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David Van Essen
David C. Van Essen (born September 14, 1945) is an American neuroscientist specializing in neurobiology and studies the structure, function, development, connectivity and evolution of the cerebral cortex of humans and nonhuman relatives. After over two decades of teaching at the Washington University School of Medicine, Washington University in St. Louis School of Medicine, he currently serves as an Alumni Endowed Professor of Neuroscience and maintains an active laboratory. Van Essen has held numerous positions, including Editor-in-Chief of the Journal of Neuroscience, Secretary of the Society for Neuroscience, and the President of the Society for Neuroscience from 2006 to 2007. Additionally, Van Essen has received numerous awards for his efforts in education and science, including the Krieg Cortical Discoverer Award from the Cajal Club in 2002, the Peter Raven Lifetime Achievement Award from St. Louis Academy of Science in 2007, and the Second Century Award in 2015 and the Distingui ...
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Neuroscientist
A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, Biological neural network, neural circuits, and glial cells and especially their Behavior, behavioral, Biology, biological, and psychological aspect in health and disease. Neuroscientists generally work as researchers within a college, university, government agency, or private Private industry, industry setting. In research-oriented careers, neuroscientists typically spend their time designing and carrying out scientific experiments that contribute to the understanding of the nervous system and its function. They can engage in basic or applied research. Basic research seeks to add information to our current understanding of the nervous system, whereas applied research seeks to address a specific problem, such as developing a treatment for a neurological disorder. ...
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Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for ...
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Harvard University Alumni
The list of Harvard University people includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see notable non-graduate alumni of Harvard. For a list of Harvard's presidents, see President of Harvard University. Eight Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ...
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California Institute Of Technology Alumni
California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territories of the United States by population, most populous U.S. state and the List of U.S. states and territories by area, 3rd largest by area. It is also the most populated Administrative division, subnational entity in North America and the 34th most populous in the world. The Greater Los Angeles area and the San Francisco Bay Area are the nation's second and fifth most populous Statistical area (United States), urban regions respectively, with the former having more than 18.7million residents and the latter having over 9.6million. Sacramento, California, Sacramento is the state's capital, while Los Angeles is the List of largest California cities by population, most populous city in the state and the List of United States cities by population, ...
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1945 Births
1945 marked the end of World War II and the fall of Nazi Germany and the Empire of Japan. It is also the only year in which Nuclear weapon, nuclear weapons Atomic bombings of Hiroshima and Nagasaki, have been used in combat. Events Below, the events of World War II have the "WWII" prefix. January * January 1 – WWII: ** Nazi Germany, Germany begins Operation Bodenplatte, an attempt by the ''Luftwaffe'' to cripple Allies of World War II, Allied air forces in the Low Countries. ** Chenogne massacre: German prisoners are allegedly killed by American forces near the village of Chenogne, Belgium. * January 6 – WWII: A German offensive recaptures Esztergom, Kingdom of Hungary (1920–1946), Hungary from the Russians. * January 12 – WWII: The Soviet Union begins the Vistula–Oder Offensive in Eastern Europe, against the German Army (Wehrmacht), German Army. * January 13 – WWII: The Soviet Union begins the East Prussian Offensive, to eliminate German forces in East Pruss ...
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Basal Ganglia Circuits
The basal ganglia (BG), or basal nuclei, are a group of subcortical nuclei, of varied origin, in the brains of vertebrates. In humans, and some primates, there are some differences, mainly in the division of the globus pallidus into an external and internal region, and in the division of the striatum. The basal ganglia are situated at the base of the forebrain and top of the midbrain. Basal ganglia are strongly interconnected with the cerebral cortex, thalamus, and brainstem, as well as several other brain areas. The basal ganglia are associated with a variety of functions, including control of voluntary motor movements, procedural learning, habit learning, conditional learning, eye movements, cognition, and emotion. The main components of the basal ganglia – as defined functionally – are the striatum, consisting of both the dorsal striatum (caudate nucleus and putamen) and the ventral striatum (nucleus accumbens and olfactory tubercle), the globus pallidus, t ...
