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Disc1
Disrupted in schizophrenia 1 is a protein that in humans is encoded by the ''DISC1'' gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level, the DISC1 interactome gene set was associated with schizophrenia, s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DISC2
In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia. It is antisense to the DISC1 gene and may regulate the expression of DISC1. DISC2 may also contribute to other psychiatric disorders. See also * Long noncoding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ... References Further reading * * * * * * * * Non-coding RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Motif
In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a common three-dimensional structure that appears in a variety of different, evolutionarily unrelated molecules. A structural motif does not have to be associated with a sequence motif; it can be represented by different and completely unrelated sequences in different proteins or RNA. In nucleic acids Depending upon the sequence and other conditions, nucleic acids can form a variety of structural motifs which is thought to have biological significance. ;Stem-loop: Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop. The resulting structure is a key building block of many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coiled Coil
A coiled coil is a structural motif in proteins in which two to seven alpha-helices are coiled together like the strands of a rope. ( Dimers and trimers are the most common types.) They have been found in roughly 5-10% of proteins and have a variety of functions. They are one of the most widespread motifs found in protein-protein interactions. To aid protein study, several tools have been developed to predict coiled-coils in protein structures. Many coiled coil-type proteins are involved in important biological functions, such as the regulation of gene expression — e.g., transcription factors. Notable examples are the oncoproteins c-Fos and c-Jun, as well as the muscle protein tropomyosin. Discovery The possibility of coiled coils for α-keratin was initially somewhat controversial. Linus Pauling and Francis Crick independently came to the conclusion that this was possible at about the same time. In the summer of 1952, Pauling visited the laboratory in England where C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canis Familiaris
The dog (''Canis familiaris'' or ''Canis lupus familiaris'') is a Domestication of vertebrates, domesticated descendant of the gray wolf. Also called the domestic dog, it was Selective breeding, selectively bred from a population of wolves during the Late Pleistocene by hunter-gatherers. The dog was the first species to be domesticated by humans, over 14,000 years ago and before the History of agriculture, development of agriculture. Due to their long association with humans, dogs have gained the ability to thrive on a starch-rich diet that would be inadequate for other Canidae, canids. Dogs have been bred for desired behaviors, sensory capabilities, and physical attributes. Dog breeds vary widely in shape, size, and color. They have the same number of bones (with the exception of the tail), powerful jaws that house around 42 teeth, and well-developed Dog sense of smell, senses of smell, hearing, and sight. Compared to humans, dogs possess a superior sense of smell and heari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bos Taurus
Cattle (''Bos taurus'') are large, domesticated, bovid ungulates widely kept as livestock. They are prominent modern members of the subfamily Bovinae and the most widespread species of the genus '' Bos''. Mature female cattle are called cows and mature male cattle are bulls. Young female cattle are called heifers, young male cattle are oxen or bullocks, and castrated male cattle are known as steers. Cattle are commonly raised for meat, for dairy products, and for leather. As draft animals, they pull carts and farm implements. Cattle are considered sacred animals within Hinduism, and it is illegal to kill them in some Indian states. Small breeds such as the miniature Zebu are kept as pets. Taurine cattle are widely distributed across Europe and temperate areas of Asia, the Americas, and Australia. Zebus are found mainly in India and tropical areas of Asia, America, and Australia. Sanga cattle are found primarily in sub-Saharan Africa. These types, sometimes cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Takifugu Rubripes
''Takifugu rubripes'', commonly known as the Japanese puffer, Japanese pufferfish, Tiger puffer, or torafugu (), is a pufferfish in the genus '' Takifugu''. It is distinguished by a very small genome that has been fully sequenced because of its use as a model species and is in widespread use as a reference in genomics. Taxonomy and etymology The species is often referred to in the genomics literature as ''Fugu rubripes''. The genus ''Fugu'' is a synonym of the currently preferred '' Takifugu''. ''Takifugu'' is Japanese for puffer and ''rubripes'' comes from the Latin ''ruber'' and ''pēs'' meaning ruddy foot. Distribution and habitat The species is known from the Sea of Japan, East China Sea and Yellow Sea north to southern Sakhalin, at depths of . It is a demersal species. Spawning occurs in estuaries; young fish can tolerate a wide range of salinities and will remain in river mouths and lagoons, maturing for one year before migrating permanently to the open ocean. Genome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Danio Rerio
The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a " tropical fish" although it is both tropical and subtropical). The zebrafish is an important and widely used vertebrate model organism in scientific research, particularly developmental biology, but also gene function, oncology, teratology, and drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with '' Danio aesculapii''. Zebrafish are also closely related to the genus '' Devario'', as demonstrated by a phylogenetic tree of close species. Distr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rattus Norvegicus
''Rattus'' is a genus of muroid rodents, all typically called rats. However, the term rat can also be applied to rodent species outside of this genus. Species and description The best-known ''Rattus'' species are the black rat (''R. rattus'') and the brown rat (''R. norvegicus''). The group is generally known as the Old World rats or true rats and originated in Asia. Rats are bigger than most Old World mice, which are their relatives, but seldom weigh over in the wild. Taxonomy of ''Rattus'' The genus ''Rattus'' is a member of the giant subfamily Murinae. Several other murine genera are sometimes considered part of ''Rattus'': ''Lenothrix'', '' Anonymomys'', '' Sundamys'', '' Kadarsanomys'', '' Diplothrix'', '' Margaretamys'', '' Lenomys'', '' Komodomys'', '' Palawanomys'', '' Bunomys'', ''Nesoromys'', ''Stenomys'', '' Taeromys'', '' Paruromys'', '' Abditomys'', '' Tryphomys'', '' Limnomys'', '' Tarsomys'', '' Bullimus'', '' Apomys'', '' Millardia'', '' Srilankamys'', '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mus Musculus
The house mouse (''Mus musculus'') is a small mammal of the rodent family Muridae, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus ''Mus (genus), Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the synanthropic populations near human activity. The house mouse has been domestication, domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was Whole genome sequencing, sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually Agouti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macaca Mulatta
The macaques () constitute a genus (''Macaca'') of sociality, gregarious Old World monkeys of the subfamily Cercopithecinae. The 23 species of macaques inhabit species distribution, ranges throughout Asia, North Africa, and Europe (in Barbary macaques in Gibraltar, Gibraltar). Macaques are principally frugivore, frugivorous (preferring fruit), although their diet also includes seeds, leaves, flowers, and tree bark. Some species such as the long-tailed macaque (''M. fascicularis''; also called the crab-eating macaque) will supplement their diets with small amounts of meat from shellfish, insects, and small mammals. On average, a southern pig-tailed macaque (''M. nemestrina'') in Malaysia eats about 70 large rats each year. All macaque social groups are arranged around dominant matriarchy, matriarchs. Macaques are found in a variety of habitats throughout the Asian continent and are highly adaptation, adaptable. Certain species are synanthrope, synanthropic, having learned to live ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pan Troglodytes
The chimpanzee (; ''Pan troglodytes''), also simply known as the chimp, is a species of great ape native to the forests and savannahs of tropical Africa. It has four confirmed subspecies and a fifth proposed one. When its close relative the bonobo was more commonly known as the pygmy chimpanzee, this species was often called the common chimpanzee or the robust chimpanzee. The chimpanzee and the bonobo are the only species in the genus ''Pan''. Evidence from fossils and DNA sequencing shows that ''Pan'' is a sister taxon to the human lineage and is thus humans' closest living relative. The chimpanzee is covered in coarse black hair but has a bare face, fingers, toes, palms of the hands, and soles of the feet. It is larger and more robust than the bonobo, weighing for males and for females and standing . The chimpanzee lives in groups that range in size from 15 to 150 members, although individuals travel and forage in much smaller groups during the day. The species lives in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
