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Désiré Collen
Désiré, Baron Collen (born in Sint-Truiden, Belgium, 21 June 1943) is a Belgian physician, chemist, biotechnology entrepreneur and life science investor. He made several discoveries in thrombosis, haemostasis and vascular biology in many of which serendipity played a significant role. His main achievement has been his role in the development of tissue-type plasminogen activator (t-PA) from a laboratory concept to a life-saving drug for dissolving blood clots causing acute myocardial infarction or acute ischemic stroke. Recombinant t-PA was produced and marketed by Genentech Inc as Activase and by Boehringer Ingelheim GmbH as Actilyse, and is considered biotechnology's first life saving drug.Delude C. Clot-Busters !! - Discovery of thrombolitic therapy for treating heart attack and stroke. Breakthrough in Bioscience. FASEB 2004, 6. In 2008 Collen reached the mandatory retirement age of 65 years as Professor of the Faculty of Medicine at KU Leuven (Belgium), where he served as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sint-Truiden
Sint-Truiden (; french: link=no, Saint-Trond ; li, Sintruin ) is a city and municipality located in the province of Limburg, Flemish Region, Belgium, and has over 41,500 inhabitants, which makes it one of the largest cities in Limburg. The municipality includes the former communes (now ''deelgemeenten'') of Aalst, Brustem, Duras, Engelmanshoven, Gelinden, Gorsem, Groot-Gelmen, Halmaal, Kerkom-bij-Sint-Truiden, Melveren, Metsteren, Ordingen, Runkelen, Velm, Wilderen, and Zepperen. The city is in the centre of Belgium's fruit-producing region, ''Haspengouw'' ( Hesbaye), and is renowned for its pears, apples (Jonagold), and sweet cherries. History Origins and Golden Age The municipality formed around an abbey founded by St. Trudo, a Frankish nobleman, in the 7th century. Legend has it that as a boy, Trudo was playing while building a small church with some rocks. When a woman scornfully kicked over the rocks she was struck by sudden blindness. Trudo cured her fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recombinant Protein
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome. Recombinant DNA is the general name for a piece of DNA that has been created by combining at least two fragments from two different sources. Recombinant DNA is possible because DNA molecules from all organisms share the same chemical structure, and differ only in the nucleotide sequence within that identical overall structure. Recombinant DNA molecules are sometimes called chimeric DNA, because they can be made of material from two different species, like the mythical chimera. R-DNA technology uses palindromic sequences and leads to the production of sticky and blunt ends. The DNA sequences used in the construction of recombinant DNA molecules can originate from any species. For example, plant DNA may be joined to bact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baron
Baron is a rank of nobility or title of honour, often hereditary, in various European countries, either current or historical. The female equivalent is baroness. Typically, the title denotes an aristocrat who ranks higher than a lord or knight, but lower than a viscount or count. Often, barons hold their fief – their lands and income – directly from the monarch. Barons are less often the vassals of other nobles. In many kingdoms, they were entitled to wear a smaller form of a crown called a '' coronet''. The term originates from the Latin term , via Old French. The use of the title ''baron'' came to England via the Norman Conquest of 1066, then the Normans brought the title to Scotland and Italy. It later spread to Scandinavia and Slavic lands. Etymology The word ''baron'' comes from the Old French , from a Late Latin "man; servant, soldier, mercenary" (so used in Salic law; Alemannic law has in the same sense). The scholar Isidore of Seville in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King Albert II Of Belgium
, house = Belgium , father = Leopold III of Belgium , mother = Astrid of Sweden , birth_date = , birth_place = Stuyvenberg Castle, Laeken, Brussels, Belgium , death_date = , death_place = , signature = Albert II of Belgium Signature.svg , religion = Roman Catholicism Albert II, ; nl, Albert Felix Humbert Theodoor Christiaan Eugène Marie, ; german: Albrecht Felix Humbert Theodor Christian Eugen Maria, (born 6 June 1934) is a member of the Belgian royal family who reigned as King of the Belgians from 9 August 1993 to 21 July 2013. Albert II is the son of King Leopold III and the last living child of Queen Astrid, born a princess of Sweden. He is the younger brother of the late Grand Duchess Joséphine-Charlotte of Luxembourg and King Baudouin, whom he succeeded upon Baudouin's death in 1993. He married Donna Paola Ruffo di Calabria (now Queen Paola), with whom he had three children. Albert's eldest son, Philippe, is the current King of the Belgians. On ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmin
Plasmin is an important enzyme () present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the ''PLG'' gene. Function Plasmin is a serine protease that acts to dissolve fibrin blood clots. Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system, and weakens the wall of the Graafian follicle, leading to ovulation. Plasmin is also integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs to the family of serine proteases. Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation. Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ocriplasmin
Ocriplasmin (trade name Jetrea) is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface. It is used for treatment of symptomatic vitreomacular adhesion, for which it received FDA approval on 17 October 2012. It works by dissolving the proteins that link the vitreous to the macula, resulting in posterior detachment of the vitreous from the retina. Structure Ocriplasmin is an injectable drug that is "a truncated form of the human serine protease plasmin." The protease plasmin still retains its enzymatic properties. Ocriplasmin consists of two polypeptide chains that are linked by disulfide bonds. Additionally, the longer peptide chain has four disulfide bonds. Ocriplasmin is only moderately stable when injected, and this is due to autolytic degradation. Mechanism of action Ocriplasmin can degrade various structural proteins, including laminin and fibronectin, which are localized in the vitreoretinal surface. Here, these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Staphylokinase
