first messengers and second messengers, are classified as autocrine, juxtacrine, paracrine, and endocrine depending on the range of the signal.) Second messengers trigger physiological changes at cellular level such as proliferation, differentiation, migration, survival, apoptosis and depolarization. They are one of the triggers of intracellular signal transduction cascades. Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. First messengers are extracellular factors, often hormones or neurotransmitters, such as epinephrine, growth hormone, and serotonin. Because peptide hormones and neurotransmitters typically are biochemically hydrophilic molecules, these first messe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
