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DSPP
Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth. It is produced by cells (odontoblasts) inside the teeth (dental pulp), and in smaller quantities by bone tissues (osteoblasts and osteocytes). It is required for normal hardening (mineralisation) of teeth. During teeth development, it is broken down into three proteins such as dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). These proteins become the major non-collagenous components of teeth. Their distribution in the collagen matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including type III dentinogenesis imperfecta Dentinogenesis imperfecta (DI) is a genetic disorder of Human tooth development, tooth development. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dentinogenesis Imperfecta
Dentinogenesis imperfecta (DI) is a genetic disorder of Human tooth development, tooth development. It is inherited in an autosomal dominant pattern, as a result of mutations on chromosome 4q21, in the dentine sialophosphoprotein gene (DSPP). It is one of the most frequently occurring autosomal dominant features in humans. Dentinogenesis imperfecta affects an estimated 1 in 6,000-8,000 people. People with this condition have abnormal enamel, short and narrow roots, and can lack nerves. This condition can cause teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent, giving teeth an opalescent sheen. Teeth are also less mineralized than normal, making them prone to rapid wear, breakage, and loss. These problems can affect primary (baby) teeth alone, or both baby teeth and permanent (adult) teeth, with the primary teeth usually more severely affected. Although genetic factors are the main contributor for the condition, any environmental or systemic ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Odontoblast
In vertebrates, an odontoblast is a cell of neural crest origin that is part of the outer surface of the dental pulp, and whose biological function is dentinogenesis, which is the formation of dentin, the substance beneath the tooth enamel on the crown and the cementum on the root. Structure Odontoblasts are large columnar cells, whose cell bodies are arranged along the interface between dentin and pulp, from the crown to the cervix to the root apex in a mature tooth. The cell is rich in endoplasmic reticulum and Golgi complex, especially during primary dentin formation, which allows it to have a high secretory capacity; it first forms the collagenous matrix to form predentin, then mineral levels to form the mature dentin. Odontoblasts form approximately 4 μm of predentin daily during tooth development.Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 170 During secretion after differentiation from the outer cells of the dental papilla, it is noted that it is polarized s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen
Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in cartilage, bones, tendons, ligaments, and skin. Vitamin C is vital for collagen synthesis. Depending on the degree of biomineralization, mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the Gut (anatomy), gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. The fibroblast is the most common cell creating collagen in animals. Gelatin, which is used in food and industry, is collagen t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University College Of Dental Medicine
The Columbia University College of Dental Medicine, often abbreviated CDM, is one of the 21 graduate and professional schools of Columbia University. It is located at 630 West 168th Street in Manhattan, New York City. According to American Dental Education Association, CDM is one of the most selective dental schools in the United States based on average DAT score, GPA, and acceptance rate. In 2017, 1,657 people applied for 84 positions in its entering class. The median undergraduate GPA and average DAT score for successful applicants in 2020 were 3.62 and 22.8, respectively. History The College of Dental Medicine traces its origin to 1852, as the New York College of Dentistry, later the New York College of Dental and Oral Surgery. In 1916, Columbia University, recognizing dentistry as an integral part of the health sciences, established its own school of dental education and absorbed both the New York Post-graduate School of Dentistry and the New York School of Dental Hygiene, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dentin Phosphoprotein
Dentin phosphoprotein, or phosphophoryn, is one of three proteins formed from dentin sialophosphoprotein and is important in the regulation of mineralization of dentin, one of the main constituent materials of teeth (see dentinogenesis). Phosphophoryn is the most acidic protein ever discovered and has an isoelectric point of 1. This extreme acidity is achieved by its amino acid sequence. Many portions of its chain are repeating (aspartic acid-serine-serine) sequences. In protein chemistry, net acidity equates to negative charge. Being highly negative, dentin phosphoprotein is able to attract large amounts of calcium. ''In vitro'' studies also indicate phosphophoryn can initiate hydroxyapatite Hydroxyapatite (International Mineralogical Association, IMA name: hydroxylapatite) (Hap, HAp, or HA) is a naturally occurring mineral form of calcium apatite with the Chemical formula, formula , often written to denote that the Crystal struc ... formation.Nanci, Antonio. Ten Cate's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teeth
A tooth (: teeth) is a hard, calcified structure found in the jaws (or mouths) of many vertebrates and used to break down food. Some animals, particularly carnivores and omnivores, also use teeth to help with capturing or wounding prey, tearing food, for defensive purposes, to intimidate other animals often including their own, or to carry prey or their young. The roots of teeth are covered by gums. Teeth are not made of bone, but rather of multiple tissues of varying density and hardness that originate from the outermost embryonic germ layer, the ectoderm. The general structure of teeth is similar across the vertebrates, although there is considerable variation in their form and position. The teeth of mammals have deep roots, and this pattern is also found in some fish, and in crocodilians. In most teleost fish, however, the teeth are attached to the outer surface of the bone, while in lizards they are attached to the inner surface of the jaw by one side. In cartilaginous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Matrix Proteins
In biology, the extracellular matrix (ECM), also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. Each type of connective tissu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
