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Diphepanol
Diphepanol is a cough medicine, cough suppressant (antitussive). Synthesis Ex 1: The α-keto bromination of propiophenone [93-55-0] (1) gives 2-bromopropiophenone [2114-00-3] (2). Displacement of the halogen and hence amination with piperidine [110-89-4] gave alpha-PiperidinopropiophenoneCID:458526(3). and addition of phenyl Grignard reagent to give the benzhydrol product, and hence Dihepanol (4). See also *Diphenidol *Clofedanol References Antitussives 1-Piperidinyl compounds {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diphepanol Synthesis
Diphepanol is a cough suppressant (antitussive). Synthesis Ex 1: The α-keto bromination of propiophenone Propiophenone (shorthand: benzoylethane or BzEt) is an aryl ketone. It is a colorless, sweet-smelling liquid that is insoluble in water, but miscible with organic solvents. It is used in the preparation of other compounds. Production Propiophenon ... 3-55-0(1) gives 2-bromopropiophenone 114-00-3(2). Displacement of the halogen and hence amination with piperidine 10-89-4gave alpha-PiperidinopropiophenoneCID:458526(3). and addition of phenyl Grignard reagent to give the benzhydrol product, and hence Dihepanol (4). See also * Diphenidol * Clofedanol References Antitussives 1-Piperidinyl compounds {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Propiophenone
Propiophenone (shorthand: benzoylethane or BzEt) is an aryl ketone. It is a colorless, sweet-smelling liquid that is insoluble in water, but miscible with organic solvents. It is used in the preparation of other compounds. Production Propiophenone can be prepared by Friedel–Crafts reaction of propanoyl chloride and benzene. It is also prepared commercially by ketonization of benzoic acid and propionic acid over calcium acetate and alumina at 450–550 °C: :C6H5CO2H + CH3CH2CO2H → C6H5C(O)CH2CH3 + CO2 + H2O Ludwig Claisen discovered that Alpha and beta carbon, α-methoxystyrene forms this compound when heated for an hour at 300 °C (65% yield). Uses file:Phenmetrazine.svg, 120px, left, Phenmetrazine, derived from propiophenone, is an appetite suppressant. It is an intermediate in the synthesis of the pharmaceuticals phenmetrazine and propoxyphen. Other drugs made from propiophenone include the following: PDM-35, Eprazinone, Methcathinone (leading to ephedrine), Tri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cough Medicine
Cold medicines are a group of medications taken individually or in combination as a treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract. The term encompasses a broad array of drugs, including analgesics, antihistamines and decongestants, among many others. It also includes drugs which are marketed as cough suppressants or antitussives, but their effectiveness in reducing cough symptoms is unclear or minimal. While they have been used by 10% of American children in any given week, they are not recommended in Canada or the United States in children six years or younger because of lack of evidence showing effect and concerns of harm. Types There are a number of different cough and cold medications, which may be used for various coughing symptoms. The commercially available products may include various combinations of any one or more of the following types of substances: * Mucokinetics, or mucolytics, are a class of drugs which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diphenidol
Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. A series of selective mACh-receptor antagonists based on the diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials. Synthesis Alkylation of 1-Bromo-3-chloropropane 09-70-6(1) with piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clofedanol
Clofedanol (INN) or chlophedianol ( BAN), sold under the brand name Ninjacof among others, is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic, antispasmodic, and antihistamine properties, and may have anticholinergic effects at high doses. Side effects Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, and urticaria. There are potential interactions with other anticholinergics, CNS depressants, and alcohol. Pharmacology Unlike many other antitussive drugs such as dextromethorphan, it binds poorly to the sigma-1 receptor. Society and culture Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process and its safety and efficacy data are limited. It was formerly sold over-the-counter in the United States under the trade name Ulo, as a syrup with a dosage of 25 mg/5 mL. It is now marketed under the brand name of Ninjacof a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antitussives
Cold medicines are a group of medications taken individually or in combination as a treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract. The term encompasses a broad array of drugs, including analgesics, antihistamines and decongestants, among many others. It also includes drugs which are marketed as cough suppressants or antitussives, but their effectiveness in reducing cough symptoms is unclear or minimal. While they have been used by 10% of American children in any given week, they are not recommended in Canada or the United States in children six years or younger because of lack of evidence showing effect and concerns of harm. Types There are a number of different cough and cold medications, which may be used for various coughing symptoms. The commercially available products may include various combinations of any one or more of the following types of substances: * Mucokinetics, or mucolytics, are a class of drugs which aid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
