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Derek George Smyth
Derek George Smyth, (24 April 1927 – 28 October 2024) was a British biochemist who specialised in peptide structure and function. In 2002, he was admitted as a Fellow of the Royal Society of Chemistry. Life and career Smyth started working at the National Institute for Medical Research in 1963. He was Head of the Laboratory of Peptide Chemistry in Mill Hill, London from 1972 to 1992. He had worked previously with Professor Joseph Fruton, Head of the Biochemistry Department at Yale University, where he gained experience in protein and peptide chemistry and in 1960 transferred to Rockefeller University in New York City where, in the laboratory of Stanford Moore and William Howard Stein, he reinvestigated and established the amino acid sequence of pancreatic ribonuclease. His major contribution came from studies of β-lipotropin, now recognised as a component of the pro-opiomelanocortin locus. After retiring from NIMR, Smyth continued his research at the Institute for Mol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kingston Upon Thames
Kingston upon Thames, colloquially known as Kingston, is a town in the Royal Borough of Kingston upon Thames, south-west London, England. It is situated on the River Thames, south-west of Charing Cross. It is an ancient market town, notable as the place where some History of Anglo-Saxon England, Saxon kings were crowned. Historic counties of England, Historically in the county of Surrey, the ancient Kingston upon Thames (parish), parish of Kingston covered both the town itself and a large surrounding area. The town was an ancient borough, having been formally incorporated in 1441, with a long history prior to that as a royal manor. From 1836 until 1965 the town formed the Municipal Borough of Kingston-upon-Thames. From 1893 to 2020 Kingston was the seat of Surrey County Council. The town became part of Greater London in 1965, when the modern borough was also created as one of the 32 London boroughs. Kingston is identified as a metropolitan centre in the London Plan and is one o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United States, and one of the nine colonial colleges chartered before the American Revolution. Yale was established as the Collegiate School in 1701 by Congregationalism in the United States, Congregationalist clergy of the Connecticut Colony. Originally restricted to instructing ministers in theology and sacred languages, the school's curriculum expanded, incorporating humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first Doctor of Philosophy, PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew rapidly after 1890 due to the expansion of the physical campus and its scientif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and anesthetic effects. Analgesic choice is also determined by the type of pain: For neuropathic pain, recent research has suggested that classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants may be considered as an alternative. Various analgesics, such as many NSAIDs, are available over the counter in most countries, whereas various others are prescription drugs owing to the substantial risks and high chances of overdose, misuse, and addiction in the absence of medical supervision. Etymology The word ''analgesic'' derive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endorphin
Endorphins (contracted from endogenous morphine) are peptides produced in the brain that block the perception of pain and increase feelings of wellbeing. They are produced and stored in the pituitary gland of the brain. Endorphins are endogenous painkillers often produced in the brain and adrenal medulla during physical exercise or orgasm and inhibit pain, muscle cramps, and relieve stress. History Opioid peptides in the brain were first discovered in 1973 by investigators at the University of Aberdeen, John Hughes (neuroscientist), John Hughes and Hans Kosterlitz. They isolated "enkephalins" (from the Greek language, Greek ) from pig brain, identified as Met-enkephalin and Leu-enkephalin. This came after the discovery of a receptor that was proposed to produce the pain-relieving analgesic effects of morphine and other opioids, which led Kosterlitz and Hughes to their discovery of the endogenous opioid ligands. Research during this time was focused on the search for a painki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipotropin
Lipotropin is the name for two hormones produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which is then cleaved again to form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH). β-Lipotropin β-Lipotropin is a 90-amino acid polypeptide that is the carboxy-terminal fragment of POMC. It was initially reported to stimulate melanocytes to produce melanin. It was also reported to perform lipid-mobilizing functions such as lipolysis and steroidogenesis. However, no subsequent studies have been published that support these early findings and no receptor has been identified for β-lipotropin. β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-endorphin is the predominant opioid of the anterior human and rat pituitary gland. Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South China Morning Post
