ERMAP
Erythroid membrane-associated protein is a protein that in humans is responsible for the Scianna antigen system, Scianna blood group system, and is encoded by the ''ERMAP'' gene. References Further reading * * * * * * * * * * * External links Scianna blood group system in the BGMUT blood group antigen gene mutation database {{gene-1-stub Blood antigen systems ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Scianna Antigen System
The Scianna blood antigen system consists of seven antigens. These include two high frequency antigens Sc1 and Sc3, and two low frequency antigens Sc2 and Sc4. The very rare null phenotype is characterised by the absence of Sc1, Sc2 and Sc3. The antigens are caused by changes in the erythroid membrane associated protein (ERMAP). History This blood group system was discovered in 1962 when a high frequency antigen was detected in a young woman (Ms. Scianna) who had experienced several late pregnancy losses due to Haemolytic disease of the fetus and newborn, haemolytic disease of the fetus. References {{Transfusion medicine Antigens Blood Cell biology ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid resid ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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BGMUT
The BGMUT (Blood Group antigen gene MUTation) Database documents allelic variations in the genes encoding for human blood group systems. It was set up in 1999 through an initiative of the Human Genome Variation Society ( HGVS). Since 2006, it has been a part of the dbRBC (database Red Blood Cells) resource of NCBI at the NIH. In addition to being a repository of the genetic variations of the blood group antigen-encoding genes, the database also provides information on the blood group systems, the genes that encode them, the serological phenotypes associated with the alleles of the genes, etc. Information on genetic variations in some non-human orthologous genes is also provided. References External links * {{cite web , url = https://www.ncbi.nlm.nih.gov/gv/rbc/ , title = Blood Group Antigen Gene Mutation Database (BGMUT) , vauthors=Blumenfeld OO, Patnaik SK , date = , work = dbRBC , publisher = NCBI at the NIH The National Institutes of Health, commonly referred to as ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |