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Dinogunellin
Dinogunellins are unusual toxic phospholipids found in the roe of some fishes, and is one of the best studied ichthyotoxin. These phospholipids could be found as a complex with non-toxic proteins like in the cabezon toxin or in the lipostichaerin. Occurrence Dinogunellins were detected in the mature roe of four fishes: the cabezon or marbled sculpin ''Scorpaenichthys marmoratus,'' the blennies ''Stichaeus grigorjewi'' and ''Stichaeus nozawae,'' Kamiya H, Hatano M, and Hashimoto Y. 1997. Screening of Icthyootoxin. Bulletin of the Japanese Society of Scientific Fisheries. 43(12):1461-1465. and the killifish ''Fundulus heteroclitus.'' The presence of dinogunellins has been discarded in the roe of the carp ''Cyprinus carpio'', the sculpin ''Hemitripterus villosus'', the blenny '' Lumpenus fowleri'', and the lamprey '' Lapetra japonica''. Structure Dinogunellins are unusual phospholipids having a nucleotide instead of the typical glycerol in their structure. They consist of an a ...
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Cabezon (fish)
The cabezon (''Scorpaenichthys marmoratus'') is a large species of sculpin native to the Pacific coast of North America. Although the genus name translates literally as "scorpion fish", true scorpionfish (such as lionfish) belong to the related family Scorpaenidae. The cabezon is the only known member of its genus. Taxonomy The cabezon was first formally described as ''Hemitripterus marmoratus'' in 1854 by the American physician and ichthyologist William Orville Ayres with its type locality given as California. Both Ayres and the French biologist Charles Frédéric Girard published the specific name ''marmoratus'' for this taxon in 1854, Ayres published his name on 8 September in ''The Pacific'', a San Francisco based journal in which the California Academy of Sciences published its meeting repotrs, and the name was published once mor on 22 September in the ''Proceedings of the California Academy of Sciences''. Girard's name was deemed to have been published on 6 October and ...
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Scorpaenichthys Marmoratus
The cabezon (''Scorpaenichthys marmoratus'') is a large species of sculpin native to the Pacific coast of North America. Although the genus name translates literally as "scorpion fish", true scorpionfish (such as lionfish) belong to the related family Scorpaenidae. The cabezon is the only known member of its genus. Taxonomy The cabezon was first formally described as ''Hemitripterus marmoratus'' in 1854 by the American physician and ichthyologist William Orville Ayres with its type locality given as California. Both Ayres and the French biologist Charles Frédéric Girard published the specific name ''marmoratus'' for this taxon in 1854, Ayres published his name on 8 September in ''The Pacific'', a San Francisco based journal in which the California Academy of Sciences published its meeting repotrs, and the name was published once mor on 22 September in the '' Proceedings of the California Academy of Sciences''. Girard's name was deemed to have been published on 6 Octob ...
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Adenine
Adenine () (symbol A or Ade) is a nucleobase (a purine derivative). It is one of the four nucleobases in the nucleic acid of DNA that are represented by the letters G–C–A–T. The three others are guanine, cytosine and thymine. Its derivatives have a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD), flavin adenine dinucleotide (FAD) and Coenzyme A. It also has functions in protein synthesis and as a chemical component of DNA and RNA. The shape of adenine is complementary to either thymine in DNA or uracil in RNA. The adjacent image shows pure adenine, as an independent molecule. When connected into DNA, a covalent bond is formed between deoxyribose sugar and the bottom left nitrogen (thereby removing the existing hydrogen atom). The remaining structure is called an ''adenine residue'', as part of a larger molecule. Adenosine is adenine ...
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Pubchem
PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH). PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be freely downloaded via FTP. PubChem contains multiple substance descriptions and small molecules with fewer than 100 atoms and 1,000 bonds. More than 80 database vendors contribute to the growing PubChem database. History PubChem was released in 2004 as a component of the Molecular Libraries Program (MLP) of the NIH. As of November 2015, PubChem contains more than 150 million depositor-provided substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results (from over 1 million assay experiments performed on mo ...
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Diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin with loss of the normal stretchiness of the skin and irritable behaviour. This can progress to decreased urination, loss of skin color, a fast heart rate, and a decrease in responsiveness as it becomes more severe. Loose but non-watery stools in babies who are exclusively breastfed, however, are normal. The most common cause is an infection of the intestines due to either a virus, bacterium, or parasite—a condition also known as gastroenteritis. These infections are often acquired from food or water that has been contaminated by feces, or directly from another person who is infected. The three types of diarrhea are: short duration watery diarrhea, short duration bloody diarrhea, and persistent diarrhea (lasting more than two wee ...
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Nausea
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the throat. Over 30 definitions of nausea were proposed in a 2011 book on the topic. Nausea is a non-specific symptom, which means that it has many possible causes. Some common causes of nausea are gastroenteritis and other gastrointestinal disorders, food poisoning, motion sickness, dizziness, migraine, fainting, low blood sugar, anxiety, and lack of sleep. Nausea is a side effect of many medications including chemotherapy, or morning sickness in early pregnancy. Nausea may also be caused by disgust and depression. Medications taken to prevent and treat nausea and vomiting are called antiemetics. The most commonly prescribed antiemetics in the US are promethazine, metoclopramide, and the newer ondansetron. The word nausea ...
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Diaphoresis
Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals. Two types of sweat glands can be found in humans: eccrine glands and apocrine glands. The eccrine sweat glands are distributed over much of the body and are responsible for secreting the watery, brackish sweat most often triggered by excessive body temperature. The apocrine sweat glands are restricted to the armpits and a few other areas of the body and produce an odorless, oily, opaque secretion which then gains its characteristic odor from bacterial decomposition. In humans, sweating is primarily a means of thermoregulation, which is achieved by the water-rich secretion of the eccrine glands. Maximum sweat rates of an adult can be up to 2–4 liters per hour or 10–14 liters per day (10–15 g/min·m2), but is less in children prior to puberty. Evaporation of sweat from the skin surface has a cooling effect due to evaporative cooling. Hence, in hot wea ...
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Stearidonic Acid
Stearidonic acid (SDA: C18 H28 O2; 18: 4, n-3) is an ω-3 fatty acid, sometimes called moroctic acid. It is biosynthesized from alpha-linolenic acid (ALA: C18H30O2; 18:3, n-3) by the enzyme delta-6-desaturase, that removes two hydrogen (H) atoms from a fatty acid, creating a carbon/carbon double bonding, via an oxygen requiring unsaturation. SDA also act as precursor for the rapid synthesis of longer chain fatty acids, called ''N''-acylethanolamine (NAEs), involved in many important biological processes. Natural sources of this fatty acid are the seed oils of hemp, blackcurrant, corn gromwell, and ''Echium plantagineum'', and the cyanobacterium ''Spirulina''. SDA can also be synthesized in a lab. A GMO soybean source is approved by the European Food Safety Authority. See also *List of omega-3 fatty acids Omega-3 fatty acids, also called ω−3 fatty acids or ''n''−3 fatty acids, are polyunsaturated fatty acids (PUFAs). Omega−3 fatty acids are important for normal ...
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Eicosapentaenoic Acid
Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). It also has the trivial name timnodonic acid. In chemical structure, EPA is a carboxylic acid with a 20- carbon chain and five '' cis'' double bonds; the first double bond is located at the third carbon from the omega end. EPA is a polyunsaturated fatty acid (PUFA) that acts as a precursor for prostaglandin-3 (which inhibits platelet aggregation), thromboxane-3, and leukotriene-5 eicosanoids. EPA is both a precursor and the hydrolytic breakdown product of eicosapentaenoyl ethanolamide (EPEA: C22 H35 NO2; 20:5,n-3). Although studies of fish oil supplements, which contain both docosahexaenoic acid (DHA) and EPA, have failed to support claims of preventing heart attacks or strokes, a recent multi-year study of Vascepa (ethyl eicosapentaenoate, the ethyl ester of the free fatty acid), a prescription drug containing only EPA, was s ...
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Fatty Acid
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, from 4 to 28. Fatty acids are a major component of the lipids (up to 70% by weight) in some species such as microalgae but in some other organisms are not found in their standalone form, but instead exist as three main classes of esters: triglycerides, phospholipids, and cholesteryl esters. In any of these forms, fatty acids are both important dietary sources of fuel for animals and important structural components for cells. History The concept of fatty acid (''acide gras'') was introduced in 1813 by Michel Eugène Chevreul, though he initially used some variant terms: ''graisse acide'' and ''acide huileux'' ("acid fat" and "oily acid"). Types of fatty acids Fatty acids are classified in many ways: by length, by saturation vs unsat ...
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