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Dimerization Of Catharanthine And Vindoline
Catharanthine and vindoline are terpenoid indole alkaloids naturally produced within the Madagascar periwinkle plant (''Catharanthus roseus'') whose dimerization produces the anti-cancer drugs vinblastine and vincristine. The precursor of catharanthine and vindoline is strictosidine, the common precursor of all indole alkaloids. Misra, N., Luthra, R., Singh, K. L., & Kumar, S. (1999). Recent advances in biosynthesis of alkaloids. Comprehensive Natural Products Chemistry, 25–59. https://doi.org/10.1016/b978-0-08-091283-7.00127-2 The localization of catharanthine and vindoline within the plant tissue has been heavily studied in recent years with conflicting results. The dimerization of catharanthine and vindoline to form vinblastine and vincristine is catalyzed by a peroxidase and a reductase, and includes several intermediate compounds.Li, C., Wood, J. C., Vu, A. H., Hamilton, J. P., Rodriguez Lopez, C. E., Payne, R. M., Serna Guerrero, D. A., Gase, K., Yamamoto, K., Vaillan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Close-up View Of Catharanthus Roseus (known As Nayantara In Bengali) In West Bengal, India, Photographed By Yogabrata Chakraborty, On October 2, 2021
A close-up or closeup in filmmaking, television production, still photography, and the comic strip medium is a type of shot that tightly frames a person or object. Close-ups are one of the standard shots used regularly with medium and long shots (cinematic techniques). Close-ups display the most detail, but they do not include the broader scene. Moving toward or away from a close-up is a common type of zooming. A close up is taken from head to neck, giving the viewer a detailed view of the subject's face. History Most early filmmakers, such as Thomas Edison, Auguste and Louis Lumière and Georges Méliès, tended not to use close-ups and preferred to frame their subjects in long shots, similar to the stage. Film historians disagree as to the filmmaker who first used a close-up. One of the best claims is for George Albert Smith in Hove, who used medium close-ups in films as early as 1898 and by 1900 was incorporating extreme close-ups in films such as ''As Seen Through a Tele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apocynaceae
Apocynaceae (, from '' Apocynum'', Greek for "dog-away") is a family of flowering plants that includes trees, shrubs, herbs, stem succulents, and vines, commonly known as the dogbane family, because some taxa were used as dog poison. Notable members of the family include oleander, dogbanes, milkweeds, and periwinkles. The family is native to the European, Asian, African, Australian, and American tropics or subtropics, with some temperate members as well. The former family Asclepiadaceae (now known as Asclepiadoideae) is considered a subfamily of Apocynaceae and contains 348 genera. A list of Apocynaceae genera may be found here. Many species are tall trees found in tropical forests, but some grow in tropical dry ( xeric) environments. Also perennial herbs from temperate zones occur. Many of these plants have milky latex, and many species are poisonous if ingested, the family being rich in genera containing alkaloids and cardiac glycosides, those containing the latter oft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthase
In biochemistry, a synthase is an enzyme that catalyses a synthesis process. Note that, originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates. However, the Joint Commission on Biochemical Nomenclature (JCBN) dictates that 'synthase' can be used with any enzyme that catalyzes synthesis (whether or not it uses nucleoside triphosphates), whereas 'synthetase' is to be used synonymously with ' ligase'. Examples * ATP synthase * Citrate synthase * Tryptophan synthase * Pseudouridine synthase * Fatty acid synthase Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the ''FASN'' gene. Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two ide ... * Cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anhydrovinblastine
Vinorelbine, sold under the brand name Navelbine among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer and non-small cell lung cancer. It is given by injection into a vein or by mouth. Common side effects include bone marrow suppression, pain at the site of injection, vomiting, feeling tired, numbness, and diarrhea. Other serious side effects include shortness of breath. Use during pregnancy may harm the baby. Vinorelbine is in the vinca alkaloid family of medications. It is believed to work by disrupting the normal function of microtubules and thereby stopping cell division. Vinorelbine was approved for medical use in the United States in 1994. It is on the World Health Organization's List of Essential Medicines. Medical uses Vinorelbine is approved for the treatment of non-small-cell lung cancer. It is used off-label for other cancers such as metastatic breast cancer and for aggressive fibromatosis (desmoid tumor). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