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Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow ( hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not involve the use of injections, surgery, the ingestion of substances, or exposure to ionizing radiation. This measure is frequently corrupted by noise from various sources; hence, statistical procedures are used to extract the underlying sig ...
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Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example: * Fluorodeoxyglucose ( 18F">sup>18FDG or FDG) is commonly used to detect cancer; * 18Fodium fluoride">sup>18Fodium fluoride (Na18F) is widely used for detecting bone formation; * Oxygen-15 (15O) is sometimes used to measure blood flow. PET is a common imaging technique, a medical scintillography technique used in nuclear medicine. A radiopharmaceutical – a radioisotope attached to a drug – is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is emitted, and when the positron interacts with an or ...
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Neocortex
The neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language. The neocortex is further subdivided into the true isocortex and the proisocortex. In the human brain, the neocortex is the largest part of the cerebral cortex (the outer layer of the cerebrum). The neocortex makes up the largest part of the cerebral cortex, with the allocortex making up the rest. The neocortex is made up of six layers, labelled from the outermost inwards, I to VI. Etymology The term is from ''cortex'', Latin, "bark" or "rind", combined with ''neo-'', Greek, "new". ''Neopallium'' is a similar hybrid, from Latin ''pallium'', "cloak". ''Isocortex'' and ''allocortex'' are hybrids with Greek ''isos'', "same", and ''allos'', "other". Anatomy The neocortex is the most developed in its organis ...
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Macaque
The macaques () constitute a genus (''Macaca'') of gregarious Old World monkeys of the subfamily Cercopithecinae. The 23 species of macaques inhabit ranges throughout Asia, North Africa, and (in one instance) Gibraltar. Macaques are principally frugivorous (preferring fruit), although their diet also includes seeds, leaves, flowers, and tree bark. Some species, such as the crab-eating macaque, subsist on a diet of invertebrates and occasionally small vertebrates. On average, southern pig-tailed macaques in Malaysia eat about 70 large rats each per year. All macaque social groups are matriarchal, arranged around dominant females. Macaques are found in a variety of habitats throughout the Asian continent and are highly adaptable. Certain species have learned to live with humans and have become invasive in some human-settled environments, such as the island of Mauritius and Silver Springs State Park in Florida. Macaques can be a threat to wildlife conservation as well as ...
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Human Connectome Project
The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand Challenges of the NIH's Blueprint for Neuroscience Research. On September 15, 2010, the NIH announced that it would award two grants: $30 million over five years to a consortium led by Washington University in St. Louis and the University of Minnesota, with strong contributions from Oxford University (FMRIB) and $8.5 million over three years to a consortium led by Harvard University, Massachusetts General Hospital and the University of California Los Angeles. The goal of the Human Connectome Project is to build a "network map" (connectome) that will shed light on the anatomical and functional connectivity within the healthy human brain, as well as to produce a body of data that will facilitate research into brain disorders such as dyslex ...
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Neuroinformatics
Neuroinformatics is the field that combines informatics and neuroscience. Neuroinformatics is related with neuroscience data and information processing by artificial neural networks. There are three main directions where neuroinformatics has to be applied: * the development of computational models of the nervous system and neural processes. * the development of tools for analyzing and modeling neuroscience data, * the development of tools and databases for management and sharing of neuroscience data at all levels of analysis, Neuroinformatics is related with philosophy (computational theory of mind), psychology ( information processing theory), computer science (natural computing, bio-inspired computing), among others. Neuroinformatics doesn't deal with matter or energy, so it can be seen as a branch of neurobiology that studies various aspects of nervous systems. The term ''neuroinformatics'' seems to be used synonymously with cognitive informatics, described by '' Journal of Bi ...
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