The ''South China Morning Post'' (''SCMP''), with its Sunday edition, the ''Sunday Morning Post'', is a Hong Kong-based English-language newspaper owned by Alibaba Group. Founded in 1903 by Tse Tsan-tai and Alfred Cunningham, it has remained Hong Kong's newspaper of record since British colonial rule. Editor-in-chief Tammy Tam succeeded Wang Xiangwei in 2016. The ''SCMP'' prints paper editions in Hong Kong and operates an online news website that is blocked in mainland China. The newspaper's circulation has been relatively stable for years—the average daily circulation stood at 100,000 in 2016. In a 2019 survey by the Chinese University of Hong Kong, the ''SCMP'' was regarded relatively as the most credible paid newspaper in Hong Kong. The ''SCMP'' was owned by Rupert Murdoch's News Corporation from 1986 until it was acquired by Malaysian real estate tycoon Robert Kuok in 1993. On 5 April 2016, Alibaba Group acquired the media properties of the SCMP Group, including ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dial Press
The Dial Press is a publishing house founded in 1923 by Lincoln MacVeagh. The Dial Press shared a building with ''The Dial'' and Scofield Thayer worked with both. The first imprint was issued in 1924. Authors included Elizabeth Bowen, W. R. Burnett and Glenway Wescott, Frank Yerby, James Baldwin, Roy Campbell (poet), Roy Campbell, Susan Berman, Herbert Gold, Thomas Berger (novelist), Thomas Berger, Vance Bourjaily, Judith Rossner, and Norman Mailer. History In 1963, Dell Publishing, Dell Publishing Company acquired 60 percent of The Dial Press's stock but the Press remained an independent subsidiary. It was jointly owned by Richard Baron (1923–2021) and Dell Publishing; E. L. Doctorow was editor-in-chief. In 1969 The Dial Press became wholly owned by Dell Publishing Company. In 1976 Doubleday (publisher), Doubleday bought Dell Publishing and the children's division of The Dial Press (Dial Books for Young Readers) was sold to E. P. Dutton. The children's division of Dial Pres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proopiomelanocortin
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is Protein biosynthesis, synthesized in Corticotropic cell, corticotrophs of the anterior pituitary from the 267-amino-acid-long Precursor polypeptide, polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation (biology), translation. POMC is part of the central melanocortin system. Function POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicle (biology), vesicles that are released from the cells by exocytosis in response to appropriate stimulation: * Melanocyte-stimulating hormone, α-MSH produced by neurons in the ventromedial nucleus has important roles in the regulation of appetite (POMC neuron stimulation results in Hunger (motivational state), satiety.) and Human sexual activity, sexual behavior, while α-MSH secreted from the pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipotropin
Lipotropin is the name for two hormones produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which is then cleaved again to form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH). β-Lipotropin β-Lipotropin is a 90-amino acid polypeptide that is the carboxy-terminal fragment of POMC. It was initially reported to stimulate melanocytes to produce melanin. It was also reported to perform lipid-mobilizing functions such as lipolysis and steroidogenesis. However, no subsequent studies have been published that support these early findings and no receptor has been identified for β-lipotropin. β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-endorphin is the predominant opioid of the anterior human and rat pituitary gland. Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
McGraw-Hill
McGraw Hill is an American education science company that provides educational content, software, and services for students and educators across various levels—from K-12 to higher education and professional settings. They produce textbooks, digital learning tools, and adaptive technology to enhance learning experiences and outcomes. It is one of the "big three" educational publishers along with Houghton Mifflin Harcourt and Pearson Education. McGraw Hill also publishes reference and trade publications for the medical, business, and engineering professions. Formerly a division of The McGraw Hill Companies (later renamed McGraw Hill Financial, now S&P Global), McGraw Hill Education was divested and acquired by Apollo Global Management in March 2013 for $2.4 billion in cash. McGraw Hill was sold in 2021 to Platinum Equity for $4.5 billion. History McGraw Hill was founded in 1888, when James H. McGraw, co-founder of McGraw Hill, purchased the ''American Journal of Railway ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saunders (imprint)
Saunders is an American academic publisher based in the United States. It is currently an imprint of Elsevier. Formerly independent, the W. B. Saunders company was acquired by CBS in 1968, who added it to their publishing division Holt, Rinehart & Winston. When CBS left the publishing field in 1986, it sold the academic publishing units to Harcourt Brace Jovanovich. Harcourt was acquired by Reed Elsevier in 2001. . Northern Illinois University Libraries. Retrieved May 2, 2015. W. B. Saunders published the Kinsey Reports
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Pancreatic Ribonuclease
Pancreatic ribonuclease family (, ''RNase'', ''RNase I'', ''RNase A'', ''pancreatic RNase'', ''ribonuclease I'', ''endoribonuclease I'', ''ribonucleic phosphatase'', ''alkaline ribonuclease'', ''ribonuclease'', ''gene S glycoproteins'', ''Ceratitis capitata alkaline ribonuclease'', ''SLSG glycoproteins'', ''gene S locus-specific glycoproteins'', ''S-genotype-assocd. glycoproteins'', ''ribonucleate 3'-pyrimidino-oligonucleotidohydrolase'') is a superfamily of pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the RNA helix by complexing with single-stranded RNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
