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Danny Welch
Danny Ray Welch is an American cancer biologist and founding director of the University of Kansas Medical Center's Department of Cancer Biology. Welch is also a professor at the University of Kansas School of Medicine and director of the National Foundation for Cancer Research (NFCR) Center for Metastasis Research at KU. His research is in the area of metastasis suppressor genes and the biology of metastasis. He is known for his discovery of a number of metastasis suppressor genes. By definition, these genes suppress metastasis without suppressing growth of the primary tumor. He is also well known for his work in defining the characters of cancer metastasis, and for his mentoring. In 1996, Welch's lab in Hershey, Pennsylvania, isolated a cDNA from a cancer cell that was not able to undergo metastasis after the human chromosome 6 was added to the cell. This gene was named ''KISS1'' because of the location of where it was discovered (Hershey, Pennsylvania, home of Hershey's Kisses) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Kansas School Of Medicine
The University of Kansas School of Medicine is a public medical school located on the University of Kansas Medical Center campuses in Kansas City, Kansas, and also Salina, Kansas, and Wichita, Kansas. The Kansas City campus is co-located with the independent University of Kansas Health System, and they are commonly known collectively as KU Med. History Medical instruction in the University of Kansas School of Medicine began in the 1880s with instruction in medical topics in the undergraduate school, influenced principally by chemistry professor Edgar Bailey. Medical degrees were not awarded. The idea was more fully developed when professor Samuel Wendell Williston came to Kansas from Yale in 1890 and proposed that a specific two-year course of study for medicine should be implemented at KU. In 1899, Williston was named the first dean of this two-year program at KU. The official establishment of the school came in 1905, when the KU Board of Regents authorized the creation of a f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Foundation For Cancer Research
National Foundation for Cancer Research (NFCR) is an American nonprofit organization founded in 1973. It provides funds to cancer scientists and researchers, with the ultimate goal of a cure for cancer. Awards The Szent-Györgyi Prize for Progress in Cancer Research, established by the NFCR and named in honor of Albert Szent-Györgyi Albert Imre Szent-Györgyi de Nagyrápolt ( hu, nagyrápolti Szent-Györgyi Albert Imre; September 16, 1893 – October 22, 1986) was a Hungarian biochemist who won the Nobel Prize in Physiology or Medicine in 1937. He is credited with fi ..., Nobel Laureate and co-founder of NFCR, has been awarded annually since 2006 to outstanding researchers whose scientific achievements have expanded the understanding of cancer and whose vision has moved cancer research in new directions. The Szent-Györgyi Prize honors researchers whose discoveries have made possible new approaches to preventing, diagnosing and/or treating cancer. References Exter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis. Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, after which they a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genes
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Alabama At Birmingham
The University of Alabama at Birmingham (UAB) is a public research university in Birmingham, Alabama. Developed from an academic extension center established in 1936, the institution became a four-year campus in 1966 and a fully autonomous university in the University of Alabama System in 1969. UAB offers 140 programs of study in 12 academic divisions leading to bachelor's, master's, doctoral, and professional degrees in the social and behavioral sciences, the liberal arts, business, education, engineering, and health-related fields such as medicine, dentistry, optometry, nursing, and public health. In the fall of 2019, 22,080 students from more than 110 countries were enrolled. The UAB Health System, one of the largest academic medical centers in the United States, is affiliated with the university. UAB Hospital sponsors residency programs in medical specialties, including internal medicine, neurology, physical medicine and rehabilitation, surgery, radiology, and an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metastasis Suppressor Gene
A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer. Metastasis is one of the most lethal cancer processes. This process is responsible for about ninety percent of human cancer deaths. Proteins that act to slow or prevent metastases are different from those that act to suppress tumor growth. Genes for about a dozen such proteins are known in humans and other animals. Background The treatment of cancer usually aims to destroy and/or stop the growth of the primary tumor. Major improvements in the methods of surgery, radiation and chemotherapy have taken place, but corresponding improvements in patient survival have not always followed. Treatments that focus on the primary cancer typically do not address metastasis. Metastasis suppressors act by different mechanisms than tumor suppressors and do not affect primary tumors. Tumor suppressors, however, also inhibit metastasis, since meta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single-stranded RNA (e.g., messenger RNA (mRNA) or microRNA (miRNA)) template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA is often used to express a specific protein in a cell that does not normally express that protein (i.e., heterologous expression), or to sequence or quantify mRNA molecules using DNA based methods (qPCR, RNA-seq). cDNA that codes for a specific protein can be transferred to a recipient cell for expression, often bacterial or yeast expression systems. cDNA is also generated to analyze transcriptomic profiles in bulk tissue, single cells, or single nuclei in assays such as microarrays, qPCR, and RNA-seq. cDNA is also produced naturally by retroviruses (such as HIV-1, HIV-2, simian immunodeficiency virus, etc.) and then integrated into the host's genome, where it creates a provirus. The term ''cDNA'' is also used, typically in a bioinformatics context, to refer to an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 6
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation. Genes The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins among other functions. Number of genes In 2003, the entirety of chromosome 6 was manually annotated for proteins, resulting in the identification of 1,557 genes, and 633 pseudogenes. The following are some of the newer gene count estimates. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kiss1
Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteins encoded by the ''KISS1'' gene in humans. Kisspeptins are ligands of the G-protein coupled receptor, GPR54. ''Kiss1'' was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research. Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitary triggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and humans. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas. History In 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hershey's Kisses
Hershey's Kisses is a brand of chocolate first produced by the Hershey Company in 1907. The bite-sized pieces of chocolate have a distinctive conical shape, sometimes described as flat-bottomed teardrops. Hershey's Kisses chocolates are wrapped in squares of lightweight aluminum foil. A narrow strip of paper (called a plume) sticks out from the top of each Hershey's Kiss wrapper. Originally designed as a flag for the "Hershey's" brand, the printed paper plumes were added to the Kisses product wrapper in 1921 in order to distinguish the Hershey's Kiss from its competitors who offered similar products. History When first manufactured in 1907, Hershey's Kisses were wrapped by hand. In 1921, a machine was used so the Kisses would be wrapped automatically. This machinery also added the paper plume or paper strip flag to the aluminum foil wrapper to identify Hershey's Kisses, replacing the original small square of printed tissue that was inside the foil wrapper. In 1924, Milton S. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer And Metastasis Reviews
''Cancer and Metastasis Reviews'' is a quarterly peer-reviewed medical review journal covering oncology and the development of new cancer treatments. It was established in 1982 and is published by Springer Science+Business Media. The editors-in-chief are Kenneth V. Honn ( Wayne State University School of Medicine) and Avraham Raz ( Barbara Ann Karmanos Cancer Institute). According to the '' Journal Citation Reports'', the journal has a 2020 impact factor of 9.264. References External links * Academic journals established in 1982 Quarterly journals Oncology journals English-language journals Springer Science+Business Media academic journals Review journals {{oncology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Kansas Faculty
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic Church monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word ''universitas'' (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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