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David Sachs
David Howard Sachs (born January 10, 1942) is an American immunologist. He is best known for his discovery of MHC class II and for his seminal studies in the fields of transplant immune tolerance and xenotransplantation. Education David Sachs graduated summa cum laude in organic chemistry from Harvard College in 1963, and pursued a master's degree equivalent at the University of Paris on a Fulbright Fellowship in 1964. He then matriculated to Harvard Medical School, where he graduated magna cum laude in 1968. Research As a medical student, Sachs developed an interest in transplantation and joined the laboratory of Drs. Paul Russell and Henry Winn at the Massachusetts General Hospital, where he remained as a surgical resident until 1970. From 1970 to 1972 Sachs fulfilled his military service working in Christian Anfinsen's laboratory at the National Institutes of Health. He remained in Bethesda and joined the National Cancer Institute, where his research led to the discovery ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York, NY
New York, often called New York City (NYC), is the List of United States cities by population, most populous city in the United States, located at the southern tip of New York State on New York Harbor, one of the world's largest natural harbors. The city comprises boroughs of New York City, five boroughs, each coextensive with List of counties in New York, a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global city, global center of financial center, finance and Economy of New York City, commerce, Culture of New York City, culture, high technology, technology, The Entertainment Capital of the World, entertainment and Media in New York City, media, Academy, academics, and List of cities by scientific output, scientific output, the The arts, arts and fashion capital, fashion, and, as hom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xenotransplantation
Xenotransplantation (''xenos-'' from the Greek meaning "foreign" or strange), or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another.Xenotransplantation Definition by the World Health Organization Such cells, tissues or organs are called xenografts or xenotransplants. It is contrasted with (from other individual of same species), syngeneic transplantation or isotransplantation (grafts transplanted between two genetically identical individuals of the same species), and [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard College Alumni
The list of Harvard University alumni includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see the list of Harvard University non-graduate alumni. For a list of Harvard's presidents, see President of Harvard University. Eight Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School Alumni
Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of colonial-era Massachusetts Bay Colony. While never formally affiliated with any denomination, Harvard trained Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston elite. Following the American Civil War, under Harvard president Charles William Eliot's long tenure from 1869 to 1909, Harvard developed multiple professional schools, which transforme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1942 Births
The Uppsala Conflict Data Program project estimates this to be the deadliest year in human history in terms of conflict deaths, placing the death toll at 4.62 million. However, the Correlates of War estimates that the prior year, 1941, was the deadliest such year. Death toll estimates for both 1941 and 1942 range from 2.28 to 7.71 million each. Events Below, the events of World War II have the "WWII" prefix. January * January 1 – WWII: The Declaration by United Nations is signed by China, the United Kingdom, the United States, the Soviet Union, and 22 other nations, in which they agree "not to make any separate peace with the Axis powers". * January 5 – WWII: Two prisoners, British officer Airey Neave and Dutch officer Anthony Luteyn, escape from Colditz Castle in Germany. After travelling for three days, they reach the Swiss border. * January 7 – WWII: ** Battle of Slim River: Japanese forces of the 5th Division (Imperial Japanese Army), 5th Division, sup ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Immunologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Tolerance
Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system's state of unresponsiveness to substances or tissues that would otherwise trigger an immune response. It arises from prior exposure to a specific antigen and contrasts the immune system's conventional role in eliminating foreign antigens. Depending on the site of induction, tolerance is categorized as either central tolerance, occurring in the thymus and bone marrow, or peripheral tolerance, taking place in other tissues and lymph nodes. Although the mechanisms establishing central and peripheral tolerance differ, their outcomes are analogous, ensuring immune system modulation. Immune tolerance is important for normal physiology and homeostasis. Central tolerance is crucial for enabling the immune system to differentiate between self and non-self antigens, thereby preventing autoimmunity. Peripheral tolerance plays a significant role in preventing excessive immune reactions to en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard
Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of colonial-era Massachusetts Bay Colony. While never formally affiliated with any denomination, Harvard trained Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston elite. Following the American Civil War, under Harvard president Charles William Eliot's long tenure from 1869 to 1909, Harvard developed multiple professional schools, which transfo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Class II MHC
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, macrophages, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses. Antigens presented by MHC class II molecules are exogenous, originating from extracellular proteins rather than cytosolic and endogenous sources like those presented by MHC class I. The loading of a MHC class II molecule occurs by phagocytosis. Extracellular proteins are endocytosed into a phagosome, which subsequently fuses with a lysosome to create a phagolysosome. Within the phagolysosome, lysosomal enzymes degrade the proteins into peptide fragments. These fragments are then loaded into the peptide-binding groove of the MHC class II molecule. Once loaded, the MHC class II-peptide complexes are transported to the plasma membrane via vesicular transport, where they present t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