Staphylokinase (SAK; also known as staphylococcal fibrinolysin or Müller's factor) is a protein produced by ''Staphylococcus aureus''. It contains 136 amino acid residues and has a molecular mass of 15kDa. Synthesis of staphylokinase occurs in late exponential phase. It is similar to streptokinase. Staphylokinase is positively regulated by the "agr" gene regulator. It activates plasminogen to form plasmin, which digests fibrin clots. This disrupts the fibrin meshwork which forms to keep infections localized. Staphylokinase interacts with plasminogen to form a 1:1 complex that exposes the active site of the plasminogen molecule. The plasmin Sak complex is neutralized by α2- antiplasmin in plasma in the absence of fibrin, resulting in lysis. However, in the presence of fibrin, the inhibition is delayed, creating a unique mechanism for fibrin selectivity in plasma. Staphylokinase also cleaves IgG and complement component C3b, inhibiting phagocytosis. Structure The full length ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reed Elsevier
RELX plc (pronounced "Rel-ex") is a British multinational information and analytics company headquartered in London, England. Its businesses provide scientific, technical and medical information and analytics; legal information and analytics; decision-making tools; and organise exhibitions. It operates in 40 countries and serves customers in over 180 nations. It was previously known as Reed Elsevier, and came into being in 1993 as a result of the merger of Reed International, a British trade book and magazine publisher, and Elsevier, a Netherlands-based scientific publisher. The company is publicly listed, with shares traded on the London Stock Exchange, Amsterdam Stock Exchange and New York Stock Exchange (ticker symbols: London: REL, Amsterdam: REN, New York: RELX). The company is one of the constituents of the FTSE 100 Index, Financial Times Global 500 and Euronext 100 Index. History The company, which was previously known as Reed Elsevier, came into being in 1993, as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PMID (identifier)
PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the database as part of the Entrez system of information retrieval. From 1971 to 1997, online access to the MEDLINE database had been primarily through institutional facilities, such as university libraries. PubMed, first released in January 1996, ushered in the era of private, free, home- and office-based MEDLINE searching. The PubMed system was offered free to the public starting in June 1997. Content In addition to MEDLINE, PubMed provides access to: * older references from the print version of '' Index Medicus'', back to 1951 and earlier * references to some journals before they were indexed in Index Medicus and MEDLINE, for instance ''Science'', '' BMJ'', and '' Annals of Surgery'' * very recent entries to records for an article ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doi (identifier)
A digital object identifier (DOI) is a persistent identifier or handle used to uniquely identify various objects, standardized by the International Organization for Standardization (ISO). DOIs are an implementation of the Handle System; they also fit within the URI system (Uniform Resource Identifier). They are widely used to identify academic, professional, and government information, such as journal articles, research reports, data sets, and official publications. DOIs have also been used to identify other types of information resources, such as commercial videos. A DOI aims to resolve to its target, the information object to which the DOI refers. This is achieved by binding the DOI to metadata about the object, such as a URL where the object is located. Thus, by being actionable and interoperable, a DOI differs from ISBNs or ISRCs which are identifiers only. The DOI system uses the indecs Content Model for representing metadata. The DOI for a document remains fixed ov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
KU Leuven
KU Leuven (or Katholieke Universiteit Leuven) is a Catholic research university in the city of Leuven, Belgium. It conducts teaching, research, and services in computer science, engineering, natural sciences, theology, humanities, medicine, law, canon law, business, and social sciences. In addition to its main campus in Leuven, it has satellite campuses in Kortrijk, Antwerp, Ghent, Bruges, Ostend, Geel, Diepenbeek, Aalst, Sint-Katelijne-Waver, and in Belgium's capital Brussels. KU Leuven is the largest university in Belgium and the Low Countries. In 2017–18, more than 58,000 students were enrolled. Its primary language of instruction is Dutch, although several programs are taught in English, particularly graduate and postgraduate degrees. KU Leuven consistently ranks among the top 100 universities in the world by major ranking tables. As of 2021, it ranks 42nd in the '' Times Higher Education'' rankings, 70th according QS World University Rankings, 87th according to th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actilyse
Alteplase (t-PA), a biosynthetic form of human tissue-type plasminogen activator (t-PA), is a thrombolytic medication, used to treat acute ischemic stroke, acute ST elevation myocardial infarction, ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. It is given by injection into a vein or artery. Alteplase is the same as the normal Tissue plasminogen activator, human plasminogen activator produced in Endothelium, vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis. Medical uses Alteplase is mainly used to treat acute ischemic stroke, acute myocardial infarction, acute massive pulmonary embolism, and blocked catheters. Similar to other Thrombolysis, thrombolytic drugs, alteplase is used to Thrombolysis, dissolve clots to restore tissue perfusion, but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
