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Disease Resistance
Disease resistance is the ability to prevent or reduce the presence of diseases in otherwise susceptible hosts. It can arise from genetic or environmental factors, such as incomplete penetrance. Disease tolerance is different as it is the ability of a host to limit the impact of disease on host health. In crops this includes plant disease resistance and can follow a gene-for-gene relationship. Genetic Factors Incomplete Penetrance An example of a genetic factor causing disease resistance is incomplete penetrance. Incomplete penetrance is the result of a genetic mutation not fully manifesting as the associated trait or disease. In the combined case of sickle cell anemia and malaria, individuals with one normal allele and one sickle cell allele, (heterozygous HbAS), are largely healthy due to incomplete penetrance. They do not experience the effects of having sickle cell anemia, (due to the incomplete nature of the mutation), and gain resistance to malaria. This is due to th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sickle Cell Genetic Resistance To Malaria
A sickle, bagging hook, reaping-hook or grasshook is a single-handed agricultural tool designed with variously curved blades and typically used for harvesting or reaping grain crops, or cutting succulent forage chiefly for feeding livestock. Falx was a synonym, but was later used to mean any of a number of tools that had a curved blade that was sharp on the inside edge. Since the beginning of the Iron Age The Iron Age () is the final epoch of the three historical Metal Ages, after the Chalcolithic and Bronze Age. It has also been considered as the final age of the three-age division starting with prehistory (before recorded history) and progre ... hundreds of region-specific variants of the sickle have evolved, initially of iron and later steel. This great diversity of sickle types across many cultures can be divided into smooth or serrated blades, both of which can be used for cutting either green grass or mature cereals using slightly different techniques. The serrated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disease
A disease is a particular abnormal condition that adversely affects the structure or function (biology), function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergy, allergies, and autoimmune disorders. In humans, ''disease'' is often used more broadly to refer to any condition that causes pain, Abnormality (behavior), dysfunction, distress (medicine), distress, social problems, or death to the person affected, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injury in humans, injuries, disability, disabilities, Disorder (medicine) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Susceptible Individual
In epidemiology a susceptible individual (sometimes known simply as a susceptible) is a member of a population who is at risk of becoming infected by a disease. Susceptible individuals Susceptibles have been exposed to neither the wild strain of the disease nor a vaccination against it, and thus have not developed immunity. Those individuals who have antibodies against an antigen associated with a particular infectious disease will not be susceptible, even if they did not produce the antibody themselves (for example, infants younger than six months who still have maternal antibodies passed through the placenta and from the colostrum, and adults who have had a recent injection of antibodies). However, these individuals soon return to the susceptible state as the antibodies are broken down. Some individuals may have a natural resistance to a particular infectious disease. However, except in some special cases such as malaria, these individuals make up such a small proportion of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penetrance
Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (genotype) that also expresses an associated trait (phenotype). In medical genetics, the penetrance of a disease-causing mutation is the proportion of individuals with the mutation that exhibit clinical Symptom, symptoms among all individuals with such mutation. For example: If a mutation in the gene responsible for a particular autosomal dominant disorder has 95% penetrance, then 95% of those with the mutation will go on to develop the disease, showing its phenotype, whereas 5% will not. Penetrance only refers to whether an individual with a specific genotype exhibits any phenotypic signs or symptoms, and is not to be confused with Expressivity (genetics), variable expressivity which is to what extent or degree the symptoms for said disease are shown (the expression of the phenotypic trait). Meaning that, even if the same disease-causing mutation affects separate individ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disease Tolerance
Tolerance to infection, or disease tolerance, is a mechanism that host organisms can use to fight parasites or pathogens that attack the host. Tolerance is not equivalent to resistance. Disease resistance is the host trait that prevents infection or reduces the number of pathogens and parasites within or on a host. Tolerance to infection can be illustrated via comparing host performance versus increasing load. This is a reaction norm in which host performance is regressed against increasing disease burden. The slope of the reaction norm defines the degree of tolerance. High tolerance is indicated as a flat slope, i.e., host performance is not influenced by increasing burden. Steep downward slope indicates low tolerance in which host performance is strongly reduced with increasing burden. An upward slope indicates overcompensation in which a host increases its performance with increasing burden. Genetic variation in tolerance and its correlation with resistance, can be quantified usi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Disease Resistance
