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Dopesick (book)
''Dopesick: Dealers, Doctors, and the Drug Company that Addicted America'' is a 2018 non-fiction book by American author Beth Macy. The book covers the origin and evolution of the opioid epidemic in the United States beginning primarily with the 1996 release of the drug OxyContin, and examines its effects on small town America and the Appalachian region in particular. It was well received by critics and won the ''Los Angeles Times'' Book Prize for Science and Technology. In 2021, the book was adapted into a Hulu miniseries starring Michael Keaton. Background Author Beth Macy worked as a journalist for the Roanoke, Virginia-based newspaper ''The Roanoke Times'' from 1989 until 2014. In 2012, following the completion of her first book, ''Factory Man'', Macy was assigned a story by the newspaper to report on a local teen who had died of a heroin overdose. Macy's subsequent reporting on the topic prompted her to suggest heroin and opioid abuse as the subject of her next book. Her N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beth Macy
Beth Macy (born ) is an American journalist and non-fiction writer. She is the author of four published books, including national bestsellers ''Factory Man'' (2014) and ''Dopesick'' (2018). Early life The daughter of a factory worker, Sarah Macy Slack, and a housepainter father, Macy grew up in Urbana, Ohio. She was the first in her family to attend college, receiving a bachelor's degree in journalism from Bowling Green State University in 1986. She earned a master's degree in creative writing from Hollins University in 1993. Career Macy was a reporter for ''The Roanoke Times'' from 1989 to 2014. She writes essays and op-eds for ''The New York Times'' as well as magazines, radio and online journals. In 2010, she was awarded the Nieman Fellowship, Nieman Fellowship for Journalism by Harvard University. Her 2018 book, ''Dopesick'', was shortlisted for the Andrew Carnegie Medals for Excellence in Fiction and Nonfiction, 2019 Andrew Carnegie Medal for Excellence in Nonfiction. Tele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayer
Bayer AG (English: , commonly pronounced ; ) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include: pharmaceuticals, consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the EURO STOXX 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer (1825–1880) and dyer Friedrich Weskott (1821–1876). The company was established as a dyestuffs producer, but the versatility of aniline chemistry led Bayer to expand its business into other areas. In 1899, Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. Aspirin is on the World Health Organization's List of Essential Medicines. In 2021, it was the 34th most commonly prescribed medication in the United State ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Southern United States
The Southern United States (sometimes Dixie, also referred to as the Southern States, the American South, the Southland, Dixieland, or simply the South) is List of regions of the United States, census regions defined by the United States Census Bureau. It is between the Atlantic Ocean and the Western United States, with the Midwestern United States, Midwestern and Northeastern United States to its north and the Gulf of Mexico and Mexico to its south. Historically, the South was defined as all states south of the 18th-century Mason–Dixon line, the Ohio River, and the Parallel 36°30′ north, 36°30′ parallel.The South . ''Britannica''. Retrieved June 5, 2021. Within the South are different subregions such as the Southeastern United States, Southeast, South Central United States, South Central, Upland South, Upper South, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buprenorphine
Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant. For opioid use disorder, the patient must have moderate opioid withdrawal symptoms before buprenorphine can be administered under direct observation of a health-care provider. In the United States, the combination formulation of buprenorphine/naloxone (Suboxone) is usually prescribed to discourage misuse by injection. However, more recently the efficacy of naloxone in preventing misuse has been brought into question, and preparations of buprenorphine combined with naloxone could potentially be less safe than buprenorphine alone. Maximum pain relief is generally within an hour with effects up to 24 hours. Buprenorphine affects different types of opioid receptors in diffe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute On Drug Abuse
The National Institute on Drug Abuse (NIDA) is a United States federal government research institute whose mission is to "advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual and public health." The institute has conducted an in-depth study of addiction according to its biological, behavioral and social components. It has also supported many treatments such as nicotine patches and gums, and performed research into AIDS and other drug-related diseases. Its monopoly on the supply of research-grade marijuana has proved controversial. History NIDA's roots can be traced back to 1935, when a research facility (named the Addiction Research Center in 1948) was established in Lexington, Kentucky as part of a USPHS hospital. The Drug Abuse Warning Network (DAWN) and National Household Survey on Drug Abuse (NHSDA) were created in 1972. In 1974 NIDA was established as part of the Alcohol, Drug Abuse, and Mental Health Adm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nora Volkow
Nora D. Volkow (born 27 March 1956) is a Mexican-American psychiatrist. She is currently the director of the National Institute on Drug Abuse (NIDA), which is part of the National Institutes of Health (NIH). Early life and education Born in Mexico City to a Jewish family, Volkow is a daughter of Esteban Volkov, whose mother Zinaida Volkova was the eldest daughter of the Jewish-Russian communist revolutionary Leon Trotsky. Volkow and her three sisters grew up in Coyoacán in the house where Trotsky was killed (now the Leon Trotsky Museum). Volkow was educated at the Modern American School, in Mexico City, and graduated M.D. from the National University of Mexico, before her postdoctoral training in Psychiatry at New York University. In 2014, Volkow participated in an event organized by The Moth at a World Science Festival, where scientists, writers and artists told stories of their personal relationships with science. During this time, she discussed her family history and ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioid Agonist Therapy
Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with opioid use disorder (OUD). In the case of methadone maintenance treatment (MMT), methadone is used to treat dependence on heroin or other opioids, and is administered on an ongoing basis. The benefits of this treatment include a more manageable withdrawal experience, cognitive improvement, and lower HIV transmission. The length of OAT varies from one individual to another based on their physiology, environmental surroundings, and quality of life. The term medication for Opioid Use Disorder (MOUD) is used to describe medication including methadone and buprenorphine, which are used to treat patients with OUD. Terminology Other terms that appear in the professional and popular literature include opioid replacement therapy, medication-assisted treatment (MAT) and medications for opioid use disorder (MOUD). Biological understanding An opioid is considered a ligand, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disposable And Discretionary Income
Disposable income is total personal income minus current taxes on income. In national accounting, personal income minus personal current taxes equals disposable personal income or household disposable income. Subtracting personal outlays (which includes the major category of personal r privateconsumption expenditure) yields personal (or, private) savings, hence the income left after paying away all the taxes is referred to as disposable income. Restated, consumption expenditure plus savings equals disposable income after accounting for transfers such as payments to children in school or elderly parents' living and care arrangements. The marginal propensity to consume (MPC) is the fraction of a change in disposable income that is consumed. For example, if disposable income rises by $100, and $65 of that $100 is consumed, the MPC is 65%. Restated, the marginal propensity to save is 35%. For the purposes of calculating the amount of income subject to garnishments, United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beer
Beer is an alcoholic beverage produced by the brewing and fermentation of starches from cereal grain—most commonly malted barley, although wheat, maize (corn), rice, and oats are also used. The grain is mashed to convert starch in the grain to sugars, which dissolve in water to form wort. Fermentation of the wort by yeast produces ethanol and carbonation in the beer. Beer is one of the oldest and most widely consumed alcoholic drinks in the world, and one of the most popular of all drinks. Most modern beer is brewed with hops, which add bitterness and other flavours and act as a natural preservative and stabilising agent. Other flavouring agents, such as gruit, herbs, or fruits, may be included or used instead of hops. In commercial brewing, natural carbonation is often replaced with forced carbonation. Beer is distributed in bottles and cans, and is commonly available on draught in pubs and bars. The brewing industry is a global business, consisting of several ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Illegal Drug Trade
The illegal drug trade, drug trafficking, or narcotrafficking is a global black market dedicated to the cultivation, manufacture, distribution and sale of drug prohibition, prohibited drugs. Most jurisdictions prohibitionism, prohibit trade, except under license, of many types of drugs through the use of drug prohibition laws. The think tank Global Financial Integrity's ''Transnational Crime and the Developing World'' report estimates the size of the global illicit drug market between US$426 and US$652billion in 2014, which is equal to the UK's national debt alone. With a Gross world product, world GDP of US$78 trillion in the same year, the illegal drug trade may be estimated as nearly 1% of total global trade. Consumption of illegal drugs is widespread globally, and it remains very difficult for local authorities to reduce the rates of drug consumption. History Prior to the 20th century, governments rarely made a major effort to proscribe recreational drug use, though sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Narcotic
The term narcotic (, from ancient Greek ναρκῶ ''narkō'', "I make numb") originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiates and opioids, commonly morphine and heroin, as well as derivatives of many of the compounds found within raw opium latex. The primary three are morphine, codeine, and thebaine (while thebaine itself is only very mildly psychoactive, it is a crucial precursor in the vast majority of semi-synthetic opioids, such as oxycodone or hydrocodone). Legally speaking, the term "narcotic" may be imprecisely defined and typically has negative connotations. When used in a legal context in the U.S., a narcotic drug is totally prohibited, such as heroin, or one that is used in violation of legal regulation (in this word sense, equal to any controlled substance or illicit drug). In the medical community, the term is more precisely defined and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Addiction
Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences. Repetitive drug use can alter brain function in synapses similar to natural rewards like food or falling in love in ways that perpetuate craving and weakens self-control for people with pre-existing vulnerabilities. This phenomenon – drugs reshaping brain function – has led to an understanding of addiction as a brain disorder with a complex variety of psychosocial as well as neurobiological factors that are implicated in the development of addiction. While mice given cocaine showed the compulsive and involuntary nature of addiction, for humans this is more complex, related to behavior or personality traits. Classic signs of addiction include compulsive engagement in rewarding stimuli, ''preoccupation'' with substances or behavior, and continued use des ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
