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David Moore (biologist)
David Dudley Moore (born August 21, 1952) is an American molecular biologist known for his work investigating nuclear hormone receptors. He is a Professor and Chair of the Department of Nutritional Sciences & Toxicology at the University of California, Berkeley. He was a founding editor for the Current Protocols series of laboratory manuals in 1987. Moore has been a leading figure in the investigation of nuclear hormone receptors, having initially discovered and described many family members. Some of his most significant discoveries are the constitutive androstane receptor (CAR) in 1994, farnesoid X receptor (FXR) in 1995, and the small heterodimer partner (SHP) in 1996. In 2019 he was elected to the National Academy of Sciences. Early life and education Moore was born in Brookline, Massachusetts in 1952, and was adopted by Clinton and Emily Moore from The Home for Little Wanderers. He was raised in Cincinnati, Ohio and graduated from Madeira High School in 1970. After co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookline, Massachusetts
Brookline () is an affluent town in Norfolk County, Massachusetts, United States, and part of the Greater Boston, Boston metropolitan area. An exclave of Norfolk County, Brookline borders six of Boston's neighborhoods: Brighton, Boston, Brighton, Allston, Fenway–Kenmore, Mission Hill, Boston, Mission Hill, Jamaica Plain, and West Roxbury. The city of Newton, Massachusetts, Newton borders Brookline to the west. It is known for being the birthplace of John F. Kennedy. The land which comprises what is today Brookline was first settled in 1638 as a Hamlet (place), hamlet in Boston, known as Muddy River (as it was settled on the west side of the Muddy River (Massachusetts), river of the same name). It was incorporated as a separate town with the name of Brookline in 1705. In 1873, Brookline had a Boston–Brookline annexation debate of 1873, contentious referendum in which it voted to remain independent from Boston. The later annexations of Brighton, Boston, Brighton and West Roxbur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edwin B
The name Edwin means "wealth-friend". It comes from (wealth, good fortune) and (friend). Thus the Old English form is Ēadwine, a name widely attested in early medieval England. Edwina is the feminine form of the name. Notable people and characters with the name include: Historical figures * Edwin of Northumbria (died 632 or 633), King of Northumbria and Christian saint * Edwin (son of Edward the Elder) (died 933) * Eadwine of Sussex (died 982), Ealdorman of Sussex * Eadwine of Abingdon (died 990), Abbot of Abingdon * Edwin, Earl of Mercia (died 1071), brother-in-law of Harold Godwinson (Harold II) * Edwin Sandys (bishop) (1519–1588), Archbishop of York Modern era * E. W. Abeygunasekera, Sri Lankan Sinhala politician * Edwin Abbott Abbott (1838–1926), English schoolmaster, theologian, and Anglican priest * Edwin Ariyadasa (1922–2021), Sri Lankan Sinhala journalist * Edwin Arrieta Arteaga (died 2023), Colombian murder victim * Edwin Austin Abbey (1852–191 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lambda Phage
Lambda phage (coliphage λ, scientific name ''Lambdavirus lambda'') is a bacterial virus, or bacteriophage, that infects the bacterial species ''Escherichia coli'' (''E. coli''). It was discovered by Esther Lederberg in 1950. The wild type of this virus has a Temperate (virology), temperate life cycle that allows it to either reside within the genome of its host through lysogeny or enter into a lytic phase, during which it kills and lyses the cell to produce offspring. Lambda strains, mutated at specific sites, are unable to lysogenize cells; instead, they grow and enter the lytic cycle after superinfecting an already lysogenized cell. The phage particle consists of a head (also known as a capsid), a tail, and tail fibers (see image of virus below). The head contains the phage's double-strand linear DNA genome. During infections, the phage particle recognizes and binds to its host, ''E. coli'', causing DNA in the head of the phage to be ejected through the tail into the cytopla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Origin Of Replication
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. Material was copied from this source, which is available under Creative Commons Attribution 4.0 International License This can either involve the DNA replication, replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA virus, DNA or RNA virus, RNA in viruses, such as double-stranded RNA viruses. Synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Providence, Rhode Island
Providence () is the List of capitals in the United States, capital and List of municipalities in Rhode Island, most populous city of the U.S. state of Rhode Island. The county seat of Providence County, Rhode Island, Providence County, it is one of the oldest cities in New England, founded in 1636 by Roger Williams, a Reformed Baptist theologian and religious exile from the Massachusetts Bay Colony. He named the area in honor of "God's merciful Providence" which he believed was responsible for revealing such a haven for him and his followers. The city developed as a busy port, as it is situated at the mouth of the Providence River at the head of Narragansett Bay. Providence was one of the first cities in the country to industrialize and became noted for its textile manufacturing and subsequent machine tool, jewelry, and silverware industries. Today, the city of Providence is home to eight hospitals and List of colleges and universities in Rhode Island#Institutions, eight instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madeira High School
