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Duck Embryo Vaccine
Purified duck embryo vaccine (PDEV) was the first vaccine developed for human use in treating pre- and postexposure to the rabies virus. It was developed in 1957 and was made of dried, killed rabies virus. Vaccination with PDEV involved a series of intradermal injections over several days. The World Health Organization still includes PDEV in its list of recommended vaccines for treatment of rabies virus exposure. However, newer vaccines are more commonly used. These include the human diploid cell vaccine (HDCV) first introduced in 1978; purified chicken embryo cell vaccine (PCECV), developed in 1984; and a purified Vero cell rabies vaccine (PVCRV) developed in 1986.Centers for Disease Control Morbidity and Mortality Weekly Report. Atlanta. January 08, 1999 /48(RR-1);1-21 See also * List of vaccine ingredients * List of vaccine topics * Reverse vaccinology * Virosome * Immunity References External links * WHO Vaccine preventable diseases and immunizationThe History of Vacci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic (to pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabies Virus
Rabies virus, scientific name ''Rabies lyssavirus'', is a neurotropic virus that causes rabies in humans and animals. Rabies transmission can occur through the saliva of animals and less commonly through contact with human saliva. ''Rabies lyssavirus'', like many rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laboratory it has been found that birds can be infected, as well as cell cultures from mammals, birds, reptiles and insects. Rabies is reported in more than 150 countries on all continents, with the exclusion of Antarctica. The main burden of disease is reported in Asia and Africa, but some cases have been reported also in Europe in the past 10 years, especially in returning travellers. ''Rabies lyssavirus'' has a cylindrical morphology and is a member of the ''Lyssavirus'' genus of the ''Rhabdoviridae'' family. These viruses are enveloped and have a single stranded RNA genome with negative-se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Health Organization
The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level of health". Headquartered in Geneva, Switzerland, it has six regional offices and 150 field offices worldwide. The WHO was established on 7 April 1948. The first meeting of the World Health Assembly (WHA), the agency's governing body, took place on 24 July of that year. The WHO incorporated the assets, personnel, and duties of the League of Nations' Health Organization and the , including the International Classification of Diseases (ICD). Its work began in earnest in 1951 after a significant infusion of financial and technical resources. The WHO's mandate seeks and includes: working worldwide to promote health, keeping the world safe, and serve the vulnerable. It advocates that a billion more people should have: universal health care ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Diploid Cell Vaccine
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically modern hum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Vaccine Ingredients ...
This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients and production in other nations are substantially the same. Also listed are substances used in the manufacturing process. See also * Excipient * Vaccine types * Vaccination schedule * Adjuvant * Preservative * Cell culture * Growth medium References The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines. {{reflist Excipients Excipients An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Vaccine Topics
This is a list of vaccine-related topics. A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters. Human vaccines Viral diseases Bacterial diseases Vaccines under research Viral diseases * Adenovirus vaccine * COVID-19 vaccine ( Part of today's pandemic since 2019) * Coxsackie B virus vaccine * Cytomegalovirus vaccine * Chikungunya vaccine * Eastern Equine encephalitis virus vaccine for humans * Enterovirus 71 vaccine * Epstein–Barr vaccine * H5N1 vaccine * Hepatitis C vaccine * HIV vaccine * HTLV-1 T-lymphotropic leukemia vaccine for humans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse Vaccinology
Reverse vaccinology is an improvement of vaccinology that employs bioinformatics and reverse pharmacology practices, pioneered by Rino Rappuoli and first used against Serogroup B meningococcus. Since then, it has been used on several other bacterial vaccines. Computational approach The basic idea behind reverse vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes. Some traits that the genes are monitored for, may indicate antigenicity and include genes that code for proteins with extracellular localization, signal peptides & B cell epitopes. Those genes are filtered for desirable attributes that would make good vaccine targets such as outer membrane proteins. Once the candidates are identified, they are produced synthetically and are screened in animal models of the infection. History After Craig Venter published the genome of the first free-living organism in 1995, the genomes of other microorganisms became more read ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virosome
A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. Viruses are infectious agents that can replicate in their host organism, however virosomes do not replicate. The properties that virosomes share with viruses are based on their structure; virosomes are essentially safely modified viral envelopes that contain the phospholipid membrane and surface glycoproteins. As a drug or vaccine delivery mechanism they are biologically compatible with many host organisms and are also biodegradable. The use of reconstituted virally derived proteins in the formation of the virosome allows for the utilization of what would otherwise be the immunogenic properties of a live-attenuated virus, but is instead a safely killed virus. A safely killed virus can serve as a promising vector because it won't cause infection and the viral str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunity (medical)
In biology, immunity is the capability of multicellular organisms to resist harmful microorganisms. Immunity involves both specific and nonspecific components. The nonspecific components act as barriers or eliminators of a wide range of pathogens irrespective of their antigenic make-up. Other components of the immune system adapt themselves to each new disease encountered and can generate pathogen-specific immunity. Immunity is a complex biological system that can recognize and tolerate whatever belongs to the self, and to recognize and reject what is foreign (non-self). Innate and adaptive Innate Immunity First off, the immune system is a system in the body of animals that enables animals to avoid or limit many infections caused by pathogens. Pathogens are disease causing agents, causing a wide range of illnesses. As for Diseases it's when structure of an organism is negatively affected other than external injury. Both diseases and pathogens affect the immune system causing ill ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Of Physicians Of Philadelphia
The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries. The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places. Current programs The College remains a private membership organization of physicians, whose ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccination
Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating the body's adaptive immunity, they help prevent sickness from an infectious disease. When a sufficiently large percentage of a population has been vaccinated, herd immunity results. Herd immunity protects those who may be immunocompromised and cannot get a vaccine because even a weakened version would harm them. The effectiveness of vaccination has been widely studied and verified. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the elimination of diseases such as polio and tetanus from much of the world. However, some diseases, such as measles outbreaks in America, have seen rising cases due to relativel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virology
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, their interaction with host organism physiology and immunity, the diseases they cause, the techniques to isolate and culture them, and their use in research and therapy. The identification of the causative agent of tobacco mosaic disease (TMV) as a novel pathogen by Martinus Beijerinck (1898) is now acknowledged as being the official beginning of the field of virology as a discipline distinct from bacteriology. He realized the source was neither a bacterial nor a fungal infection, but something completely different. Beijerinck used the word "virus" to describe the mysterious agent in his 'contagium vivum fluidum' ('contagious living fluid'). Rosalind Franklin proposed the full structure of the tobacco mosaic virus in 1955. Virology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