Plant disease resistance protects plants from pathogens in two ways: by pre-formed structures and chemicals, and by infection-induced responses of the immune system. Relative to a susceptible plant, disease resistance is the reduction of pathogen growth on or in the plant (and hence a reduction of disease), while the term disease tolerance describes plants that exhibit little disease damage despite substantial pathogen levels. Disease outcome is determined by the three-way interaction of the pathogen, the plant, and the environmental conditions (an interaction known as the disease triangle). Defense-activating compounds can move cell-to-cell and systematically through the plant's vascular system. However, plants do not have circulating immune cells, so most cell types exhibit a broad suite of antimicrobial defenses. Although obvious ''qualitative'' differences in disease resistance can be observed when multiple specimens are compared (allowing classification as "resistant" or "su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene-for-gene Relationship
The gene-for-gene relationship is a concept in plant pathology that plants and their diseases each have single genes that interact with each other during an infection. It was proposed by Harold Henry Flor who was working with rust (''Melampsora lini'') of flax ('' Linum usitatissimum''). Flor showed that the inheritance of both resistance in the host and parasite ability to cause disease is controlled by pairs of matching genes. One is a plant gene called the resistance (''R'') gene. The other is a parasite gene called the avirulence (''Avr'') gene. Plants producing a specific R gene product are resistant towards a pathogen that produces the corresponding ''Avr'' gene product. Gene-for-gene relationships are a widespread and very important aspect of plant disease resistance. Another example can be seen with '' Lactuca serriola'' versus '' Bremia lactucae''. Clayton Oscar Person was the first scientist to study plant pathosystem ratios rather than genetics ratios in host-paras ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features Peer review, peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2022 ''Journal Citation Reports'' (with an ascribed impact factor of 50.5), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in the autumn of 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander MacMillan (publisher), Alexander MacMillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Breeding For Disease Resistance
Plant disease resistance protects plants from pathogens in two ways: by pre-formed structures and chemicals, and by infection-induced responses of the immune system. Relative to a susceptible plant, disease resistance is the reduction of pathogen growth on or in the plant (and hence a reduction of disease), while the term disease tolerance describes plants that exhibit little disease damage despite substantial pathogen levels. Disease outcome is determined by the three-way interaction of the pathogen, the plant, and the environmental conditions (an interaction known as the disease triangle). Defense-activating compounds can move cell-to-cell and systematically through the plant's vascular system. However, plants do not have circulating immune cells, so most cell types exhibit a broad suite of antimicrobial defenses. Although obvious ''qualitative'' differences in disease resistance can be observed when multiple specimens are compared (allowing classification as "resistant" or "sus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene-for-gene Relationship
The gene-for-gene relationship is a concept in plant pathology that plants and their diseases each have single genes that interact with each other during an infection. It was proposed by Harold Henry Flor who was working with rust (''Melampsora lini'') of flax ('' Linum usitatissimum''). Flor showed that the inheritance of both resistance in the host and parasite ability to cause disease is controlled by pairs of matching genes. One is a plant gene called the resistance (''R'') gene. The other is a parasite gene called the avirulence (''Avr'') gene. Plants producing a specific R gene product are resistant towards a pathogen that produces the corresponding ''Avr'' gene product. Gene-for-gene relationships are a widespread and very important aspect of plant disease resistance. Another example can be seen with '' Lactuca serriola'' versus '' Bremia lactucae''. Clayton Oscar Person was the first scientist to study plant pathosystem ratios rather than genetics ratios in host-paras ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, Epileptic seizure, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected ''Anopheles'' mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial Immunity (medical), resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquitoes themselves are harmed by malaria, causing reduced lifespans in those infected by it. Malaria is caused by protozoa, single-celled microorganisms of the genus ''Plasmodium''. It is spread exclusively through bites of infected female ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