Madeira High School is a public high school in Madeira, Ohio, a bedroom community near Cincinnati, Ohio. Madeira High School is the only high school in the Madeira City Schools District. Academics MHS is known for academic excellence, which has been recognized by '' U.S. News & World Report''; in 2015, the publishing company ranked MHS 13th in the State of Ohio and 282nd in the nation. With a 75 percent student body participation in Advanced Placement Exams, MHS's students have an overall AP Exam pass rate of 81 percent. Student life Madeira's Latin Club, the Madeira Junior Classical League, functions as a local chapter of both the Ohio Junior Classical League (OJCL) and the National Junior Classical League (NJCL). In 2010, Madeira placed second in the Overall Club Sweepstakes at OJCL State Convention and third place in both the 2012 and 2013 State Conventions. Other clubs and activities active at MHS are Art Club, Academic Team, Chess Club, Madeira Marching Mustangs, Madeir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cincinnati
Cincinnati ( ; colloquially nicknamed Cincy) is a city in Hamilton County, Ohio, United States, and its county seat. Settled in 1788, the city is located on the northern side of the confluence of the Licking River (Kentucky), Licking and Ohio River, Ohio rivers, the latter of which marks the state line with Kentucky. It is the List of cities in Ohio, third-most populous city in Ohio and List of united states cities by population, 66th-most populous in the U.S., with a population of 309,317 at the 2020 census. The city is the economic and cultural hub of the Cincinnati metropolitan area, Ohio's most populous metro area and the Metropolitan statistical area, nation's 30th-largest, with over 2.3 million residents. Throughout much of the 19th century, Cincinnati was among the Largest cities in the United States by population by decade, top 10 U.S. cities by population. The city developed as a port, river town for cargo shipping by steamboats, located at the crossroads of the Nor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Home For Little Wanderers
The Home for Little Wanderers is a private non-profit child and family service agency in Boston, Massachusetts Massachusetts ( ; ), officially the Commonwealth of Massachusetts, is a U.S. state, state in the New England region of the Northeastern United States. It borders the Atlantic Ocean and the Gulf of Maine to its east, Connecticut and Rhode .... Founded as an orphanage in 1799, it is the oldest agency of its kind in the United States. Today, the home plays a role in delivering services to thousands of children and families each year through a system of residential, community-based and prevention programs, direct care services and advocacy. The Home's services include early intervention and prevention, foster care and adoption, clinical services, residential care, special education, and home-based family support. See also * Boston Female Asylum, precursor to the Home References External links The Home for Little Wanderers website* * Organizations esta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Current Protocols
''Current Protocols'' is a series of laboratory manuals for life scientists. The first title, ''Current Protocols in Molecular Biology'', was established in 1987 by the founding editors Frederick M. Ausubel, Roger Brent, Robert Kingston, David Moore, Jon Seidman, Kevin Struhl, and John A. Smith of the Massachusetts General Hospital Department of Molecular Biology and the Harvard Medical School Departments of Genetics and Biological Chemistry, and Sarah Greene of Greene Publishing AssociatesAusubel, F. M., Brent, R., Kingston, R., Moore, D. D., Seiman, J., Smith, J. A., and Struhl, K. (1987-2016). ''Current Protocols in Molecular Biology''. New York, NY, John Wiley & Sons, . The Current Protocols series entered into a partnership with Wiley-Interscience, John Wiley and Sons, was acquired by Wiley in 1995, and continued to introduce additional titles. Scientists contribute methods that are peer-reviewed Peer review is the evaluation of work by one or more people with similar co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For The Advancement Of Science
The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education, scientific education and science outreach for the betterment of all humanity. AAAS was the first permanent organization established to promote science and engineering nationally and to represent the interests of American researchers from across all scientific fields. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal ''Science (journal), Science''. History Creation The American Association for the Advancement of Science was created on September 20, 1848, at the Academy of Natural Sciences in Philadelphia, Pennsylvania. It was a reformation of the Association of American Geologists and Naturalists with the broaden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adolf Windaus
Adolf Otto Reinhold Windaus (; 25 December 1876 – 9 June 1959) was a German chemist who won a Nobel Prize in Chemistry in 1928 for his work on sterols and their relation to vitamins. He was the doctoral advisor of Adolf Butenandt who also won a Nobel Prize in Chemistry in 1939. Biography He was born in Berlin, Germany on 25 December 1876 to a family who owned a drapery business. He attended a prestigious French grammar school, where he focused primarily on literature. Windaus began studying medicine at the University of Berlin in about 1895 then proceeded to study chemistry at the University of Freiburg. He married Elizabeth Resau in 1915 and they had three children together, Günter, Gustav, and Margarete. After earning his PhD in medicine, Windaus became the head of the chemical institute at the University of Göttingen from 1915 to 1944. Throughout his life, Windaus won many awards including the Goethe Medal, the Pasteur Medal, and the Nobel Prize for Chemistry. In addi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
